Keywords: AP-1; activator protein 1; DAMP; damage associated molecular patterns; IRAK1; interleukin-1 receptor associated kinase-1; LBP; LPS binding protein; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MD2; myeloid differentiation factor 2; MHC
مقالات ISI (ترجمه نشده)
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Keywords: 5FU; fluorouracil 5%; CMOBC; cutaneous metastases of breast cancer; MBC; metastatic breast cancer; TLR7; toll-like receptor 7; antitumor immunity; breast cancer; cryotherapy; cutaneous metastases; fluorouracil; imiquimod; in situ vaccination; skin-direct
Keywords: 17 alpha-methyltestosterone; Innate immunity; Nile tilapia; Gene expression; Monosex fish; MT; 17 alpha-methyltestosterone; 11-kT; 11-ketotestosterone; EDCs; endocrine disrupting chemicals; E2; 17 β-estradiol; EE2; 17 α-ethinyl estradiol; il1β; interle
Keywords: PRRSV; TLR7; Antivirus factor; ISGs; NF-κB;
Keywords: Pigeon; TLR7; LRR insertion; Mutational analysis; Innate immunity;
Keywords: Chinese giant salamander; TLR7; Expression profile; Iridovirus
Keywords: Diversity-oriented synthesis; Imidazoheterocyclic; Groebke-Blackburn-Bienayme reaction; Fused imidazole; Lewis acid; Ugi type; Ac; acetyl; Aq; aqueous; Ar; aryl; Bn; benzyl; Boc; tert-butoxycarbonyl; BDMS; bromodimethylsulfonium bromide; CDK; cyclin-d
Differences in TLR7/8 activation between monocytes and macrophages
Keywords: TLR7; TLR8; Monocytes; Macrophages; Immune modulation; AP-1; activator protein 1; cDNA; complementary DNA; ELISA; enzyme-linked immunosorbent assay; FBS; fetal bovine serum; HEPES; hydroxyethyl piperazineethanesulfonic acid; IFN; interferon; IL-6; interle
Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulation
Keywords: Nanoparticle; Immunostimulation; Resiquimod; TLR7;
Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists
Keywords: HBV; TLR7; Quinazoline;
Systemic inflammation in asocial BTBR T+ tf/J mice predisposes them to increased psoriatic inflammation
Keywords: Autism; BTBR T+ tf/J mice; TLR7; Th17; Psoriasis; Dendritic cells;
Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B
Keywords: Hepatitis B virus; HBsAg; Immune response; TLR7;
Temporal cytokine and lymphoid responses to an inhaled TLR7 antedrug agonist in the cynomolgus monkey demonstrates potential safety and tolerability of this approach
Keywords: TLR7; AZD8848; Asthma; Cynomolgus; Safety assessment; Antedrug; BALF; bronchoalveolar lavage fluid; BALT; bronchus-associated lymphoid tissue; CRP; C reactive protein; MALT; mucosa-associated lymphoid tissue; NALT; nose-associated lymphoid tissue;
GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways
Keywords: Enterovirus 71; Hand; Foot and mouth disease; GS-9620; NF-κB and PI3K-AKT signaling pathways; EV71; Human enterovirus 71; TLR7; Toll-like receptor 7; NF-κB; nuclear factor kappa B; PI3K; phosphoinositide 3-kinase; hpi; hours post infection;
TLR7 polymorphism, sex and chronic HBV infection influence plasmacytoid DC maturation by TLR7 ligands
Keywords: Plasmacytoid dendritic cell; TLR7; rs179008; Sex; Hepatitis B virus; Immunotherapy;
Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist
Keywords: Nanoparticles; Papaya mosaic virus; Plasmacytoid dendritic cells; TLR7; TLR8 adjuvant; Cancer immunotherapy; PapMV; papaya mosaic virus; ssRNA; single stranded RNA; VLNP; virus-like nanoparticles; CP; coat protein; PBMC; peripheral blood mononuclear cells
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism
Keywords: TLR7; GS-9620; Hepatitis B virus; Interferon-alpha; cccDNA; Interferon-stimulated gene; MHC; Immunoproteasome; APOBEC; Smc5/6;
Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells
Keywords: TLR7; Hepatitis B virus; Immunomodulation; Chimpanzee animal model; CD8 T cell; B cell; NK cell; Interferon-alpha; Interferon-stimulated gene; Lymphocyte aggregate; Tertiary lymphoid structure;
Hepatitis C virus inhibits CD4 T cell function via binding to Toll-like receptor 7
Keywords: TLR7; CD4; HCV; IRS661; Imiquimod; TLR-7; Toll-like receptor 7; ssRNA; single stranded RNA; DC; dendritic cells; HCVcc; culture-derived hepatitis C virus; IFNγ; interferon gamma; ORNs; RNA oligonucleotides; HCV; hepatitis C virus; IMQ; imiquimod; PBMC; p
Combined immunotherapy: CTLA-4 blockade potentiates anti-tumor response induced by transcutaneous immunization
Keywords: TCI; transcutaneous immunization; CTL; cytotoxic T-cell; TLR7; toll-like receptor 7; CTLA-4; cytotoxic T-lymphocyte associated antigen 4; s.c; subcutaneous; i.p.; intraperitoneal; Treg; regulatory T-cell; IFN; interferon; IL; interleukin; APC; antigen pre
TLR7 deficiency contributes to attenuated diabetic retinopathy via inhibition of inflammatory response
Keywords: Diabetic retinopathy; TLR7; Inflammation; NF-κB; MAPKs;
Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model
Keywords: Pertussis; Vaccine; Adjuvant; TLR7; Protective immunity;
Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis
Keywords: Treg; regulatory T-cell; CatS; cathepsin S; CatK; cathepsin K; CatL; cathepsin L; PD-L1; programmed death ligand 1; PTEN; phosphatase and tensin homolog; TLR7; toll-like receptor-7; WT; wild-type; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP
Potential role of IL-17-producing CD4/CD8 double negative αβ T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model
Keywords: ILC; innate lymphoid cells; MAIT cell; mucosal associated invariant T cell; IMQ; imiquimod; TLR7; Toll-like receptor; TPA; tumor promoter 12-O-tetradecanoylphorbol-13-acetate; DN αβ T cells; αβ-TCR+ CD4CD8 double negative T cells; RORγt; retinoic aci
Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation
Keywords: AKT; protein kinase B; AP-1; activator protein-1; BV-2; immortalized murine microglia cell line; CD11b; cluster of differentiation 11b; CD36; cluster of differentiation 36; CD44; cluster of differentiation 44; CD68; cluster of differentiation 68; CNS; cen
Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism
Keywords: TLR9; TLR7; Inflammation; Antagonist; Homology model; Drug design; Computational analysis; FGDQSWJQAISDMB-UHFFFAOYSA-N;
Rabies virus lipopeptide conjugated to a TLR7 agonist improves the magnitude and quality of the Th1-biased humoral immune response in mice
Keywords: TLR7; Imiquimod; Lipopeptide; Rabies vaccine; Adjuvant;
Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice
Keywords: MF; total flavonoids extracted from Mosla Scabra; IAV; influenza A virus; LD50; 50% lethal dose; RFQ-PCR; Real-time Fluorescence Quantitative Polymerase Chain Reaction; IC50; 50% influenza virus-inhibitory concentration; HDF-1; 5-hydroxy-6,7-dimethoxyflav
Btk inhibition treats TLR7/IFN driven murine lupus
Keywords: Btk; Bruton's tyrosine kinase; TLR7; Toll-like receptor 7; BCR; B cell receptor; FcR; Fc receptor; SLE; systemic lupus erythematosus; IFN; interferon; FACS; fluorescence-activated cell sorting; MMF; mycophenolate mofetil; Lupus; Bruton's tyrosine kinase;
Functional polymorphisms of the TLR7 and TLR8 genes contribute to Mycobacterium tuberculosis infection
Keywords: TLR7; TLR8; Polymorphisms; TB; Phagocytosis;
TLR7, IFNγ, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity
Keywords: Gender; Autoimmunity; TLR7; T-bet; IFNgamma; ABCs
Molecular cloning, tissue distribution, and immune function of goose TLR7
Keywords: Goose; TLR7; Innate immunity; NGVEV
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers
Keywords: BAFF; Systemic lupus erythematosus; TACI; TLR7; Autoantibodies; Lupus nephritisANA, anti-nuclear autoantibodies; APRIL, a proliferation-inducing ligand; BAFF, B cell-activating factor of the TNF family; BAFFR, BAFF receptor; BCMA, B cell maturation antige
Research ArticleSustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
Keywords: CHB; chronic hepatitis B; TLR7; toll-like receptor 7; WHV; woodchuck hepatitis virus; HBV; hepatitis B virus; WHsAg; WHV surface antigen; HCC; hepatocellular carcinoma; IFN-α; interferon-alpha; HBsAg; hepatitis B surface antigen; HBsAb; anti-HBs antibody
Study of toll-like receptor 7 expression and interferon α in Egyptian patients with chronic hepatitis C Infection and Hepatocellular Carcinoma
Keywords: TLRs; TLR7; HCV; HCC; IFN-α; Innate immunity; Viral hepatitis; Viral load
Toll-like receptor 7 variations are associated with the susceptibility to HCV infection among Chinese females
Keywords: HCV; hepatitis C virus; TLR7; Toll-like receptor 7; SNP; single nucleotide polymorphism; HCC; hepatocellular carcinoma; PRR; pattern recognition receptor; PAMP; pathogen associated molecular pattern; ssRNA; single strand RNA; HIV; human immunodeficiency v
An anti-interferon activity shared by paramyxovirus C proteins: Inhibition of Toll-like receptor 7/9-dependent alpha interferon induction
Keywords: IFN; interferon; PIVs; parainfluenza viruses; MeV; measles virus; NiV; Nipah virus; ORF; open reading frame; SeV; Sendai virus; ISGs; IFN-stimulated genes; ds; double stranded; PKR; protein kinase R; PAMPs; pathogen-associated molecular patterns; IRF; int
The role of MyD88 signaling in heterosubtypic influenza A virus infections
Keywords: Influenza A virus; Heterosubtypic; MyD88; TLR7; T-cell; Antibody;
Molecular characterization and expression analysis of TLR 7 and TLR 8 homologs in large yellow croaker (Pseudosciaena crocea)
Keywords: Large yellow croaker (Pseudosciaena crocea); TLR7; TLR8; Subcellular localization; Poly (I:C);
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility
Keywords: TLR7; Interferon; Innate immunology; Solubility; Antitumor
Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
Keywords: SARS; Viral pathogenesis; ssRNA; TLR7; TLR8; Inflammation
Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2 genes in Atlantic salmon (Salmo salar)
Keywords: Toll-like receptor; TLR7; TLR8; Atlantic salmon; Innate immunity; Gene expression
Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages
Keywords: TGF-β; Tumor-associated macrophages; Functional re-programming; TLR4; TLR7
Atlantic halibut experimentally infected with nodavirus shows increased levels of T-cell marker and IFNγ transcripts
Keywords: T-cell receptor; TCRβ; CD4; CD4-2; CD8α; CD8β; Lck; ZAP-70; Interleukin; IL-1β; IL-6; IL-11; IL-12β; IFNγ; Toll like receptor; TLR7; ISG15; Mx; Teleost; Fish; NNV; AHNV; VER; Concanavalin A; PMA; ConA; Imiquimod;
A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core
Keywords: TLR7; Negishi; Carbamates; Heterocycles;
Toward self-adjuvanting subunit vaccines: Model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines
Keywords: Imidazoquinoline; Toll-like receptor; TLR7; Self-adjuvanting vaccine; ELISA; Adjuvant
Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke
Keywords: CT, Computed Tomography; mRS, modified Rankin Scale; ECG, Electrocardiogram; NIHSS, National Institute of Health Stroke Scale; Ct, Cycle threshold; CRP, C-Reactive ProteinIschemic stroke; Toll-like receptor; Outcome; TLR7; TLR8
TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism
Keywords: Histamine; Neutrophil; Histidine decarboxylase; TLR4; TLR7; Granule;
Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists
Keywords: Toll-like receptor; TLR7; TLR8; Imidazoquinoline; NOESY; HIV; Autoimmune diseasesCD, cluster of differentiation; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DMAP, 4-dimethylaminopyridine; DMF, N,N-dimethylformamide; ESI-TOF, electrospray ionization-time of f