Topoisomerases interlink genetic network underlying autism
Keywords: توپویزومراز; Topoisomerase; Neurodevelopment; ASD
مقالات ISI توپویزومراز (ترجمه نشده)
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Molecular modelling approach to evaluate poisoning of topoisomerase I by alternariol derivatives
Keywords: توپویزومراز; AOH; alternariol; AME; alternariol-methyl ether; ALT; altenuene; iALT; isoaltenuene; LBVS; ligand based virtual screening; Topo; topoisomerase; Topo I; topoisomerase I; Topo II; topoisomerase II; Molecular modelling; Alternaria metabolites; Alternariol; P
Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases
Keywords: توپویزومراز; 2-Arylquinazolinone; 3-Arylisoquinoline; Topoisomerase; Cytotoxicity; Molecular docking;
Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition
Keywords: توپویزومراز; 3,4-Diarylisoquinoline; Suzuki coupling; Selective cytotoxicity; Topoisomerase; Molecular docking
Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity
Keywords: توپویزومراز; topo; topoisomerase; cSDR; constitutive stable DNA replication; RNase HI; ribonuclease H1; EdU; ethynyl deoxyuridine; R-loop; Topoisomerase; topA; topB; rnhA; RNase H;
Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells
Keywords: توپویزومراز; Cancer stem-like cell; Drug resistance; CD44; Co-delivery; Topoisomerase;
Synthesis, biological evaluation and modeling studies of terphenyl topoisomerase IIα inhibitors as anticancer agents
Keywords: توپویزومراز; Terphenyls; Topoisomerase; 3D-QSAR;
Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIα by its cytotoxic β-carboline alkaloids
Keywords: توپویزومراز; Galianthe; Galianthe thalictroides; β-Carboline alkaloids; Topoisomerase; SRB assay
Novel synthetic acridine-based derivatives as topoisomerase I inhibitors
Keywords: توپویزومراز; Acridine; DNA binding agent; Topoisomerase; Anticancer
Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity
Keywords: توپویزومراز; Acridines; Antimicrobials; SAR; MRSA; Intercalation; Amphiphiles; Drug design; Synthesis; Topoisomerase;
Shikonin shortens the circadian period: Possible involvement of Top2 inhibition
Keywords: توپویزومراز; Transcription; Circadian rhythm; Topoisomerase; Clock genes;
Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
Keywords: توپویزومراز; TDP1; Assay; High-throughput screen; Fragment; Inhibitor; Topoisomerase;
A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation
Keywords: توپویزومراز; Topoisomerase; Topoisomerase IIα; Topoisomerase IIβ; High-throughput assay; Fluorescence anisotropy;
Pyrroloquinolinone-based dual topoisomerase I/II inhibitor
Keywords: توپویزومراز; Topoisomerase; Dual activity; Pyrroloquinolinone; Molecular docking
Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers
Keywords: توپویزومراز; Demethylepipodophyllotoxin; Topoisomerase; Cytotoxicity;
Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors
Keywords: توپویزومراز; DNA gyrase; Topoisomerase; Antibacterial; Synthesis; In vivo; Dual-targeting;
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
Keywords: توپویزومراز; R-loops; Genome instability; Double-strand breaks; G-quadruplex; Topoisomerase; THO/TREX complex; THSC/TREX-2; ASF splicing factor; mRNP biogenesis; RNA processing factors; RNase H; RNA:DNA helicases; Senataxin; Activation-induced deaminase (AID); APOBEC
DNA binders in clinical trials and chemotherapy
Keywords: توپویزومراز; XDJLAOSHOBCPPI-WUBUUNPKSA-N; ARSFQWCDXUGXIU-VXWGTAJRSA-N; VKXQUANKCRVCKT-TVHGLRORSA-N; OJLGBWUBPLHGPO-UHFFFAOYSA-T; Duplex DNA; G-quadruplex DNA; DNA binders; Topoisomerase; Chemotherapy; Clinical trials; Anticancer;
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors
Keywords: توپویزومراز; DNA gyrase; Topoisomerase; Antibacterial;
Mechanism study of goldenseal-associated DNA damage
Keywords: توپویزومراز; Berberine; Comet assay; DNA damage; Goldenseal; γ-H2A.X; Topoisomerase;
A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα
Keywords: توپویزومراز; Topoisomerase; DNA relaxation; Fluorescence anisotropy; High-throughput; Inhibitor;
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation
Keywords: توپویزومراز; hTop1B; human topoisomerase 1B; CPT; camptothecin; TPT; topotecan; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; DTT; dithiothreitol; BSA; bovine serine albumin; TBE; tris-borate-EDTA; PMSF; pheny
A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition
Keywords: توپویزومراز; Terphenyls; Topoisomerase; Suppressors; Apoptosis;
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors
Keywords: توپویزومراز; Mansonone E; Antitumour; Click chemistry; Topoisomerase; Cytotoxic activity; HPLC; High Performance Liquid Chromatography; HRMS; High Resolution Mass Spectrometer; MTT; methyl thiazolyl tetrazolium; NMR; nuclear magnetic resonance; Topo; topoisomerase; ME
A fluorescence-based assay for the apurinic/apyrimidinic-site cleavage activity of human tyrosyl-DNA phosphodiesterase 1
Keywords: توپویزومراز; Tdp1; DNA repair; Assay; High-throughput screen; Inhibitor; Topoisomerase
Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives
Keywords: توپویزومراز; Anticancer activity; Indenoquinolines; Photoisomerization; Topoisomerase
Synthesis and biological evaluation of new 9-aminoacridine-4-carboxamide derivatives as anticancer agents : 1st Cancer Update
Keywords: توپویزومراز; 9-Aminoacridine-4-carboxamide; Lung cancer; Cervical cancer; MTT assay; Topoisomerase
Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity
Keywords: توپویزومراز; Anti-tumor; Ciprofloxacin; Chalcone; Topoisomerase; Hybrids
Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors
Keywords: توپویزومراز; Topoisomerase; Gyrase; ATPase; Inhibitor; Fluoroquinolone; Ciprofloxacin
Antitumor agents 294. Novel E-ring-modified camptothecin–4β-anilino-4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents
Keywords: توپویزومراز; Topoisomerase; Cytotoxicity; Camptothecin (CPT); Etoposide (VP-16); Epipodophyllotoxin; Conjugates
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth
Keywords: توپویزومراز; Endocannabinoid; 2-Arachidonoylglycerol; Monoacylglycerol lipase; Topoisomerase; Maleimide
Nuclear export of proteins and drug resistance in cancer
Keywords: توپویزومراز; CRM1; Drug resistance; Nuclear export signal; Nuclear pore complex; Topoisomerase
Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action
Keywords: توپویزومراز; Peltodon longipes; Abietane diterpenes; Cytotoxicity; MIA PaCa-2; Topoisomerase; Molecular modelling; Cell cycle; DNA damage; Apoptosis;
Sequence analysis of topoisomerase gene of pseudocowpoxvirus isolates from camels (Camelus dromedarius)
Keywords: توپویزومراز; Pseudocowpoxvirus; Topoisomerase; PCR; Camel
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases
Keywords: توپویزومراز; Topoisomerase; Alkaloid; Anticancer; Antibacterial; Pancratium illyricum L.
Topoisomerase I/II inhibition by a novel naphthoquinone containing a modified anthracycline ring system
Keywords: توپویزومراز; Topoisomerase; Chemotherapeutic; Napthaquinone; Anthracycline; Enzyme inhibition
High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay
Keywords: توپویزومراز; Yeast; Topoisomerase; ATPase; DNA; GST;
Benzoquinazoline derivatives as new agents affecting DNA processing
Keywords: توپویزومراز; Antitumor agents; Benzoquinazoline; DNA; Topoisomerase
Differential gene expression activity among species-specific polypyrimidine/polypurine motifs in mu opioid receptor gene promoters
Keywords: توپویزومراز; MOR, mu opioid receptor; CD, circular dichroism; PPy/u, polypyrimidine/polypurine; NHE III1, c-Myc nuclease hypersensitive element III1Gene expression; Homologous PPy/u Motifs; Mu opioid receptor; Spectroscopy; Topoisomerase
The polypyrimidine/polypurine motif in the mouse mu opioid receptor gene promoter is a supercoiling-regulatory element
Keywords: توپویزومراز; MOR, mu opioid receptor; PPy/u, polypyrimidine/polypurine; NHE III1, c-Myc nuclease hypersensitive element III1Gene expression; Homologous PPy/u motifs; Mu opioid receptor; Supercoiling-regulatory element; Topoisomerase
Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents
Keywords: توپویزومراز; SKPRIJWVEDRIOT-BQYQJAHWSA-N; OOOUBTWYQQAQFN-OWOJBTEDSA-N; HAYSPOCTKYOUCB-UHFFFAOYSA-N; WNVGQEMFZKUSTF-UHFFFAOYSA-N; VNYDXEMIMZMHQE-OWOJBTEDSA-N; PNPRCRFPOPRPNR-UHFFFAOYSA-N; WHUQGTNSJGDHHT-UHFFFAOYSA-N; GMVGQYMQJCJUMH-UHFFFAOYSA-N; YGZMSSQJSOSLPO-UHFFFAOY
Inhibition of topoisomerase IIα: Novel function of wedelolactone
Keywords: توپویزومراز; Apoptosis; DNA damage; Proliferation; Topoisomerase; Wedelolactone
TopR2, the Second Reverse Gyrase of Sulfolobus solfataricus, Exhibits Unusual Properties
Keywords: توپویزومراز; Archaea; topoisomerase; reverse gyrase; thermophile; DNA supercoilingEDTA, ethylenediaminetetraacetic acid; TEP, Tris–sodium phosphate–EDTA
A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition
Keywords: توپویزومراز; Propionyloxy derivative of KBA; HL-60; Boswellia serrata; Topoisomerase; Caspase;
Cytotoxic 3,6-bis((imidazolidinone)imino)acridines: Synthesis, DNA binding and molecular modeling
Keywords: توپویزومراز; Proflavine; DNA-intercalation; Antitumor; Topoisomerase; Modeling;
Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-Nâ²-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives
Keywords: توپویزومراز; Nitrogen heterocycles; Carbazole; Indole; Friedel-Crafts; DNA binding; Topoisomerase;
Mechanism of hydrolysis of a novel indolocarbazole topoisomerase I inhibitor
Keywords: توپویزومراز; Hydrolysis; Topoisomerase; Indolocarbazole
Liquid chromatography–tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776
Keywords: توپویزومراز; Indenoisoquinolines; Tandem mass spectrometry; Topoisomerase; Assay; Validation
Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor
Keywords: توپویزومراز; NB, neuroblastoma; cMAP, connectivity map; EAD, Epoxy anthraquinone derivativeNeuroblastoma; Anti-cancer drug; Microarray; cMAP; Topoisomerase; EAD
Synthesis and cancer cell cytotoxicity of substituted xanthenes
Keywords: توپویزومراز; Xanthene; Xanthone; Cytotoxicity; Cancer cells; MCF-7; DU-145; HeLa; SAR; Topoisomerase; DNA binding; Intercalation; Drug design; Molecular modeling