Broad action of Hsp90 as a host chaperone required for viral replication

► Viruses are intracellular pathogens responsible for a vast number of human diseases. ► The molecular chaperone Hsp90 is nearly universally required for viral protein replication. ► The unique characteristics of viral replication cause viruses to be hypersensitive to pharmacological inhibitors of Hsp90. ► The ubiquitous requirement for Hsp90 provides a novel therapeutic avenue for development of broad-spectrum antiviral drugs.