کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8920281 | 1643351 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AHR in the skin: From the mediator of chloracne to a therapeutic panacea?
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کلمات کلیدی
PHAHAHRpolyhalogenated aromatic hydrocarbonstype 17 helper T cellPAHAHRR6-formylindolo[3,2-b]carbazolei3CFICZTh17TregTCDDIDO2,3,7,8-Tetrachlorodibenzo-p-dioxin - 2،3،7،8-تترا کلریدیبنزوپتوفان دیوکسین3,3′-diindolylmethane - 3،3'-diindolylmethaneIndole-3-carbinol - Indole-3-CarbinolNFκB - NFKBAir pollution - آلودگی هواSTAT - آمارDIM - اذعانinflammation - التهاب( توروم) interleukin - اینترلوکینRegulatory T cell - سلول T تنظیم کنندهDendritic cell - سلول دندریتیکnuclear factor κB - فاکتور هسته ای κBSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیPolycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهایSkin - پوستarylhydrocarbon receptor - گیرنده arylhydrocarbonaryl hydrocarbon receptor - گیرنده آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The transcription factor AHR is highly expressed in all skin cells and an increasing body of evidence shows its involvement in immunity of barrier organds. The AHR is activated by many molecules found in the environment, both man-made and natural compounds, e.g., from dietary plants. Also endogenous activators of AHR were identified. We here review beneficial and adverse functions of activated AHR for skin integrity and skin health. We identify open questions, and hypothesize how concurrent inflammatory events can influence the outcome of physiological AHR signaling in the skin. AHR is a highly interesting therapeutic target, but different ligands can result in completely different immune effects. The underlying reasons, such as possible differences in ligand-induced conformational changes, are often unclear or speculative. This remains a challenge for therapeutic use. Also, long-term effects such as epigenetic changes need to come more into focus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Toxicology - Volume 2, February 2017, Pages 79-86
Journal: Current Opinion in Toxicology - Volume 2, February 2017, Pages 79-86
نویسندگان
Katja Merches, Thomas Haarmann-Stemmann, Heike Weighardt, Jean Krutmann, Charlotte Esser,