Keywords: مانع Hsp90; HSP90 inhibitor; Oaxazepine; Diazepine; Macrocycle; Structure based design;
مقالات ISI مانع Hsp90 (ترجمه نشده)
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Keywords: مانع Hsp90; Benzenoid/benzoquinone ansamycin; Reblastatin; Total synthesis; Hsp90 inhibitor;
Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors
Keywords: مانع Hsp90; Hsp90 inhibitor; Lung cancer; Resistance; Small molecule; Drug design;
Phase 2 Study of the HSP-90 Inhibitor AUY922 in Previously Treated and Molecularly Defined Patients with Advanced Non-Small Cell Lung Cancer
Keywords: مانع Hsp90; NSCLC; AUY922; HSP90 inhibitor; EGFR mutation; KRAS mutation; ALK rearrangement;
Discovery of novel HSP90 inhibitors that induced apoptosis and impaired autophagic flux in A549 lung cancer cells
Keywords: مانع Hsp90; Coumarin; Pyrazoline; HSP90 inhibitor; Lung cancer cell; Apoptosis; Autophagy;
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
Keywords: مانع Hsp90; 17AAG; 17-Allylamino-17-demethoxygeldanamycin; BCG; Bacillus Calmette-Guerin; DCF; 2â²,7â²-Dichlorofluorescin-diacetate; DLS; Dynamic light scattering; CI; Combination index; CBC; Complete blood count; Fa; Fraction affected; HIF-1α; Hypoxia induced fac
Original ArticleThe HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer
Keywords: مانع Hsp90; NSCLC; HSP90 inhibitor; PI3K inhibitor; KRAS mutation; Combination therapy; NSCLC; non-small cell lung cancer; CI; combination index;
Original ArticleHSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2
Keywords: مانع Hsp90; Small cell lung cancer; BCL-2 inhibitor; HSP90 inhibitor; Combination therapy; CI; combination index; SCLC; small cell lung cancer;
Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway
Keywords: مانع Hsp90; 3-MA; 3-methyladenine; CQ; chloroquine diphosphate; DMSO; dimethyl sulfoxide; Hsp; heat shock protein; LC3; microtubule-associated protein light chain 3; LDH; lactate dehydrogenase; NH4Cl; ammonium chloride; Autophagy; Cardiotoxicity; Hsp90 inhibitor; Hum
HSP90 inhibitor NVP-AUY922 induces cell apoptosis by disruption of the survivin in papillary thyroid carcinoma cells
Keywords: مانع Hsp90; PTC; HSP90 inhibitor; NVP-AUY922; Apaptosis; Survivin;
Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors
Keywords: مانع Hsp90; Diarylisoxazole; Resorcinol; Amino acid; Hsp90 inhibitor; Antiproliferative effect; PBOJNUMPLKSXOR-JDQQTNDFSA-N; WPHBATTWJIGEQR-VGHOESRUSA-N;
4,5,6,7-Tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine as a new scaffold for heat shock protein 90 inhibitors
Keywords: مانع Hsp90; Hsp90 inhibitor; Anticancer drug; Resorcinol; Tetrahydrotriazolopyrazine
Ocular toxicity of AUY922 in pigmented and albino rats
Keywords: مانع Hsp90; HSP90 inhibitor; AUY922; Ocular toxicity; Rodents; Histopathology; Electroretinography
Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity
Keywords: مانع Hsp90; Caged xanthones; Hsp90 inhibitor; Antitumor; Anti-angiogenesis; Gambogic acid;
The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib
Keywords: مانع Hsp90; NSCLC; HSP90 inhibitor; MEK inhibitor; KRAS mutation; Combination therapy;
Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation
Keywords: مانع Hsp90; Nanotechnology; Cancer chemotherapy; Hsp90 inhibitor; Nano formulation; 17AAG;
Dendritic hexadecapeptide as a cathepsin B degradable carrier for delivery of HSP90 inhibitor
Keywords: مانع Hsp90; Geldanamycin; Degradable polymer; HSP90 inhibitor; Cathepsin B; Peptidic dendrimer
Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors
Keywords: مانع Hsp90; HSP90; 3,5-Disubstitute-4-alkynylisoxazole; HSP90 inhibitor;
Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors
Keywords: مانع Hsp90; Hsp90 inhibitor; Natural product; Epigallocatechin gallate
The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine
Keywords: مانع Hsp90; HSP90 inhibitor; 17-AAG; Edelfosine; Cell cycle arrest; Apoptosis-like cell death; Leishmania spp.;
BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation
Keywords: مانع Hsp90; Hsp90; Hsp90 inhibitor; BIIB021; Esophageal squamous cell carcinoma; Radiosensitivity;
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma
Keywords: مانع Hsp90; PU-H71; HSP90 inhibitor; Bortezomib; Ewing sarcoma;
Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors
Keywords: مانع Hsp90; Structure-based drug design; Lead optimization; Antitumor agent; Hsp90 inhibitor
Phosphorylation accelerates geldanamycin-induced Akt degradation
Keywords: مانع Hsp90; Hsp90 inhibitor; Akt; CHIP; Phosphorylation;
Inhibition of gastric tumor growth by a novel Hsp90 inhibitor
Keywords: مانع Hsp90; 17-AAG; 17-allylamino-17-demethoxyl-geldanamycin; co-IP; co-immunoprecipitation; GA; geldanamycin; Hsp90; heat shock protein 90; IDF; induced fit docking; Hsp90; Hsp90 inhibitor; Gastric cancer; Cancer therapy; Molecular chaperone;
Can RNAi-mediated hsp90α knockdown in combination with 17-AAG be a therapy for glioma?
Keywords: مانع Hsp90; Hsp90α; Tat; sihsp90α/CPP complex; Cell penetrating peptides; Glioblastoma; GBM; Hsp90 inhibitor; Akt; Cell-cycle arrest;
Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors
Keywords: مانع Hsp90; Herpes simplex virus (HSV); HSP90 inhibitor; Antivirals
The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor
Keywords: مانع Hsp90; Hsp90; Hsp90 inhibitor; 17-DMAG; Gefitinib; EGFR mutation; EGFR-TKI; Acquired resistance
Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Keywords: مانع Hsp90; Structure-based drug design; Lead optimization; Macrocyclic molecule; Antitumor agent; Hsp90 inhibitor;
Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation
Keywords: مانع Hsp90; Hsp90; heat shock protein 90; HCV; hepatitis C virus; RdRp; RNA-dependent RNA polymerase; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; PDK1; phosphoinositide-dependent kinase-1; PRK2; protein kinase C-related kinase 2; Hsp90 inhibitor;
HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells
Keywords: مانع Hsp90; Hepatitis C virus (HCV) core protein; Yeast growth defect caused by core protein; HSP90 inhibitor; Stability nascent polypeptide; HSC90; High-throughput screening;
SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells
Keywords: مانع Hsp90; SNX-2112; Hsp90 inhibitor; Hsp90 client proteins; Apoptosis; Autophagy; A-375
Broad action of Hsp90 as a host chaperone required for viral replication
Keywords: مانع Hsp90; Hsp90; Antiviral; Chaperone; Drug resistance; Hsp90 inhibitor; Virus, protein folding;
Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins
Keywords: مانع Hsp90; Heat shock protein 90; Activator of Hsp90 ATPase; Non-receptor tyrosine kinase v-Src; Progesterone receptor; Aha1-interacting protein; Hsp90 inhibitor;
Approaches for defining the Hsp90-dependent proteome
Keywords: مانع Hsp90; Hsp90-interactome; Proteomics; LC-MS/MS; High-throughput screen; Hsp90 inhibitor;
Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone
Keywords: مانع Hsp90; Hsp90 inhibitor; Structure-based design technique; Pyrrolopyrimidine
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Keywords: مانع Hsp90; Virtual screening; Fragment-based approach; Hsp90 inhibitor
BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway
Keywords: مانع Hsp90; Hsp90 inhibitor; BJ-B11; Chronic myeloid leukemia; Apoptosis; Mitochondrial dysfunction
A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells
Keywords: مانع Hsp90; Hsp90 inhibitor; C-terminal; Melanoma
Antifungal metabolites (monorden, monocillins I, II, III) from Colletotrichum graminicola, a systemic vascular pathogen of maize
Keywords: مانع Hsp90; Anthracnose; Biotrophy; Hsp90 inhibitor; Necrosis; Radicicol;
Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses
Keywords: مانع Hsp90; Hsp90 inhibitor; Chaperone; Vesicular stomatitis virus; Paramyxovirus; SV5; La Crosse virus; Antiviral; Polymerase
From the bench to the bedside: emerging new treatments in multiple myeloma
Keywords: مانع Hsp90; myeloma; targeted therapy; immunomodulatory; thalidomide; lenalidomide; bortezomib; hsp90 inhibitor
Novel nontoxic heat shock protein 90 inhibitors having selective antiproliferative effect
Keywords: مانع Hsp90; Anticancerogen; Hsp90 inhibitor; Peptide-derivative; Selective activity; 3D molecular structure
Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation
Keywords: مانع Hsp90; Hsp90 inhibitor; C-terminal domain; Small molecule probes; Allostery; In silico modeling; Prostate cancer therapeutic;
Structure-based discovery of a new class of Hsp90 inhibitors
Keywords: مانع Hsp90; Hsp90 inhibitor; Docking; Virtual screening; Hit identification; Phenol–naphthol; Bis-phenol; Structure-based drug discovery