کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998288 | 1115618 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective cortical VGLUT1 increase as a marker for antidepressant activity
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کلمات کلیدی
mood disorders - اختلال خلقیTacrine - تاکرینvesicular glutamate transporter - حمل و نقل گلوتامات vesicularAntidepressants - داروهای ضد افسردگیAntipsychotics - داروهای ضد روانپریشیdiazepam - دیازپامCortex - قشرExpression regulation - مقررات بیانMemantine - ممانتین Haloperidol - هالوپریدولHippocampus - هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selective cortical VGLUT1 increase as a marker for antidepressant activity Selective cortical VGLUT1 increase as a marker for antidepressant activity](/preview/png/8998288.png)
چکیده انگلیسی
The two recently characterized vesicular glutamate transporters (VGLUT) presynaptically mark and differentiate two distinct excitatory neuronal populations and thus define a cortical and a subcortical glutamatergic system (VGLUT1 and VGLUT2 positive, respectively). These two systems might be differentially implicated in brain neuropathology. Still, little is known on the modalities of VGLUT1 and VGLUT2 regulations in response to pharmacological or physiological stimuli. Given the importance of cortical neuronal activity in psychosis we investigated VGLUT1 mRNA and protein expression in response to chronic treatment with commonly prescribed psychotropic medications. We show that agents with antidepressant activity, namely the antidepressants fluoxetine and desipramine, the atypical antipsychotic clozapine, and the mood stabilizer lithium increased VGLUT1 mRNA expression in neurons of the cerebral cortex and the hippocampus and in concert enhanced VGLUT1 protein expression in their projection fields. In contrast the typical antipsychotic haloperidol, the cognitive enhancers memantine and tacrine, and the anxiolytic diazepam were without effect. We suggest that VGLUT1 could be a useful marker for antidepressant activity. Furthermore, adaptive changes in VGLUT1 positive neurons could constitute a common functional endpoint for structurally unrelated antidepressants, representing promising antidepressant targets in tracking specificity, mechanism, and onset at action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 49, Issue 6, November 2005, Pages 890-900
Journal: Neuropharmacology - Volume 49, Issue 6, November 2005, Pages 890-900
نویسندگان
Larissa Moutsimilli, Severine Farley, Sylvie Dumas, Salah El Mestikawy, Bruno Giros, Eleni T. Tzavara,