کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5540986 | 1553614 | 2017 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The extent to which immunity, apoptosis and detoxification gene expression interact with 17 alpha-methyltestosterone
ترجمه فارسی عنوان
میزان ایمنی، آپوپتوز و بیان ژن سم زدایی با 17 آلفا-متیل تستوسترون ارتباط دارد
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کلمات کلیدی
TNFα11-KTCASDPHVitellogeninEE2TLR7IL811-ketotestosterone - 11-کتواستاسترون17 β-Estradiol - 17 β-اترادیولEDCs - EDC هاIL1β - IL1bInnate immunity - ایمنی ذاتیinterferon - اینترفرونIFN - اینترفرون هاinterleukin 1 beta - اینترلوکین 1 بتاInterleukin 8 - اینترلوکین 8Gene expression - بیان ژنtumour necrosis factor alpha - تومور نکروز عامل آلفاNile tilapia - تیلاپیای نیلdays post-hatching - روز بعد از اخراجEndocrine Disrupting Chemicals - مواد شیمیایی خرابکار غدد درون ریزvtg - ویتگtoll-like receptor 7 - گیرنده شماره 7
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
چکیده انگلیسی
Innate immunity is the first line of defence against invasion by foreign pathogens. One widely used synthetic androgen for the production of all-male fish, particularly commercially valuable Nile tilapia, Oreochromis niloticus, is 17 alpha-methyltestosterone (MT). The present study investigates the effect of MT on innate immunity, cellular apoptosis and detoxification and the mortality rate, during and after the feeding of fry with 0-, 40-and 60-mg MT/kg. Expression analysis was completed on interleukin 1 beta (il1β), interleukin 8 (il8), tumour necrosis factor alpha (tnfα), CXC2- and CC-chemokines, interferon (ifn), myxovirus resistance (mx), toll-like receptor 7 (tlr7), immunoglobulin M heavy chain (IgM heavy chain), vitellogenin (vtg), cellular apoptosis susceptibility (cas) and glutathione S-transferase α1 (gstα1). Expression analysis revealed that MT had a significant impact on these genes, and this impact varied from induction to repression during and after the treatment. Linear regression analysis showed a significant association between the majority of the tested gene transcript levels and mortality rates on the 7th and 21st days of hormonal treatment and 2 weeks following hormonal cessation. The results are thoroughly discussed in this article. This is the first report concerning the hazardous effect of MT on a series of genes involved in immunity, apoptosis and detoxification in the Nile tilapia fry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 60, January 2017, Pages 289-298
Journal: Fish & Shellfish Immunology - Volume 60, January 2017, Pages 289-298
نویسندگان
Haitham G. Abo-Al-Ela, Abeer F. El-Nahas, Shawky Mahmoud, Essam M. Ibrahim,