کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8434737 | 1546650 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma
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کلمات کلیدی
PDXC-MYC amplificationTGIJQ1CDXESCCNGSCNVbromodomain and extra-terminal - برومودومین و اضافی ترمینالPatient derived xenograft - بیمار مبتلا به زونا زودرسNext-generation sequencing - تعیین توالی نسل بعدیcopy number variation - تنوع نسخه کپیEMT - تکنسین فوریتهای پزشکیBET - شرطTumor Growth Inhibition - مهار رشد تومورthe half maximal inhibitory concentration - نیمه حداکثر غلظت مهاریEsophageal squamous cell carcinoma - کارسینوم سلول سنگفرشی مریEpithelial–mesenchymal transition - گذار اپیتلیال-مزانشیمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
c-Myc amplification-induced cell cycle dysregulation is a common cause for esophageal squamous cell carcinoma (ESCC), but no approved targeted drug is available so far. The bromodomain inhibitor JQ1, which targets c-Myc, exerts anti-tumor activity in multiple cancers. However, the role of JQ1 in ESCC remains unknown. In this study, we reported that JQ1 had potent anti-proliferative effects on ESCC cells in both time- and dose-dependent manners by inducing cell cycle arrest at G1 phase, cell apoptosis, and the mesenchymal-epithelial transition. Follow-up studies revealed that both c-Myc/cyclin/Rb and PI3K/AKT signaling pathways were inactivated by JQ1, as indicated by the downregulation of c-Myc, cyclin A/E, and phosphorylated Rb, AKT and S6. Tumor suppression induced by JQ1 in c-Myc amplified or highly expressed xenografts was higher than that in xenografts with low expression, suggesting its potential role in prediction. In conclusion, targeting c-Myc by JQ1 could cause significant tumor suppression in ESCC both in vitro and in vivo. Also, c-Myc amplification or high expression might serve as a potential biomarker and provide a promising therapeutic option for ESCC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 419, 10 April 2018, Pages 64-74
Journal: Cancer Letters - Volume 419, 10 April 2018, Pages 64-74
نویسندگان
Jingyuan Wang, Zhentao Liu, Ziqi Wang, Shubin Wang, Zuhua Chen, Zhongwu Li, Mengqi Zhang, Jianling Zou, Bin Dong, Jing Gao, Lin Shen,