Keywords: نیمه حداکثر غلظت مهاری; AD; Alzheimer's disease; DA; dopamine; DAergic; dopaminergic; hMAO-A; human monoamine oxidase A; hMAO-B; human monoamine oxidase B; HRP; horseradish peroxidase; IC50; the half maximal inhibitory concentration; i.p.; intraperitoneal; Ki; inhibition const
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Keywords: نیمه حداکثر غلظت مهاری; A; Electrode surface area; aâ; Redness-greenness; Ablank; Absorbance of blank (control); Asample; Absorbance of samples; B; Color intensity; bâ; Blueness-yellowness; BHT; Butylated hydroxytoluene; CRM; Certified reference materials; DPPH; 2,2 diph
Keywords: نیمه حداکثر غلظت مهاری; FBS; fetal bovine serum; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; HEK; human embryonic kidney cells; IC50; the half maximal inhibitory concentration; ROS; reactive oxygen species; U2OS; human bone osteosarcoma epithelial cells; μ
Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells
Keywords: نیمه حداکثر غلظت مهاری; CDX1; caudal type homeobox 1; CDX2; caudal type homeobox 2; GAPDH; glyceraldehydeâ3âphosphate dehydrogenase; miR; MicroRNA; MTT; 3â(4,5âdimethylthiazolâ2âyl)â2,5âdiphenyltetrazolium bromide; HPLC; high-performance liquid chromatography; FB
N-acetylcysteine modified hyaluronic acid-paclitaxel conjugate for efficient oral chemotherapy through mucosal bioadhesion ability
Keywords: نیمه حداکثر غلظت مهاری; HA; hyaluronic acid; PTX; paclitaxel; NAC; N-acetylcysteine; DCC; dicyclohexylcarbodiimide; DMAP; 4-dimethylaminopyridine; DMF; N,N-dimethylformamide; NAC-HA-PTX; NAC modified HA-PTX; CMC; critical micelle concentration; C6; coumarin 6; DS; the degree of
Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma
Keywords: نیمه حداکثر غلظت مهاری; Esophageal squamous cell carcinoma; Targeting c-Myc; JQ1; c-Myc amplification; Patient derived xenograft; ESCC; esophageal squamous cell carcinoma; BET; bromodomain and extra-terminal; IC 50; the half maximal inhibitory concentration; NGS; Next-Generation
The second generation tyrosine kinase inhibitor dasatinib induced eryptosis in human erythrocytes-An in vitro study
Keywords: نیمه حداکثر غلظت مهاری; ALL; acute lymphoblastic leukemia; [Ca2+]i; cytosolic free Ca2+ ion concentration; CML; chronic myelogenous leukemia; DPH; 1,6-diphenyl-1,3,5-hexatriene; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; Hb; hemoglobin; IC50; the half maximal inhib
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo
Keywords: نیمه حداکثر غلظت مهاری; Behavioural experiment; Electrophysiology; Glutamate receptor; Human pathogenic mutation; Ion channel; Pharmacology; AD; Alzheimer's disease; AMPA; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; ANOVA; Analysis of Variance; CAS; Czech Academy o
MicroRNA-223-3p regulates cell chemo-sensitivity by targeting FOXO3 in prostatic cancer
Keywords: نیمه حداکثر غلظت مهاری; PCa; Prostate cancer; miRNAs; MicroRNAs; FOXO; forkhead box; qRT-PCR; Quantitative real-time polymerase chain reaction; SD; standard deviation; IC50; the half maximal inhibitory concentration; MiR-223-3p; Chemo-sensitivity; FOXO3; Prostatic cancer;
Biological applications of Ru(II) polypyridyl complexes
Keywords: نیمه حداکثر غلظت مهاری; FDA; United States Food and Drug Administration; PDT; photodynamic therapy; PS; photosensitizer; ROS; reactive oxygen species; PACT; photodynamic antimicrobial chemotherapy; NKP-1339; sodium salt of indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(I
Traditional medicines used by Q'eqchi' Maya to treat diabetic symptoms and their antiglycation potential
Keywords: نیمه حداکثر غلظت مهاری; AGE; advanced glycation endproduct; IC50; the half maximal inhibitory concentration; SIV; syndromic importance value; T2D; type two diabetes; 4-HBA; 4-Hydroxy Benzoic Acid; Antidiabetic ethnobotany; Tynanathus guatemalensis; Verbascoside; Advanced glycati
Anticancer activity study of A3 adenosine receptor agonists
Keywords: نیمه حداکثر غلظت مهاری; AC; adenylyl cyclase; A3AR; A3 Adenosine receptor; Caco-2; epithelial colorectal carcinoma; CHO; Chinese hamster ovary; Cl-IB-MECA; 2-chloro-N6-(3-iodobenzyl)-adenosine-5â²-N-methyluronamide; DMEM; Dulbecco's modified eagle medium; DMSO; dimethyl sulphox
Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites
Keywords: نیمه حداکثر غلظت مهاری; CYP4A11; Reaction phenotyping; HET0016; Plumbagin; Lauric acid metabolism; HLM; human liver microsomes; CYP; cytochrome P450; 20-HETE; 20-hydroxyeicosatetraenoic acids; LC-MS/MS; liquid chromatography-tandem mass spectrometry; IC50; the half maximal inh
Effects of BPA on global DNA methylation and global histone 3 lysine modifications in SH-SY5Y cells: An epigenetic mechanism linking the regulation of chromatin modifiying genes
Keywords: نیمه حداکثر غلظت مهاری; 5-mC; 5-methylcytosine; 5-hmC; 5-hydroxymethylcytosine; BPA; bisphenol A; EFSA; European Food Safety Authority; H3K9ac; histone H3 lysine 9 acetylation; H3K9me3; histone H3 lysine 9 trimethylation; H3K27me3; histone H3 lysine 27 trimethylation; H3K4me3; h
Facile encapsulation of hydroxycamptothecin nanocrystals into zein-based nanocomplexes for active targeting in drug delivery and cell imaging
Keywords: نیمه حداکثر غلظت مهاری; NPs; nanoparticles; HCPT; hydroxycamptothecin; PFA; folate-conjugated polydopamine; NCs; nanocomplexes; DDSs; drug delivery systems; PDA; polydopamine; DNC; drug nanocrystals; SAS; supercritical anti-solvent; BUDP; built-in ultrasonic dialysis process; FA
New bimetallic dicyanidoargentate(I)-based coordination compounds: Synthesis, characterization, biological activities and DNA-BSA binding affinities
Keywords: نیمه حداکثر غلظت مهاری; Dicyanidoargentat(I); 2,2â²-(ethylenedioxy)bis(ethylamine); Anticancer activity; Antimicrobial activity; Antifugal activity; Apoptosis; Bcl-2; B-cell lymphoma 2; CC1; cell conditioning 1; CK7; Cytokeratin 7; CK20; Cytokeratin 20; CPT; camptothecin; HIER;
Prostaglandin H synthase kinetics in the two-phase aqueous-micellar system
Keywords: نیمه حداکثر غلظت مهاری; PGHS; prostaglandin H synthase; AA; arachidonic acid; COX reaction; cyclooxygenase reaction; POX reaction; peroxidase reaction; KM; Michaelis constant in the Michaelis-Menten equation; Vm; the maximum enzymatic reaction rate in the Michaelis-Menten equati
Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation
Keywords: نیمه حداکثر غلظت مهاری; IC50; the half maximal inhibitory concentration; ACP; acid phosphatase; ALP; alkaline phosphatase; ALT; alanine transaminase syn. alanine aminotransferase syn. serum glutamic: pyruvic transaminase; AST; aspartate aminotransferase syn. aspartate transamina
Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease
Keywords: نیمه حداکثر غلظت مهاری; CVB3; Cosxackievirus B3; CVB3 3Cpro; Cosxackievirus B3 3C protease; FRET; fluorescence resonance energy transfer; l-DOPA; levodopa; Boc; tert-butyloxycarbonyl; TFA; trifluoroacetic acid; DCM; dichloromethane; IC50; the half maximal inhibitory concentratio
Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies
Keywords: نیمه حداکثر غلظت مهاری; ASO; Antisense Oligonucleotide; CNS; Central Nervous System; ECG; Electrocardiography; FOB; Functional Observatory Battery; GLP; Good Laboratory Practice; hERG; Human Ether-a-go-go related gene; ICH; International Conference on Harmonisation; IC50; The ha
The inhibitory activity of atractylenolide Ш, a sesquiterpenoid, on IgE-mediated mast cell activation and passive cutaneous anaphylaxis (PCA)
Keywords: نیمه حداکثر غلظت مهاری; Ag; antigen; Akt; Protein kinase B; AT III; Atractylenolide III; ED50; the half maximal effective dose; FcεRI; Fc Epsilon Receptor 1 alpha; Gab2; Growth factor receptor bound protein 2-associated protein 2; IC50; the half maximal inhibitory concentration
Antihyperglycemic activity with DPP-IV inhibition of alkaloids from seed extract of Castanospermum australe: Investigation by experimental validation and molecular docking
Keywords: نیمه حداکثر غلظت مهاری; CAS; Castanospermum australe seed; PX-407; poloxamer-407; T2DM; Type 2 diabetes mellitus; HbA1c; glycosylated haemoglobin; OGTT; oral glucose tolerance test; KITT; insulin sensitivity index; HOMA-R; homeostasis model assessment of insulin resistance; DPP-
Cone snail milked venom dynamics - A quantitative study of Conus purpurascens
Keywords: نیمه حداکثر غلظت مهاری; Cone snail; Toxins; Conus purpurascens; Envenomation; Conotoxins; Conopeptides; Mass spectrometry; Milked venom; Peptide quantification; Amino acid analysis; Radula harpoon; aq.; aqueous; aq. TFA; Aqueous Trifluroacetic acid; Calc. MH+; Calculated Monoiso