کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572427 1129295 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
چکیده انگلیسی

In the past decade substantial progress has been made in understanding how the insurgence of chronic low-grade inflammation influences the physiology of several metabolic diseases. Tissue-resident immune cells have been identified as central players in these processes, linking inflammation to metabolism. The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and its activation mediates potent anti-inflammatory effects. Herein, we summarize recent advances in TGR5 research, focusing on the downstream effector pathways that are modulated by TGR5 activators, and on its therapeutic potential in inflammatory and metabolic diseases.

TrendsLow-grade chronic inflammation, characterized by elevated proinflammatory gene expression, confers susceptibility to metabolic diseases and promotes metabolic syndrome.Bile acids, initially discovered as lipid solubilizers, are now recognized as signaling molecules with an anti-inflammatory action.TGR5 activation blocks inflammation by reducing macrophage activation, thereby preserving metabolic function.TGR5 agonists have therapeutic potential to treat immunometabolic disorders, including atherosclerosis and diet-induced obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 36, Issue 12, December 2015, Pages 847–857
نویسندگان
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