Keywords: 17-آلملین-17-demethoxygeldanamycin; Ion channel trafficking; Drug-induced trafficking defects; Clinical relevance; QTc; Pro-arrhythmia; Pharmacological correction; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; AP; action potential; AV block; atrioventricular block; ECG; electrocardiogram;
مقالات ISI 17-آلملین-17-demethoxygeldanamycin (ترجمه نشده)
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Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17AAG; 17-Allylamino-17-demethoxygeldanamycin; BCG; Bacillus Calmette-Guerin; DCF; 2â²,7â²-Dichlorofluorescin-diacetate; DLS; Dynamic light scattering; CI; Combination index; CBC; Complete blood count; Fa; Fraction affected; HIF-1α; Hypoxia induced fac
Virtual screening and biophysical studies lead to HSP90 inhibitors
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG); ADP; adenosine diphosphate; AMPPCP; 5â²-adenylylmethylenediphosphonate; ASP; Astex statistical potential; ATP; adenosine triphosphat
BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; ALP; autophagy-lysosome pathway; AR; androgen receptor; ATXN1; ataxin-1; DMSO; dimethyl sulfoxide; DRPLA; dentatorubral pallidoluysian atrophy; HD; Huntington's disease; HSE; heat shock element; HSF1; heat
Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival
Keywords: 17-آلملین-17-demethoxygeldanamycin; Heat shock protein; Retina; Ganglion cells; Optic nerve; Glaucoma; Neuroprotection; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; AAV; adeno-associated virus; AD; Alzheimer's disease; Aβ; amyloid-β; ER; endoplasmic reticulum; GCL; ganglion cell layer;
Extracellular heat shock protein 90 binding to TGFβ receptor I participates in TGFβ-mediated collagen production in myocardial fibroblasts
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17AAG; 17-allylamino-17-demethoxygeldanamycin; SB431542; 4-(5-benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate; FITC-Ge or GE; FITC-Geldanamycin; TAC; transverse aortic constriction; RRL; rabbit reticulocyte lysate; Extracellular
Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG; 17-Allylamino-17-demethoxygeldanamycin; Cmpd; compound; CNS; central nervous system; fEPSP; evoked postsynaptic field potential; HSF1; heat-shock factor 1; HSP; heat-shock protein; Occ50; 50% occupancy; p.o.; peroral dosing; HSP70; HSP90; Occupanc
Molecular chaperones and neuronal proteostasis
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena
Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy
Keywords: 17-آلملین-17-demethoxygeldanamycin; Hsp90; Heat shock protein 90; Cdc37; Cell division cycle 37; AngII; Angiotensin II; TGFβ; Transforming growth factor β; ECM; Extracellular matrix; TβR-I; Transforming growth factor β receptor-I; TβR-II; Transforming growth factor β receptor-II; 17AA
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; CDK; cyclin dependent kinase; CHX; cycloheximide; CO; carbon monoxide; CoPP; cobalt protoporphyrin IX; FePP; ferric protoporphyrin IX; GA; geldanamycin; HO-1; heme oxygenase-1; HSP90; heat shock protein 90;
Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity
Keywords: 17-آلملین-17-demethoxygeldanamycin; γPKC; protein kinase Cγ; SCA14; spinocerebellar ataxia type 14; Hsp70; heat-shock protein 70; Hsp40; heat-shock protein 40; Hsp90; heat-shock protein 90; GFP; green fluorescent protein; PCs; Purkinje cells; WT; wild-type; LDH; lactate dehydrogenase; CHI
Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; BCS; bovine calf serum; C/EBPα; CCAAT element binding protein α; FABP4; fatty acid-binding protein 4; FACS; fluorescence-activated cell sorting; FAS; fatty acid synthase; FBS; fetal bovine serum; Hsp90; he
Toward understanding Machado-Joseph disease
Keywords: 17-آلملین-17-demethoxygeldanamycin; ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind
Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor
Keywords: 17-آلملین-17-demethoxygeldanamycin; Acute myeloid leukemia; KIT; Heat shock protein 90; Histone deacetylase inhibitor; 17-Allylamino-17-demethoxygeldanamycin; Two-hit
High cytotoxic sensitivity of the oligodendrocyte precursor cells to HSP90 inhibitors in cell cultures
Keywords: 17-آلملین-17-demethoxygeldanamycin; 17-AAG, 17-allylamino-17-demethoxygeldanamycin; GFAP, glial fibrillary acidic protein; HSP90, heat shock protein 90; OPCs, oligodendrocyte precursor cellsHeat shock protein 90; HSP90 inhibitors; Geldanamycin; 17-allylamino-17-demethoxygeldanamycin; Radici
A Cremophor-Free Formulation for Tanespimycin (17-AAG) Using PEO-b-PDLLA Micelles: Characterization and Pharmacokinetics in Rats
Keywords: 17-آلملین-17-demethoxygeldanamycin; geldanamycin; poly(ethylene oxide)-b-poly(d,l-lactide); Cremophor EL; poly meric micelle; pharmacokinetics; 17-AAG; 17-allylamino-17-demethoxygeldanamycin;
17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines
Keywords: 17-آلملین-17-demethoxygeldanamycin; hsp90; 90Â kDa heat-shock protein; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; DR4 and DR5; death receptors 4 and 5, respectively; CI; combination index; DISC; death-inducing signaling co