Keywords: Breast cancer; Lithocholic acid; Endothelial-mesenchymal transition; OXPHOS; Microbiome; TGR5;
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: AMPK; adenosine 5â²-monophosphate (AMP)-activated protein kinase; ANGPTL4; angiopoietin-like protein 4; AX; arabinoxylan; CAZymes; carbohydrate active enzymes; CBMs; carbohydrate-binding modules; CVD; cerebrobascular disease; ERs; estrogen receptors; IL;
Keywords: Bile-acids; GLP-1; Neurotensin; Insulin; PYY; TGR5;
Keywords: Serotonin; Stress; Irritable Bowel Syndrome; Intestinal Permeability; ANS; autonomic nervous system; ASD; autism spectrum disorder; BBB; blood-brain barrier; BGM; brain-gut-microbiome; CNS; central nervous system; ECC; enterochromaffin cell; EEC; enteroen
Keywords: BA; bile acids; BSH; bile salt hydrolase; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; LCA; litocholic acid; MCA; muricholic acid; CYP7A1; cholesterol 7-αhydroxylase; L.; Lactobacillus; B.; Bifidobacterium; EPS; exopolysaccharide;
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: Nuclear receptor; TGR5; Metabolic syndromes; Fatty liver disease;
Keywords: Genetic variability; Postnatal development; Brown adipocytes; Inguinal white fat; Interscapular brown fat; Reduced ambient temperature; Thermoneutrality; Gut microbiota; Bile acids; AMPK; AMP-activated protein kinase; BA; bile acid; BAP; brown adipocyte p
Keywords: Bile Acids; FXR; TGR5; Meta-Inflammation; apo; apolipoprotein; ASBT; apical sodiumâdependent bile acid transporter; BA; bile acid; BAS; bile acid sequestrant; BAT; brown adipose tissue; BSH; bile salt hydrolase; CA; cholic acid; CCK; cholecystokinin; CD
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: Liver regeneration; Bile acid; FXR; TGR5; FGF15;
Keywords: bile acid sequestrant; type 2 diabetes; glucose homeostasis; FXR; TGR5
Keywords: Bile acids; FXR; TGR5; Obesity; Insulin resistance
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: Bile acids; FXRα; TGR5; Cancer;
Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes
Keywords: TGR5; TGR5 agonist; GPBAR1; GLP1 secretion; Type 2 diabetes; Sitagliptin; DPP-4 inhibitor;
Activation of TGR5 promotes mitochondrial biogenesis in human aortic endothelial cells
Keywords: TGR5; Endothelial cells; Mitochondrial biogenesis; CREB; PGC-1α;
Bile acid receptors in the biliary tree: TGR5 in physiology and disease
Keywords: AC; adenylate cyclase; BS; bile salt; BSEP; bile salt export pump (ABCB11); CA; cholic acid/cholate; cAMP; cyclic AMP; CBDL; common bile duct ligation; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid/chenodeoxycholate; CD95L; CD95 ligand; CFTR; cysti
INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis
Keywords: Acute pancreatitis; TGR5; INT-777; Reactive oxygen species; NLRP3 inflammasome;
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
Keywords: BA; bile acid; CCA; cholangiocarcinoma; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; FXR; farnesoid X receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GPBAR1 (or TGR5); G protein-coupled bile acid receptor 1; MRI; magnetic
Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models
Keywords: ALT; alanine transferases; ALP; alkaline phosphatase; BA; bile acid; bcoA; butyryl-coenzyme-A-CoA transferase; buk; butyrate kinase; B. infantis; Bifidobacterium longum subsp. infantis; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid;
The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway in non-small cell lung cancer
Keywords: TGR5; JAK2/STAT3; NSCLC; Bile acids;
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
Keywords: Farnesoid X receptor; TGR5; Atherosclerosis; Obesity; NAFLD; α-Sma; alpha smooth muscle actin (α-Sma); BA; bile acid; BAT; brown adipose tissue; CEBPα; CCAAT/enhancer-binding protein α; Col1α1; collagen type 1 α1; DIO; diet-induced obesity; FXR; far
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Transhepatic bile acid kinetics in pigs and humans
Keywords: Bile acids; TGR5; Porcine; Postprandial; Portal concentrations; BAs; bile acids; ASBT; apical sodium-dependent bile acid transporter; OST; organic solute transporter; NTCP; taurocholate cotransporting polypeptide; OATP; organic anion transporting polypept
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand
Keywords: CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; LCA; litocholic acid; BAs; bile acids; BARS; bile acid activated receptors; GPBAR1; G protein coupled bile acid receptor; TGR5; Takeda G protein receptor 5; FXR; farnesoid x-receptor; PX
Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice
Keywords: Alzheimer's disease; INT-777; TGR5; Aβ1-42; Neurotoxicity; Cognitive; Neuroinflammation; Apoptosis; Synaptic dysfunction; Memory;
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists
Keywords: TGR5; Imidazole; OGTT; Gall bladder;
Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats
Keywords: Glycyrrhizic acid; GLP-1; TGR5; Triamterene; Sitagliptin;
Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway
Keywords: Bile acids; Gallbladder; Enteroendocrine; Glucagon-like peptide; TGR5; GLP-1; GLP-2;
Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J mice
Keywords: Bile acids; Obesity; Weight loss; Gene expression; Mice; Abcc3; ATP binding cassette subfamily C member 3; Acox2; peroxisomal branched chain acyl-CoA oxidase; Amacr; α-methylacyl-CoA racemase; ANOVA; analysis of variance; BA; bile acids; Bal; bile acid C
Ischemic Preconditioning protects hepatocytes from ischemia-reperfusion injury via TGR5-mediated anti-apoptosis
Keywords: TGR5; Ischemic preconditioning; Ischemia-reperfusion injury; Hepatocellular apoptosis;
Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion
Keywords: GLP-1; GIP; Incretin; Secretagogue; TGR5;
The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells
Keywords: 6E-CDCA; 6-Ethyl-chedeoxycholic acid; ADP; Adenosine diphosphate; AKT or PTB; Protein kinase B; ATP; Adenosine triphosphate; AUC; Area under curve; BSA; Bovine serum albumin; cAMP; Cyclic adenosine monophosphate; CREB; cAMP response element-binding protei
An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease
Keywords: Bile Acids; Farnesoid X Receptor; Metabolic Disease; Ceramides; BSH; bile salt hydrolase; CA; cholic acid; cAMP; cyclic adenosine monophosphate; CDCA; chenodeoxycholic acid; CYP; cytochrome P450s; CYP7A1; CYP with cholesterol 7α-hydroxylase; DCA; deoxych
Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway
Keywords: Obacunone; TGR5; PPARγ; Hyperglycemia; Obesity; Hypertrophy;
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
Keywords: inflammation; macrophages; metabolism; bile acids; TGR5
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists
Keywords: TGR5; Pyrimidine; Malonamide; Agonist; Bioisostere;
4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists
Keywords: TGR5; 4-Benzofuranyloxynicotinamide; Gallbladder toxicity; Caco-2 permeability
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate
Keywords: TGR5; Human adipose tissue; Gene expression; Obesity; Resting metabolic rate;
The solute carrier family 10 (SLC10): Beyond bile acid transport
Keywords: SLC10; Bile acid; ASBT; NTCP; SOAT; TGR5;
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists
Keywords: GPBAR1; TGR5; PYY; GLP-1; Chemical probe
Bile acid receptors in non-alcoholic fatty liver disease
Keywords: FXR; TGR5; Triglyceride; Cholesterol; Inflammation
Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold
Keywords: TGR5; GPCR; Diabetes; 4-Phenyl pyridine
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Keywords: Diagnosis; Epidemiology; Cancer Risk; Mechanisms; ALT; alanine aminotransferase; APOC3; apolipoprotein C3; ARFI; acoustic radiation force impulse elastography; AST; aspartate aminotransferase; ATF6; activating transcription factor-6; AUROC; area under the
Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet
Keywords: FXR; Limonoid; Nomilin; TGR5
Research ArticleImmediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis
Keywords: Hepatectomy; Vasopressin; Portal pressure; Cholestasis; Bile acids; GPBAR1; TGR5; AVP; arginine vasopressin; PH; partial hepatectomy; SON; supraoptic nucleus; PVN; paraventricular nucleus; PVS; portal vein stenosis; BDL; bile duct ligation; PCA; porto-cav
ReviewThe bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
Keywords: Bile acids; Diabetes; Energy homeostasis; FXR; GLP-1; G-protein coupled receptor; Nuclear receptors; TGR5;
Nuclear Receptors as New Perspective for the Management of Liver Diseases
Keywords: BSEP (ABCB11); bile salt export pump; CAR (NR1I3); constitutive androstane receptor; ERα (NR3A1); estrogen receptor alpha; FXR (NR1H4); farnesoid X receptor/bile acid receptor; HSC; hepatic stellate cells; NAFLD; nonalcoholic fatty liver disease; NASH; n