کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7238714 1471144 2018 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
چکیده انگلیسی
HSP90 inhibitor, 17-AAG, loaded nanoporphyrin formed a “triple whammy” to eradicate bladder cancers via photodynamic therapy, photothermal therapy, and targeted therapy. Prolonged tumor accumulation of HSPP90 inhibitors not only efficiently prevented the photo-therapy induced HIF1α, but also down-regulated several essential signaling molecules, such as Akt, Src, and Erk in bladder cancer resulting in superior anti-cancer effect in patient derived xenograft model.335
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 14, Issue 3, April 2018, Pages 789-799
نویسندگان
, , , , , , , , , , , , , , , , , ,