دانلود مقالات ISI درباره Td50 + ترجمه فارسی

افزایش حساسیت تشنج و سایر علائم سمیت پس از درمان سولفورفان حاد در موش سوری

Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice

Keywords: ARE; antioxidant response element; C.L.; confidence limit; CS50; current strength required to induce seizure response in 50% of mice; DMSO; dimethyl sulfoxide; ED50; median effective dose; ip; intraperitoneally; IS; internal standard; iv; intravenously; L

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

شامل توانایی در طبقه بندی اتحادیه اروپا برای سرطان زایی و سمیت تولید مثل

Incorporating potency into EU classification for carcinogenicity and reproductive toxicity

Keywords: C&L; Classification and Labelling; CLP; Classification and Labelling and Packaging Regulations; CMR; carcinogenicity, mutagenicity and reproductive toxicity; D/RT; developmental/reproductive toxicity; EC; European Community; ECETOC; European Centre for Ec

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

Keywords: CNS; central nervous system; COX; cyclooxygenase; EEG; electroencephalography; ED50; median effective dose; MAM; methylazoxymethanol; MES; maximal electroshock; MRP; multidrug resistance-associated protein; PTZ; pentylenetetrazole; scPTZ; subcutaneous pen

دانلود رایگان متن کامل مقاله ISI 87 صفحه سال انتشار : 2018 سفارش ترجمه

sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain

Keywords: SPD; sec-butylpropylacetamide; VPA; valproic acid; CAPs; compound action potentials; AED; antiepileptic drugs; SNL; spinal nerve ligation; PK; pharmacokinetic; PD; pharmacodynamic; VFF; von-Frey filaments; MC; methyl cellulose; TPE; time to peak effect; A

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels

Keywords: AAA; α-aminoamide; ASD; antiseizure drug; ASP; Anticonvulsant Screening Program; CAD; catecholamine A-differentiated; CNS; central nervous system; ED50; effective dose (50%); FAA; functionalized amino acid; IBCF; isobutyl chloroformate; IC50; concentrati

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)

Keywords: ACR; acute-to-chronic ratios; AF; assessment factor; BCF; bioconcentration factor; BOD5; 5-days biochemical oxygen demand; C&L; classification and labeling; CLP; classification, labeling and packaging; COD; chemical oxygen demand; CSA; chemical safety ass

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Risk assessment scenarios of children's exposure to aflatoxin M1 residues in different milk types from the Greek market

Keywords: AFB1; aflatoxin B1; AFM1; aflatoxin M1; ALARA; as low as reasonably achievable; EDI; estimated daily intake; ELISA; Enzyme-Linked Immunosorbent Assay; HI; hazard index; LOD; limit of detection; MRLs; maximum residues limits; TD50; threshold dose; TDI; tol

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Keywords: ADME; absorption distribution metabolism and excretion; AEDs; antiepileptic drugs; AUC; area under the plasma drug concentration-time curve; BBB; blood-brain barrier; CBZ; carbamazepine; CBZ-E; carbamazepine-10,11-epoxide; Cmax; maximum peak concentra

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

Keywords: AED; antiepileptic drug; ASP; Anticonvulsant Screening Program; B:P; brain-to-plasma; Cbz; carboxybenzyl; DBU; 1,8-diazabicycloundec-7-ene; DIPEA; N,N-diisopropylethylamine; DMTMM; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; ED50;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Improved in silico prediction of carcinogenic potency (TD50) and the risk specific dose (RSD) adjusted Threshold of Toxicological Concern (TTC) for genotoxic chemicals and pharmaceutical impurities

Keywords: TTC; Threshold of toxicological concern; Genotoxic; Mutagenic; Impurities; QSAR; SAR; TD50; Pharmaceuticals; Food contact substances; RSD; Carcinogenicity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances

Keywords: Genotoxic; Impurities; In silico; Carcinogenicity; Threshold of toxicological concern; Pharmaceutical; TD50; Cancer potency;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

ECoG studies of valproate, carbamazepine and halothane in frontal-lobe epilepsy induced by head injury in the rat

Keywords: AED; anti-epileptic drug; VPA; valproaic acid; CBZ; carbamazepine; CSRSs; chronic spontaneous recurrent seizures; CPS; complex partial seizure; TD50; dose producing toxicity in 50% of subjects; Posttraumatic epilepsy; Neocortical epilepsy; Trauma; Screeni

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2010 سفارش ترجمه

Transport of simazine in unsaturated sandy soil and predictions of its leaching under hypothetical field conditions

Keywords: BTC(s); breakthrough curve(s); Cl−; Chloride; Kd; equilibrium linear adsorption coefficient; LEA; local equilibrium assumption; NLEA; non-local equilibrium assumption; TD50; half life; Herbicide transport; Non-equilibrium sorption; Breakthrough curve; H

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

The use of structure-activity relationship analysis in the food contact notification program

Keywords: Structure-activity relationship; Food and drug administration; Threshold of regulation; Food contact substances; Food contact notification; Mutagenicity; TD50; MCASE; OnocoLogic; Structure alerts;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه