Cytotoxic 3,6-bis((imidazolidinone)imino)acridines: Synthesis, DNA binding and molecular modeling

Synthesis, DNA binding and fragmentation, topoisomerase inhibition, antitumor activity, and modeling of novel 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)imino)acridine hydrochlorides 6a-6e are reported.