Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

► Aha1 interacts with Hsp90, Hsp70, DNAJA1, p23 and FKBP52, but not with Cdc37 or HOP. ► Aha1 does not appear to modulate Hsp90-dependent folding of nascent polypeptides. ► Over-expression of Aha1 does not stimulate Hsp90's chaperone activity. ► Aha1 may function in regulation of proteins involved in cellular stress responses.