Keywords: پروتئین درمانی; Glycosylation; Glycoform; Nucleotide sugars; Biosimilar; Immune effector functions; mAbs; Therapeutic protein; Glutamine; Ammonia; Animal cell culture;
مقالات ISI پروتئین درمانی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: پروتئین درمانی; 2D-LC; two-dimensional liquid chromatography; AA; amino acid; AC; affinity chromatography; ADC; antibody-drug conjugates; ADCC; antibody-dependent cellular cytotoxicity; AF4; asymmetric flow field fractionation; APTS; 1-aminopyrene-3,6,8-trisulfonate; Asn
Keywords: پروتئین درمانی; Therapeutic protein; Formulation; Excipient; Kinetic model; Aggregation mechanism; Protein unfolding;
Keywords: پروتئین درمانی; TPP; therapeutic protein product; ADA; anti-drug antibody; mAb; monoclonal antibody; RA; rheumatoid arthritis; MS; multiple sclerosis; IBD; inflammatory bowel disease; NAb; neutralizing ADA; non-NAb; non-neutralizing ADA; PK; pharmacokinetics; PRCA; pure
Keywords: پروتئین درمانی; Disposable bioreactor; Escherichia coli; Human CD83 (hCD83); Recombinant protein production; Rocking bioreactor; Therapeutic protein
Keywords: پروتئین درمانی; Biopharmaceutical; Characterization; Hydrophilic interaction chromatography (HILIC); Ion-exchange chromatography (IEX); Mass spectrometry (MS); Monoclonal antibody (mAb); Reversed-phase liquid chromatography (RPLC); Size-exclusion chromatography (SEC); Th
Keywords: پروتئین درمانی; Process systems modelling; Quality by design; Chromatography modelling; Hydrophobic interaction chromatography; Purification process development; Therapeutic protein;
Keywords: پروتئین درمانی; Chromatography; Mass spectrometry; Biopharmaceutical; Monoclonal antibody; Therapeutic protein
In vitro models for immunogenicity prediction of therapeutic proteins
Keywords: پروتئین درمانی; Therapeutic protein; Immunogenicity assessment; In vitro model; Subcutaneous injection; Injection site reactions; ADAs; antidrug antibodies; ALN; artificial lymph node; APCs; antigen presenting cells; ASCs; adipose-derived stem/stromal cells; DCs; dendrit
Site-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivo
Keywords: پروتئین درمانی; Non-natural amino acid; Site-specific albumination; Therapeutic protein; Urate oxidase; Strain-promoted azide-alkyne cycloaddition
Soluble expression and partial purification of recombinant human erythropoietin from E. coli
Keywords: پروتئین درمانی; rhEpo; Escherichia coli expression system; Maltose binding protein (MBP); Therapeutic protein;
An experimental framework for improved selection of binding proteins using SNAP display
Keywords: پروتئین درمانی; Protein engineering; Therapeutic protein; SNAP display; Directed evolution; In vitro compartmentalization; In vitro selection;
Analytical approaches to assess the degradation of therapeutic proteins
Keywords: پروتئین درمانی; Analytical technique; Chemical change; Conformational change; Degradation; Drug; Instability; Product development; Protein aggregate; Protein degradation; Therapeutic protein
Metabolism and metabolic burden by α1-antitrypsin production in human AGE1.HN cells
Keywords: پروتئین درمانی; Mammalian cell; Cell culture; Biopharmaceutical; Metabolic flux; AAT deficiency; Therapeutic protein
Expression of the Apelin-APJ Pathway and Effects on Erectile Function in a Mouse Model of Vasculogenic Erectile Dysfunction
Keywords: پروتئین درمانی; Erectile Dysfunction; Endothelial Dysfunction; Apelin; Therapeutic Protein; Angiogenesis;
Effect of Intracavernous Administration of Angiopoietin‐4 on Erectile Function in the Streptozotocin‐Induced Diabetic Mouse
Keywords: پروتئین درمانی; Erectile Dysfunction; Diabetes Mellitus; Endothelial Dysfunction; Angiogenesis; Therapeutic Protein; Angiopoietin‐4; Enhanced Responsiveness to PDE5 Inhibitors
Bioanalytical LC–MS/MS of protein-based biopharmaceuticals
Keywords: پروتئین درمانی; Bioanalysis; LC–MS; Monoclonal antibodies; Therapeutic protein; Absolute quantification; Sample preparation
Galactose can be an inducer for production of therapeutic proteins by auto-induction using E. coli BL21 strains
Keywords: پروتئین درمانی; Auto-induction; Escherichia coli BL21; Galactose; Fed-batch fermentation; Therapeutic protein;
Downregulation of CD40 Signal and Induction of TGF-β by Phosphatidylinositol Mediates Reduction in Immunogenicity Against Recombinant Human Factor VIII
Keywords: پروتئین درمانی; Biotechnology; Phospholipids; Nanoparticle; Therapeutic protein; Immunogenicity; Immunology; Dendritic cell; Cell-culture; Co-stimulatory signal; Transforming Growth Factor-β;
Structural characterization of protein–polymer conjugates. I. Assessing heterogeneity of a small PEGylated protein and mapping conjugation sites using ion exchange chromatography and top-down tandem mass spectrometry
Keywords: پروتئین درمانی; PEGylated protein; Therapeutic protein; Covalent modification; Mass spectrometry; Ion fragmentation, top-down; Ion exchange chromatography
On the role of salt type and concentration on the stability behavior of a monoclonal antibody solution
Keywords: پروتئین درمانی; Protein aggregation; Therapeutic protein; Hofmeister effect; Protein-salt interaction; Solvation forces;
Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the α1-antitrypsin producing human AGE1.HN cell line
Keywords: پروتئین درمانی; Mammalian cell; Therapeutic protein; AAT deficiency; Nitrogen metabolism; Biopharmaceutical; Metabolic flux analysis
Metabolite channeling and compartmentation in the human cell line AGE1.HN determined by 13C labeling experiments and 13C metabolic flux analysis
Keywords: پروتئین درمانی; Mammalian cell; Pyruvate metabolism; Therapeutic protein; Biopharmaceutical production; Metabolic flux analysis
Molecular manipulation associated with disulfide bond formation to enhance the stability of recombinant therapeutic protein
Keywords: پروتئین درمانی; Disulfide bond; Escherichia coli; Human CD83; Protein stability; Therapeutic protein
Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures
Keywords: پروتئین درمانی; Bioreactor; Bioprocess engineering; Plant cell culture; Protein production; Recombinant protein; Therapeutic protein
Human growth hormone–transferrin fusion protein for oral delivery in hypophysectomized rats
Keywords: پروتئین درمانی; Fusion protein; Human growth hormone; Transferrin; Oral delivery; Therapeutic protein
Novel self-cleavage activity of Staphylokinase fusion proteins: An interesting finding and its possible applications
Keywords: پروتئین درمانی; Staphylokinase; Self-cleavage activity; Fusion protein; Therapeutic protein; GST fusion
Structural identification of recombinant human CD83 mutant variant as a potent therapeutic protein
Keywords: پروتئین درمانی; Dendritic cell (DC); Escherichia coli; CD83; Gene expression; Protein purification; Therapeutic protein
Safety of prolonged, repeated administration of a pulmonary formulation of tissue plasminogen activator in mice
Keywords: پروتئین درمانی; Pulmonary drug delivery; Therapeutic protein; Plastic bronchitis; Experimental lung injury; Fibrinolysis; Lung clearance; Gender differences;
Intracavernous Delivery of Synthetic Angiopoietin-1 Protein as a Novel Therapeutic Strategy for Erectile Dysfunction in the Type II Diabetic db/db Mouse
Keywords: پروتئین درمانی; Diabetes-Related Erectile Dysfunction; Endothelial Dysfunction; Angiogenesis; Therapeutic Protein; Angiopoietin-1;
A sensitive and high-throughput LC–MS/MS method for the quantification of pegylated-interferon-α2a in human serum using monolithic C18 solid phase extraction for enrichment
Keywords: پروتئین درمانی; LC–MS/MS; Therapeutic protein; Quantification; Pegylated-interferon; PEG-IFN; Human serum; Monolithic SPE
Plant N-glycan profiling of minute amounts of material
Keywords: پروتئین درمانی; Plant glycosylation; N-Glycan profiling; Glycoprotein; Therapeutic protein
The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model
Keywords: پروتئین درمانی; Pharmacokinetics; Lymphatic uptake; Therapeutic protein; Insulin; Erythropoietin
Immunogenicity of therapeutic proteins. Part 3: Impact of manufacturing changes
Keywords: پروتئین درمانی; Biopharmaceutical; Therapeutic protein; Biosimilar; Immunogenicity; Manufacturing changes; Epoetin; PRCA
Immunogenicity of therapeutic proteins. Part 2: Impact of container closures
Keywords: پروتئین درمانی; Biopharmaceutical; Therapeutic protein; Biosimilar; Immunogenicity; Container closures; Epoetin; PRCA
Detection of antibodies against therapeutic proteins in the presence of residual therapeutic protein using a solid-phase extraction with acid dissociation (SPEAD) sample treatment prior to ELISA
Keywords: پروتئین درمانی; Antibody; Anti-drug; Biotin extraction; Acid dissociation; Therapeutic protein; Nonclinical; ELISA; Drug interference
Immunogenicity of therapeutic proteins. Part 1: Impact of product handling
Keywords: پروتئین درمانی; Biopharmaceutical; Therapeutic protein; Biosimilar; Immunogenicity; Neutralizing antibody; Epoetin; PRCA
Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein
Keywords: پروتئین درمانی; Accelerator mass spectrometry; Therapeutic protein; ELISA; Anti-TGFß1 monocloncal antibody; Radiolabelled protein
A non-covalent peptide-based strategy for protein and peptide nucleic acid transduction
Keywords: پروتئین درمانی; Cell-penetrating peptide; Therapeutic protein; Peptide delivery; Peptide nucleic acid; Amphipathic peptide; Peptide-based nanoparticle
Transgenic chickens as bioreactors for protein-based drugs
Keywords: پروتئین درمانی; Drug Discovery; Pharmaceutical Science; Biochemistry; Biotechnology; Therapeutic protein; Post-translational modification; Glycosylation; Production flock; Retroviral vector; Gene transfer;