Keywords: ANGPTL4; angiopoietin-like 4; CDX; CTC-derived xenograft; CK; cytokeratin; CNA; copy number alteration; CTC; circulating tumor cell; DAXX; death-associated protein 6; EMT; epithelial-mesenchymal transition; EpCAM; epithelial adhesion molecules; INDEL; ins
مقالات ISI (ترجمه نشده)
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Keywords: Histone methylation; Histone demethylation; Lung cancer; Histone methyltransferase; Histone demethylase; Inhibitors; ALK; anaplastic lymphoma kinase; DUSP3; dual-specificity phosphatase 3; Elk1; ETS-domain containing protein; EMT; epithelial-to-mesenchyma
Keywords: ARV-825 PubChem CID 92044400; BETd-246 PubChem CID 131698640; dBET1 PubChem CID 91799313; I-BET151 PubChem CID 52912189; I-BET762 PubChem CID 46943432; JQ1 PubChem CID 46907787; MS417 PubChem CID 59190723; OTX015 PubChem CID 9936746; THZ1 PubChem CID 7360
Keywords: ASO; antisense oligonucleotides; BANCR; BRAF-activated non-coding RNA; CCAT1-L; colorectal cancer associated transcript 1-long isoform; cET; constrained EThyl; EMT; epithelial to mesenchymal transition; ERV; endogenous retroviral sequence; FDA; food and d
Keywords: NSCLC; non-small-cell lung cancer; PDX; patient-derived xenograft model; ALK; anaplastic lymphoma kinase; YHIM; Yonsei Human In Mouse; MAF; mutant allele frequency; H&E; hematoxylin and eosin; Non-small-cell lung cancer; Patient-derived xenograft; Preclin
Keywords: MS; mass-spectrometry; NMR; nuclear magnetic resonance spectroscopy; MRS; magnetic resonance spectroscopy; D-2-HG; D-2-hydroxyglutarate; α-KG; α-ketoglutarate; OAA; oxaloacetic acid; TET; ten-eleven translocation; GSH; glutathione; ROS; reactive oxygen
Keywords: AICA; 5-aminoimidazole-4-carboxamide; AICARFTase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; CA; carbonic anhydrase; CBE; CI-HCO3â exchanger; CHO; Chinese hamster ovary; FR; folate receptor; GARFTase; β-glycinamide ribonucleotide
Keywords: Head and neck cancer; HNSCC; Patient derived xenograft; PDX; Mouse model;
Keywords: MAC; mucinous adenocarcinoma of the salivary gland; CSC; cancer stem cells; PDX; patient-derived xenografts; GEO; gene expression omnibus; TCGA; the cancer genome atlas; Cancer; Salivary mucinous adenocarcinoma; Metastases; Mutations; KRAS; TP53; KDM6A; K
Keywords: JAK; Janus kinase; STAT; signal transducers and activators of transcription; EPOR; erythropoietin receptor; TPOR; thrombopoietin receptor; G-CSFR; granulocyte colony stimulating factor receptor; γc; common gamma chain; SCID; severe combined immunodeficie
Keywords: PDX; (patient derived xenograft); UGM; (urogenital mesenchyme); AR; (androgen receptor); ER; (estrogen receptor); NEPC; (neuroendocrine prostate cancer); TURP; (transurethral resection of the prostate); TMPRSS2-ERG; (transmembrane protease serine 2, ETS-r
Keywords: 2D; two-dimensional; 3D; three-dimensional; CA; cancer; GEMM; genetically engineered mouse model; PC; pancreatic cancer; PDAC; pancreatic ductal adenocarcinoma,; PDX; patient-derived xenograft; TR; translational research; Translational research; Preclinic
Keywords: AASF; Antheraea assama silk fibroin; BC; benzalkonium chloride; BMP-2; bone morphogenetic protein-2; β-TCP; β-tricalcium phosphate; CDDP; cis-diamminedichloroplatinum; CMC; carboxymethylcellulose; E. coli; Escherichia coli; EGF; epidermal growth factor;
Keywords: Preclinical models; PDX; CDX; GEMMs; Tissue-slice cultures;
Keywords: AIF; Apoptosis-inducing factor; cDNA; complementary DNA; DIABLO; Direct IAP binding protein with low pI; EGF; Epidermal growth factor; GMCSF; Granulocyte Macrophage colony-stimulating factor; HER-2; Human epidermal growth factor receptor 2; IAP; Inhibitor
Keywords: ACL; ATP citrate lyase; Akt; Protein kinase B; ASCT2; Alanine, serine, cysteine-preferring transporter 2; ASS; Argininosuccinate synthetase; BMI; Body mass index; CAF; Cancer-associated fibroblasts; ER; Estrogen receptor; FASN; Fatty acid synthase; GPC; G
Keywords: ADT; androgen deprivation therapy; AR; androgen receptor; ASO; antisense oligonucleotide; CARN; castration-resistant Nkx3.1 expressing cells; CK; cytokeratin; CRPC; castration-resistant prostate cancer; DMBA; 7,12-dimethylbenz[a]anthracene; ECM; extracell
Keywords: 5-hydroxytryptamine; Tryptophan Hydroxylase; 5-HT2B; Pancreatic Intraepithelial Neoplasia; 5-HT; serotonin (5-hydroxytryptamine); CT; computed tomography; ECAR; extracellular acid ratio; HTRs; 5-HT receptors; KPC; KrasG12D/+/Trp53R172H/+/Pdx1-Cre; IHC; im
Keywords: Adipose tissue macrophages; Omega-3 PUFA; Protectin D1; Lipid mediators; Lipidomics; 2-AG; 2-arachidonoylglycerol; anandamide; N-arachi-donoylethanolamine; 17-HDHA; 17-hydroxy docosahexaenoic acid; ATMs; adipose tissue macrophages; CD11b; integrin αM cha
Keywords: ARA; arachidonic acid; DHA; docosahexaenoic acid; GOS; galactooligosaccharides; LCPUFA; long-chain polyunsaturated fatty acid; PDX; polydextrose; PPL; plasma phospholipid; RBC; red blood cell; SCO; single cell oil;
Keywords: Cancer stem cell; Hypothesis; Intratumor heterogeneity; Xenografts; PDX; Tumorigenicity;
Keywords: CM; conditioned medium; Cisplatin NP; without further indication, means anisamide targeted cisplatin NP; DRP; damage response program; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; FAPα; fibroblast activation protein alpha; GFP; gree
Keywords: %ID/g; percent injected dose per gram; 125I-FIAU; 125I-labeled fialuridine; 18F-FDG; 18F-labeled fluorodeoxyglucose; 18F-FLT; 18F-labeled fluorothymidine; 18F-FMT; 18F-labeled D-fluoromethyl tyrosine; ADC; apparent diffusion coefficient; BLI; bioluminesce
Keywords: Cancer models; Gene targeting; Transgenics; PDX; Cas9;
Keywords: ESFT; Ewing's sarcoma family tumors; ES; Ewing's sarcoma; MCTS; multicellular tumor spheroids; 3D; three-dimensional; PCL; poly(ε-caprolactone); ECM; extracellular matrix; PDX; patient-derived tumor explants; MSC; mesenchymal stem cells; EC; endothelial
Patient-Derived Xenograft Tumor Models: Overview and Relevance to IR
Keywords: PDX; patient-derived xenograft;
Effect of redox partner binding on CYP101D1 conformational dynamics
Keywords: Cyp101D1; P450cam; Arx; Pdx; Isothermal titration calorimetry;
Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
Keywords: 3D Organoids; Pancreas; Adenocarcinoma; Personalized Medicine; 3D; 3-dimensional; GEMMs; genetically engineered mouse models; PanIN; pancreatic intraepithelial neoplasia; PDAC; pancreatic ductal adenocarcinoma; PDX; patient-derived tumor xenografts;
Alpha, 2'-dihydroxy-4,4'-dimethoxydihydrochalcone inhibits cell proliferation, invasion, and migration in gastric cancer in part via autophagy
Keywords: TEM; transmission electron microscope; DCFDA; dihydrodichloroï¬uorescein diacetate; MEK; mitogen activated protein kinase kinase; ERK; extracellular signal-regulated kinase; mTOR; mammalian target of rapamycin; ROS; reactive oxygen species; PDX; patient
Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression
Keywords: CSCC; cutaneous squamous cell carcinoma; PDX; patient-derived xenograft; RDEB; recessive dystrophic epidermolysis bullosa; SCC; squamous cell carcinoma; TGFβ; transforming growth factor-beta; VAF; variant allele frequency;
Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma
Keywords: Esophageal squamous cell carcinoma; Targeting c-Myc; JQ1; c-Myc amplification; Patient derived xenograft; ESCC; esophageal squamous cell carcinoma; BET; bromodomain and extra-terminal; IC 50; the half maximal inhibitory concentration; NGS; Next-Generation
Gemtuzumab Ozogamicin (GO) Inclusion to Induction Chemotherapy Eliminates Leukemic Initiating Cells and Significantly Improves Survival in Mouse Models of Acute Myeloid Leukemia
Keywords: GO; gemtuzumab ozogamicin; AML; acute myeloid leukemia; DA; daunorubicin/cytarabine; NSG; nonobese diabetic severe combined immunodeficiency gamma; PDX; patient-derived xenograft; LIC; leukemic-initiating cell; PB; peripheral blood; BM; bone marrow; IV; i
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
Keywords: 17AAG; 17-Allylamino-17-demethoxygeldanamycin; BCG; Bacillus Calmette-Guerin; DCF; 2â²,7â²-Dichlorofluorescin-diacetate; DLS; Dynamic light scattering; CI; Combination index; CBC; Complete blood count; Fa; Fraction affected; HIF-1α; Hypoxia induced fac
Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts
Keywords: PDX; patient-derived xenograft; TALs; tumor-associated lymphocytes;
Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-controlled, and crossover study
Keywords: Appetite; Energy intake; GLP-1; Insulin; Overweight; Satiation; CCK; cholecystokinin; CON-B; placebo at breakfast; CON-M; placebo at midmorning; EI; energy intake; GLP-1; glucagon-like peptide 1; PDX; polydextrose; PDX-B; verum (12.5Â g of PDX) at breakfa
SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts
Keywords: Ascorbic acid; Cholangiocarcinoma; ROS; SVCT-2; CC; cholangiocarcinoma; AA; ascorbic acid; ROS; reactive oxygen species; SVCT; sodium-dependent vitamin C transporter; NAC; N-acetyl-l-cysteine; CI; combination index; H2AX; histone 2AX; AMPK; adenosine mono
Original ArticleResveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model
Keywords: Pancreatic cancer; Resveratrol; Capsaicin; Sulforaphane; Bioactive food component; PDAC; Pancreatic ductal adenocarcinoma; BFCs; Bioactive Food Components or Compounds; BITC; Benzyl Isothiocyanate; ROS; Reactive Oxygen Species; CSC; Cancer Stem Cell; PDX;
EMICORON: A multi-targeting G4 ligand with a promising preclinical profile
Keywords: G4; G-quadruplex; TIFs; telomere-dysfunction induced foci; CRC; colorectal cancer; MTD; maximum tolerated dose; PDX; patient-derived xenografts; GEMM; genetically engineered mouse models; CI; combination index; MTS; multicellular tumor spheroids; TWI; tum
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation
Keywords: AP-1; activator protein 1; B94, TNFAIP2; TNF alpha induced protein 2; C/EBP; CCAAT-enhancer-binding protein; CCL; chemokine ligand; CEX-1; chemokine exodus protein 1; COX; cyclooxygenase; CXCL; chemokine (C-X-C motif) ligand; CYP; cytochrome P450 monooxyg
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling
Keywords: Mitochondrial Uncoupler; Treatment; Liver Cancer; Big Data; AFP; α-fetoprotein; CDC37; cell division cycle 37; CCLE; Cancer Cell Line Encyclopedia; CMap; Connectivity Map; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; GEO; Ge
Insight into the contribution of isoprostanoids to the health effects of omega 3 PUFAs
Keywords: AA; arachidonic acid; ALA; α-linolenic acid; APCI; atmospheric pressure chemical ionization; ApoB100; apolipoprotein B100; BHT; butylated hydroxytoluene; BSTFA; bis-(trimethylsilyl)trifluoroacetamide; CCl4; tetrachloromethane; CNS; central nervous system
Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition
Keywords: Cancer Stem Cell (CSC); Targeted Therapy; Biologic; Anti-Tumor Agent; CSC; cancer stem cell; EAC; esophageal adenocarcinoma; EMT; epithelial to mesenchymal transition; Erb-b2/HER/ERBB; human epidermal growth factor receptor; FACS; fluorescence-activated c
Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25Â years of research in chemistry and biology
Keywords: Isoprostanes; Neuroprostanes; Phytoprostanes; Lipid Peroxidation; Polyunsaturated fatty acids; AA; Arachidonic acid; AD; Alzheimer's disease; AdA; Adrenic acid; ALA; α-Linolenic acid; APCI; Atmospheric pressure chemical ionization; BHT; Butylated hydroxy
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma
Keywords: BRCA1/2; BRCA1 or BRCA2; CDK; cyclin-dependent kinase; FBS; heat-inactivated fetal bovine serum; HGSOC; high-grade serous ovarian carcinoma; HR; homologous recombination; IP; intraperitoneal; pADPr; poly(ADP-ribose) polymer; PARP; poly(ADP-ribose) polymer
Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models
Keywords: Volitinib; cMET; PDX; Gastric cancer; Tyrosine kinase inhibitor; Small molecule;
Advances in patient-derived tumor xenografts: From target identification to predicting clinical response rates in oncology
Keywords: PDX; patient derived xenograft; CDX; cell line derived xenograft; CRD; clinically relevant dose; TIC; tumor initiating cell; NSG; NOD scid gamma; NSCLC; non-small cell lung cancer; CSC; cancer stem cell; SOC; standard of care; MTD; maximum tolerated dose;
Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse
Keywords: Breast cancer; Patient derived xenografts; Genetic stability; Adverse prognosis; PDX; patient derived xenografts; CNC; copy number changes; CGH; comparative genomic hybridization; RFS; recurrence free survival;
Phase II Trial of Pralatrexate (10-Propargyl-10-deazaaminopterin, PDX) in Patients with Unresectable Malignant Pleural Mesothelioma
Keywords: Pralatrexate; 10-Propargyl-10-deazaaminopterin; PDX; Mesothelioma; Antifolate;