Keywords: AP-1; activator protein 1; DAMP; damage associated molecular patterns; IRAK1; interleukin-1 receptor associated kinase-1; LBP; LPS binding protein; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MD2; myeloid differentiation factor 2; MHC
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Keywords: Pattern-recognition receptors (PRRs); Toll-like receptors (TLRs); RIG-I-like receptors (RLRs); NOD-like receptors (NLRs); Small molecule modulators; BIR; baculovirus inhibitor repeat; CARD; caspase recruitment domains; CFS; chronic fatigue syndrome; CLR;
Keywords: Apaf1; apoptotic peptidase activating factor 1; Casp7; caspase-7; Ccnd2; Cyclin D2; Cdc20; cell division cycle 20 homolog; IEC; intestinal epithelial cells; Kdr; kinase insert domain receptor; Pten; phosphatase and tensin homolog; Mcm2; minichromosome mai
Keywords: COPD; chronic obstructive pulmonary disease; DAMPs; damage-associated molecular patterns; DC; dendritic cells; IFN; interferon; IKK (IKB); inhibitor kappa B kinase; IL; interleukins; MHC; major histocompatibility complex; MyD88; myeloid differentiation pr
Keywords: AD; Alzheimer's disease; TLRs; toll-like receptors; AβPP; amyloid-β protein precursor; NSAIDs; non-steroidal anti-inflammatory drugs; CNS; central nervous system; TNF-α; tumor necrosis factor-α; IL-1β; interleukin 1-β; IL-6; interleukin-6; NO; nit
Keywords: AP-1; activator protein; CD14; cluster of differentiation 14; ERK; extracellular signal-regulated kinase; IκBα; inhibitor of NFκB; IKK; inhibitor of NFκB kinase; IRAK; IL-1 receptor-associated kinase; IRF; interferon regulatory factor; JNK; c-Jun N-te
Keywords: ACP5; Acid phosphatase 5; ADAR1; Adenosine deaminase RNA-specific 1; AGS; Aicardi-Goutières syndrome; ALRs; AIM2-like receptors; AIM2; Absent in melanoma 2; ASC; Apoptosis-associated speck-like protein containing a CARD; CANDLE; Chronic atypical neutroph
Keywords: BBB; blood-brain barrier; DAMPs; danger associated molecular patterns; EP; ethyl pyruvate; GFP; green fluorescent protein; Hb; hemoglobin; HIF1á; hypoxia-inducible factor-1á; HMGB1; high mobility group box 1 protein; HO; heme oxygenase; HUCB; human um
Keywords: CD14; cluster of differentiation 14; dsRNA; double stranded ribonucleic acid; IFN; interferon; IL; interleukin; IRAK; interleukin-1 receptor-associated kinase; IRF3; interferon regulatory factor 3; LBP; lipopolysaccharide-binding protein; LPS; lipopolysac
Keywords: ACTDs; autoimmune connective tissue diseases; SLE; systemic lupus erythematosus; RA; rheumatoid arthritis; SSc; systemic sclerosis; SS; Sjögren's syndrome; MCTD; mixed connective tissue disease; TLRs; IL-1R-like receptors; DAMPs; danger-associated molecu
Keywords: TIRAP; Polymorphism; TNF-α; Meta-analysis; P. falciparum malaria
Molecular mechanism of LPS-induced TNF-α biosynthesis in polarized human macrophages
Keywords: TTP; tristetraprolin; TRIF; TIR-domain-containing adapter-inducing interferon-β; TRAM; TRIF-related adapter molecule; IRF3; interferon regulatory factor 3; IFNAR; interferon-α/β receptor; ActD; actinomycin D; TIRAP; TIR-domain-containing adapter protei
MicroRNA regulation of Toll-like receptor signaling pathways in teleost fish
Keywords: MicroRNA; Toll-like receptors; Fish; Immune response; AP-1; activator protein; CCR3; CC chemokine receptor 3; CDS; coding region; COX2; cyclooxygenase-2 enzyme; CQ; chloroquine; ER; endoplasmic reticulum; Flg 22; amino-terminal fragment of flagellin; GCRV
Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses
Keywords: BMMCs; bone marrow-derived mast cells; Csk; C-terminal Src kinase; IRF; IFN-regulated factor; Mal; myeloid differentiation factor 88 (MyD88)-adapter-like; SFK; Src-family kinase; TIR domain; Toll/IL-1R (TIR) domain; Tirap; toll-interleukin 1 receptor (TIR
Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia
Keywords: TGFi; TGF induced factor homeobox; TGF; transforming growth factor; IL1; interleukin 1; IL1i; IL1 inhibitors; IL1RL1; interleukin 1 receptor like 1; TNF; tumor necrosis factor; Nogo; reticulon 4 (RTN4/Nogo); NGF; nerve growth factor; STC; stanniocalcin 1;
Anti-inflammatory mechanisms of neovestitol from Brazilian red propolis in LPS-activated macrophages
Keywords: Natural products; Propolis; Cytokines; Inflammation; Nutraceutical; Neovestitol (PubChem CID44257510); BRP; Brazilian red propolis; DAMP; danger-associated molecular patterns; MAMP; microbe-associate molecular patterns; TIRAP; Toll-Interleukin 1 Receptor;
Phosphatidylinositol 4-phosphate 5-kinase α contributes to Toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid
Keywords: GFP; green fluorescent protein; IκB; inhibitor of κB; IL; interleukin; iNOS; inducible nitric oxide synthase; JNK; c-Jun N-terminal kinase; KD; knockdown; KO; knockout; LPS; lipopolysaccharide; LTA; lipoteichoic acid; MAPK; mitogen-activated protein kin
Association of TLR polymorphisms with bronchopulmonary dysplasia
Keywords: BPD; Bronchopulmonary dysplasia; TIRAP; Toll-interleukin 1 receptor domain-containing adaptor protein; SNPs; Single nucleotide polymorphisms; TLRs; Toll-like receptors; NICU; Neonatal intensive care unit; NICHD; The National Institute of Child Health and
Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation
Keywords: TLR; Toll-like receptor; NLR; Nod-like receptor; iNOS; inducible NO synthase; PMC; peritoneal mesothelial cell; poly(I:C); polyinosinic-polycytidylic acid; TIR; Toll/IL-1 receptor; TIRAP; TIR domain-containing adapter protein; TRIF; TIR domain-containin
Role of lipid microdomains in TLR-mediated signalling
Keywords: ABCA1/G1; ATP-binding cassette, sub-family A/G, member 1; AP-1; activator protein 1; CARC; inverted “CRAC” domain; CD 14/36/55; cluster of differentiation 14/36/55; CRAC; cholesterol recognition amino-acid consensus sequence; CXCR4; C-X-C chemokine re
Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood
Keywords: IL33-IL1RL1 pathway; asthma; wheezing phenotypes; children; IL1RL1; IL33; Avon Longitudinal Study of Parents and Children study; Prevalence and Incidence of Asthma and Mite Allergy study; ALSPAC; Avon Longitudinal Study of Parents and Children; eQTL; Expr
TIRAP C539T polymorphism contributes to tuberculosis susceptibility: Evidence from a meta-analysis
Keywords: TIRAP; MAL; Polymorphism; Tuberculosis; Meta-analysis;
Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106
Keywords: MAL; TIRAP; BTK; PKCδ; Protein–protein interactions (PPIs); Tyr86; Tyr106; Adenosine triphosphate (ATP)
Activation of c-Src: A hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling
Keywords: ONS; oxidative/nitrosative stress; TLR; Toll-like receptor; HEK; human embryonic kidney; MD; myeloid of differentiation; Ca-pY; caffeic acid-pYEEIE; CD; cluster of differentiation; Eb; ebselen; MPLA; monophosphoryl lipid A; LPS-EK; lipopolysaccharide
Aberrant TIRAP and MyD88 expression in B-cell chronic lymphocytic leukemia
Keywords: TIRAP; MyD88; TLR; B-CLL; IL-6;
PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress
Keywords: CoCl2; cobalt chloride; DIC; differential interference contrast; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine perchlorate; GSK-3; glycogen synthase kinase 3; HIF-1; hypoxia-inducible factor-1; LPS; lipopolysaccharide; Mal; MyD88 adapt
Toll-like receptor 4-, 7-, and 8-activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines
Keywords: Bruton tyrosine kinase; X-linked agammaglobulinemia; Toll-like receptors; MyD88 adapter-like protein; Toll-IL-1 receptor domain-containing adapter protein; BTK; Bruton tyrosine kinase; CVID; Common variable immunodeficiency; ERK; Extracellular signal-
Toll-like receptors in chronic pain
Keywords: TLRs; Toll-like receptors; ERK; extracellular signal-regulated kinase; JNK; c jun N-terminal kinase; IL; interleukin; TNF-α; tumor necrosis factor-α; PGE2; prostaglandin E2; GLT1; glutamate transporter 1; GLAST; glutamate aspartate transporter; LPS; lip
FcεRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcεRIβ chain
Keywords: ITAM; immunoreceptor tyrosine-based activation motif; CD; circular dichroism; BMMCs; bone marrow-derived mast cells; TNP; trinitrophenyl; GST; glutathione S-transferase; TLR; toll-like receptor; TIRAP; toll/IL-1R-containing adaptor protein; IKK; IκB kina
Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility
Keywords: TIRAP; Polymorphism; Susceptibility; Tuberculosis; Meta-analysis
Comparative and phylogenetic analyses of three TIR domain-containing adaptors in metazoans: Implications for evolution of TLR signaling pathways
Keywords: Comparative genomics; TICAM-1; TICAM-2; TIRAP; Shark
Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India
Keywords: TLR; TIRAP; Gene polymorphisms; Tuberculosis
TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus
Keywords: TIRAP; Mal; Tuberculosis; Systemic lupus erythematosus; Rheumatoid arthritis; Sjögren's syndrome; Type 1 diabetes mellitus
Conservation of Toll-like receptor signaling pathways in teleost fish
Keywords: Pro-inflammatory cytokine; Interferon; MYD88; TIRAP; TRIF; TRAF6; IRF3; Phylogeny; Molecular tree; PHYLIP
Toll-Like Receptor Signaling in the Liver
Keywords: ER; endoplasmic reticulum; LPS; lipopolysaccharide; LRR; leucine-rich repeat; PAMPs; pathogen-associated molecular patterns; PH; partial hepatectomy; SOCS1; suppressing of cytokine signaling 1; TIR; Toll/interleukin-1 receptor; TIRAP; TIR domain containin
Suppression of macrophage responses to bacterial lipopolysaccharide (LPS) by secretory leukocyte protease inhibitor (SLPI) is independent of its anti-protease function
Keywords: IkB; inhibitor for NF-κB; IKK; IkB kinase; IRAK; IL-1 receptor associated kinase; MyD88; myeloid differentiation antigen 88; SLPI; secretory leukocyte protease inhibitor; TIR; toll IL-1 receptor; TIRAP; TIR domain-containing adapter protein; TRAF; TNF re
Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses-and viruses counteract IFN action
Keywords: Interferons; Innate antiviral immunity; Interferon-regulatory factor; Toll-like receptors; AP-1; activating protein 1; CARD; caspase recruitment domain; CpG DNA; unmethylated double-stranded DNA; DC; dendritic cell; dsRNA; double-stranded RNA; GAS; IFN ga