
Design of more potent squalene synthase inhibitors with multiple activities
Keywords: کلسترول تام، کلسترول کلی، کلسترول توتال; SQS, squalene synthase; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; FPP, farnesyl pyrophosphate; BSA, bovine serum albumin; NADPH, nicotinamide adenine dinucleotide phosphate; IC50, inhibitory concentration (for 50% of the reaction); TC, total cholesterol; L