Mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced cardiovascular toxicity: An overview
Keywords: Aryl hydrocarbon receptor; Cardiovascular dysfunction; Dioxin; TCDD;
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Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD
Keywords: Sertoli cell; TCDD; miRNA; RNAseq; Infertility;
Identification of candidate biomarkers of the exposure to PCBs in contaminated cattle: A gene expression- and proteomic-based approach
Keywords: ACN; Acetonitrile; AhR; Aryl hydrocarbon receptor; APO; Apolipoprotein; CNRQ; Calibrated normalized relative quantity; DL; Dioxin-like; ESI-Q; Electrospray ionization quadrupole; GPX; Glutathione peroxidase; HP; Haptoglobin; IL-2; Interleukin 2; LIT; Line
Morbidity in New Zealand pesticide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Keywords: Dioxin; TCDD; Diabetes; Occupation; Health;
Characterization of AHR1 and its functional activity in Atlantic sturgeon and shortnose sturgeon
Keywords: Aryl hydrocarbon receptor 1; Endangered sturgeon species; TCDD; Coplanar PCBs; Gene expression; Reporter gene assays;
Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+in vivo
Keywords: Aryl hydrocarbon receptor; CYP1A1; Cadmium; TCDD; Co-exposure; Zebrafish;
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive
Keywords: AA-EQS; average annual environmental quality standard; ACR; acute-to-chronic ratio; AhR; arylhydrocarbon receptor; AR; androgen receptor; AWTP; advanced water treatment plant; BEQ; bioanalytical equivalent concentration; DWTP; drinking water treatment pla
From TCDD-mediated toxicity to searches of physiologic AHR functions
Keywords: AHR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; PXR; pregnane-X-receptor; CYP; cytochrome P450; IDO1; indoleamine-2,3-dioxygenase; UDP; UDP-glucuronosyltransferase; FICZ; 6-formylindolo[3,2-b]carbazole; ICZ; indolo[3,2-b]carbazole;
Influence of Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) on the In Vitro Characteristics of Equine Gametes
Keywords: Equine; Oocytes; IVM; TCDD; Dioxin; Spermatozoa;
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin promotes inflammation in mouse testes: The critical role of Klotho in Sertoli cells
Keywords: TCDD; Inflammation; Male infertility; Klotho;
Catalytic oxidation of PCDD/F on a V2O5-WO3/TiO2 catalyst: Effect of chlorinated benzenes and chlorinated phenols
Keywords: PCDD/F; Polychlorinated dibenzo-p-dioxins and dibenzofurans; PCDD; Polychlorinated dibenzo-p-dioxins; PCDF; Polychlorinated dibenzofurans; TCDD; Tetra-chlorinated dibenzo-p-dioxins; TCDF; Tetra-chlorinated dibenzofurans; PeCDF; Penta-chlorinated dibenzofu
Exacerbated Immune Complex-Mediated Vascular Injury in Mice with Heterozygous Deficiency of Aryl Hydrocarbon Receptor through Upregulation of Fcγ Receptor III Expression on Macrophages
Keywords: AhR; Aryl hydrocarbon receptor; CXCL1; CXC chemokine ligand 1; DC; dendritic cell; FcγR; Fcγ receptor; FICZ; 6-formylindolo [3,2-b] carbazole; IC; immune complex; PNC; polyarteritis nodosa cutis; RA; rheumatoid arthritis; TCDD; 2,3,7,8-tetrachlorodibenz
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
Keywords: AhR; aryl hydrocarbon receptor; ARNT; ah receptor nuclear translocator protein; ATP; adenosine triphosphate; ASC; apoptosis-associated speck-like protein containing CARD; BMDM; bone marrow-derived macrophage; BSA; bovine serum albumin; Caspase-1; cysteiny
Impairment of ovaries by 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD) exposure in utero associated with BMP15 and GDF9 in the female offspring rat
Keywords: TCDD; Follicular development; GDF9; BMP15; Epigenetics;
In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators
Keywords: AH-receptor; Selective modulators; IMA-06201; IMA-06504; TCDD; Binding modelling;
Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner
Keywords: Ab; antibody; AhR; aryl hydrocarbon receptor; APC; antigen-presenting cell; ARNT; AhR nuclear translocator; BaP; benzo(a)pyrene; BMDCs; bone-marrow derived dendritic cells; BMMs; bone-marrow derived macrophages; CD; cluster of differentiation; CYP 450; cy
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the proteome of porcine granulosa cells
Keywords: TCDD; Proteome; Granulosa cells; Pig;
Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition
Keywords: Major depressive disorder; Oxidative and nitrosative stress; Kynurenine; Aryl hydrocarbon; Immune-inflammation; Mitochondria; Pathophysiology; Melatonin; Treatment; Classification; Cognition; 3-OH-ANA; 3-hydroxyanthranillic acid; 3-OH-Kyn; 3-hydroxykynure
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
TCDD-induced mitochondrial superoxide production does not lead to mitochondrial degeneration or genomic instability in human SH-SY5Y neuroblastoma cells
Keywords: Micronuclei; ROS production; Mitochondria; TCDD; Genomic instability;
DFT study of the adsorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin on pristine and Ni-doped boron nitride nanotubes
Keywords: Boron nitride nanotubes; Ni doping; TCDD; Adsorption; DFT;
Effects of polychlorinated biphenyls on metamorphosis of a marine fish Japanese flounder (Paralichthys olivaceus) in relation to thyroid disruption
Keywords: TDCs; thyroid-disrupting chemicals; PAHs; polycyclic aromatic hydrocarbons; PCBs; polychlorinated biphenyls; THs; thyroid hormones; TTR; transthyretin; TU; thiourea; T4; thyroxine; TCDD; tetrachlorodibenzo-p-dioxin; PCB 126; 3, 3â², 4, 4â², 5-pentachlor
2,3,7,8-tetrachlorodibenzo-p-dioxin and the viral infection
Keywords: TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; AhR; Aryl hydrocarbon Receptor; 2; 4,5-T, 2,4,5-trichlorophenoxyacetic acid; NK cells; natural killer cells; CB3; human coxsackievirus B3; HIV-1; Human immunodeficiency virus-1; CMV; cytomegalovirus; HSV-II; herp
Aryl hydrocarbon receptor activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs human B lymphopoiesis
Keywords: HSC; hematopoietic stem cell; AHR; aryl hydrocarbon receptor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; HSPC; hematopoietic stem and progenitor cell; CLP; common lymphoid progenitor; IL7R; interleukin-7 receptor; IL7Rα; interleukin-7 receptor α chain;
Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure
Keywords: TCDD; Long-term exposure; Neurotoxicity; Microarray; Neuroinflammation;
AHR toxicity and signaling: Role of TIPARP and ADP-ribosylation
Keywords: Aryl hydrocarbon receptor; 2,3,7,8-Tretrachlorodibenzo-p-dioxin; ADP-ribosylation; TCDD-inducible poly-ADP-ribose polymerase; AHR; aryl hydrocarbon receptor; AHRE; AHR response element; ARH; ADP-ribosyl hydrolases; ARNT; AHR nuclear translocator; ARTD; AD
Adsorption behavior of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on pristine and doped black phosphorene: A DFT study
Keywords: Phosphorene; Doping; Density functional theory; TCDD;
Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis
Keywords: UC; Ulcerative colitis; CAC; Colitis-associated colon cancer; Ahr; Aryl hydrocarbon receptor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; DIM; 3,3â²-diindolylmethane; miRNA; MicroRNA; AChE; Acetylcholinesterase; Ach; Acetylcholine; AOM; Azoxymethane; DSS;
Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet
Keywords: TCDD; Chronic exposure; Obesogen;
Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; DRE; dioxin responsive element; DMEM; Dulbecco modified Eagle medium; DMSO; dimethylsulfoxide; EMSA; electrophoretic mobility shift assay; EROD; 7-
DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor
Keywords: Tcdd; Apoptosis; DNA damage; Cytochrome P450; Aryl hydrocarbon receptor; Clotrimazole;
Toxicological characterisation of two novel selective aryl hydrocarbon receptor modulators in Sprague-Dawley rats
Keywords: AH-receptor; Selective modulators; Ima-08401; Ima-07101; TCDD; Toxicity;
Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner
Keywords: AHR; ICZ; Indole-3-carbinol; Broccoli; Intestinal homeostasis; Ah receptor; Glucobrasscin (PubChem CID: 6602378); Indole-3-carbinol (PubChem CID: 3712); 3,3â²-Diindolylmethane (PubChem CID: 3071); Indolo[3,2-b]carbazole (PubChem CID: 114764); AHR; aryl h
Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism
Keywords: AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; CYP; cytochrome P450; EMT; epithelial-to-mesenchymal transition; Cx43; connexin 43; GJIC; gap junction intercellular communication; HMGCoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; NHE1; Na
Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals
Keywords: AA; arachidonic acid; AHH; aryl hydrocarbon hydoxylase; AHR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor translocator; B6; C57BL/6J mice; bHLH; basic-helix/loop/helix domain in proteins; Chr; chromosome; CNS; central nervous system; CYP; cy
AHR in the skin: From the mediator of chloracne to a therapeutic panacea?
Keywords: Arylhydrocarbon receptor; Skin; Inflammation; Dietary ligands; Air pollution; AHR; aryl hydrocarbon receptor; AHRR; AHR-repressor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; IDO; indoleamin-2,3,-dioxygenase; NFκB; nuclear factor κB; DC; dendritic cell;
And now for something completely different: Diversity in ligand-dependent activation of Ah receptor responses
Keywords: Ah receptor; AhR; TCDD; Ligand binding; Ligand specificity; Toxicity;
ITE Suppresses Angiogenic Responses in Human Artery and Vein Endothelial Cells: Differential Roles of AhR
Keywords: AhR; Aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; CYP1A1; cytochrome P450 family 1 member A1; CYP1B1; cytochrome P450 family 1 member B1; BM; basal RPMI 1640 media; CGM; complete growth medium; FBS; fetal bovine serum; FGF2; fibroblast growth factor
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
Adsorption of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on pristine, defected and Al-doped carbon nanotube: A dispersion corrected DFT study
Keywords: Al-doped CNT; TCDD; DFT-D; Adsorption; Hazardous materials;
Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells
Keywords: ADH; Alcohol dehydrogenase; AHR; Aryl hydrocarbon receptor; ALD; Alcohol liver disease; ARNT; AHR nuclear translocator; CAR; Constitutive androstane receptor; CYP; Cytochrome P450; ER; Estrogen receptor; OCP; Organochlorine pesticide; POP; Persistent orga
Cell and region specificity of Aryl hydrocarbon Receptor (AhR) system in the testis and the epididymis
Keywords: Aryl hydrocarbon receptor; Testis; Epididymis; TCDD;
Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models
Keywords: TCDD; Transgenerational; Endometriosis; Adenomyosis; Preterm birth; Epigenetics;
In utero exposure to carcinogens: Epigenetics, developmental disruption and consequences in later life
Keywords: 5-mc; 5-methylcytosine; AhR; aryl hydrocarbon receptor; AKT; protein kinase B; BPA; bisphenol A; CNS; central nervous system; CS; cigarette smoke; DBP; dibenzo(α1) pyrene; DES; diethylstilboestrol; DNMT; N-methyltransferase; E2; 17-β-oestradiol; ED; end
Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays
Keywords: Bortezomib; Carfilzomib; Firefly luciferase; Inhibition; Ixazomib; Reporter gene assay; PXR; pregnane-X-receptor; RT-qPCR; reverse transcription-quantitative polymerase chain reaction; DMSO; dimethyl sulfoxide; PBS; phosphate-buffered saline; BSA; bov
Research paperPrenatal low dosage dioxin (TCDD) exposure impairs cochlear function resulting in auditory neuropathy
Keywords: TCDD; Dioxin; Cochlea; DPOAE; ABR; Mouse; Auditory neuropathy; High affinity aryl hydrocarbon receptor; Ah b1 allele;
Aryl hydrocarbon receptor negatively regulates lipid synthesis and involves in cell differentiation of SZ95 sebocytes in vitro
Keywords: Aryl hydrocarbon receptor; CYP1A1; TCDD; Sebaceous gland; SZ95 sebocytes; Differentiation;
Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish
Keywords: Cardiovascular toxicity; Prostacyclin; TCDD; Thromboxane; Zebrafish
MicroRNAs: New regulators of IL-22
Keywords: IL-22; interleukin-22; Th22; T helper 22 cell; Th1; T helper 1 cell; Th17; T helper 17 cell; NK22; natural killer 22; NKT; natural killer T cell; ILCs; innate lymphoid cells; RORγt; retinoid orphan receptor γt; STAT3; signal transducer and activator of