دانلود مقالات ISI درباره Trypanothione + ترجمه فارسی

تجزیه و تحلیل کنترل متابولیک مسیر سمزدایی پراکسید کربیز تریپانوزومای کریزی، تریپاریدوکسین را به عنوان یک هدف مناسب دارو معرفی می کند

Metabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug target

Keywords: CJai; flux control coefficient; CumOOH; cumene hydroperoxide; GPxA; tryparedoxin-dependent glutathione peroxidase A; MCA; Metabolic Control Analysis; TryR; trypanothione reductase; TryS; trypanothione synthetase; T(SH)2; trypanothione; TXN; tryparedoxin;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

دیابنزوآبیریل جایگزین پلی آمینها و آنالوگهای کلومیفرمین به عنوان مهارکنندههای مهار کننده تریپانوتیونی ردوکتاز؛ تکینگی مولکولی و ارزیابی فعالیت های تریپانو اسیلیک

Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities

Keywords: TR; trypanothione reductase; GR; glutathione reductase; DBS; dibenzosuberyl, 10,11-dihydro-5H-dibenzo[a,d]cycloheptenyl; DBA; 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepinyl; T(SH)2; trypanothione dithiol; T(S)2; trypanothione disulfide; BR; binding region

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of 2-methyl-1H-benzimidazole-5-carbohydrazides derivatives as modifiers of redox homeostasis of Trypanosoma cruzi

Keywords: Nfx; nifurtimox; Bnz; benznidazole; GR; glutathione reductase; MDA; malondialdehyde; GSH; glutathione; GSSG; glutathione disulfide; T(SH)2; trypanothione; Trypanosoma cruzi; Benzimidazole; Oxidative stress; Chagas disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony

Keywords: Leishmania guyanensis; Ornithine decarboxylase; Gamma-glutamylcysteine synthetase; Antimony-resistance; Trypanothione; Lg; Leishmania guyanensis; ODC; ornithine decarboxylase; GSH1; gamma-glutamylcysteine synthetase; SbIII; trivalent antimony; DFMO; α-di

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Hydrogen peroxide resistance in Strigomonas culicis: Effects on mitochondrial functionality and Aedes aegypti interaction

Keywords: SHTs; symbiont harboring trypanosomatids; ROS; reactive oxygen species; H2O2; hydrogen peroxide; O2•-; superoxide anion; TNX; tryparedoxin; GSH; glutathione; TSH2; trypanothione; ETC; electron transport chain; OXPHOS; oxidative phosphorylation; ROX; res

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress

Keywords: Amp B; Amphotericin B; APx; ascorbate peroxidase; CS; cysteine synthase; DTNB; 5,5`-dithiobis-(2-nitrobenzoic acid); FBS; fetal bovine serum; γ-GCS; γ-glutamylcysteine synthetase; GSH; glutathione; GST; glutathione S-transferase; LdCS; Leishmania donova

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase

Keywords: Trypanosoma cruzi; Trypanothione; Nitroheterocycle drugs; Nifurtimox;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei

Keywords: Trypanosoma brucei; Methionine; Tryparedoxin; Trypanothione; Recombinant protein expression; RNA interference; GFP;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Catalytic properties, localization, and in vivo role of Px IV, a novel tryparedoxin peroxidase of Trypanosoma brucei

Keywords: Trypanosoma brucei; Glutathione peroxidase; Tryparedoxin peroxidase; Gene deletion; Hydroperoxide metabolism; Trypanothione

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase

Keywords: Leishmania donovani; Trypanothione; Thiol metabolism; Tryparedoxin; Tryparedoxin peroxides; Drug resistance

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Interaction between cysteine synthase and serine O-acetyltransferase proteins and their stage specific expression in Leishmania donovani

Keywords: Cysteine synthase; Serine O-acetyltransferase; Leishmania; Enzyme kinetics; Trypanothione; Thiol metabolism; Amp B; amphotericin B; CS; cysteine synthase; CBS; cystathionine β-synthase; CGS; cystathionine γ-lyase; DTNB; 5,5′-dithiobis-(2-nitrobenzoic

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2016 سفارش ترجمه

Redox metabolism in Trypanosoma cruzi: Functional characterization of tryparedoxins revisited

Keywords: Grx; glutaredoxin; GR; glutathione reductase; TR; trypanothione reductase; T(SH)2; trypanothione; TS2; trypanothione disulfide; GSSG; glutathione disulfide; GSH; reduced glutathione; TXNPx; 2-Cys-peroxiredoxin-type tryparedoxin peroxidase; GPxI; glutathio

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2013 سفارش ترجمه

The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases

Keywords: Antioxidant defense; DNA synthesis; Drugability; Drug target; Leishmaniasis; Target validation; Trypanosomiasis; Trypanothione; Trypanothione synthetase; Tryparedoxin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Leishmaniasis: Vaccine candidates and perspectives

Keywords: VL; visceral leishmaniasis; IFN; interferon; IL; interleukin; CTL; cytotoxic T lymphocyte; CL; cutaneous leishmaniasis; CVL; canine visceral leishmaniasis; MPL-SE; monophosphoryl lipid A soluble emulsion; PV; parasitophorous vacuole; NET; neutrophil extra

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis

Keywords: ODC; ornithine decarboxylase; SAMDC; S-adenosylmethionine decarboxylase; ADC; arginine decarboxylase; NO; nitric oxide; NOS2; inducible nitric oxide synthase; Th1; T-helper type 1 lymphocytes; Th 2; T-helper type 2 lymphocytes; NOHA; Nω-hydroxy-l-arginin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Methylglyoxal metabolism in trypanosomes and leishmania

Keywords: GLO1; glyoxalase I; GLO2; glyoxalase II; T[SH]2; trypanothione, N1,N8-bis(glutathionyl)spermidine; GSH; glutathione; LADH; lactaldehyde dehydrogenase; Trypanosoma; Leishmania; Methylglyoxal; Glyoxalase; Trypanothione; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Enlightening the molecular basis of trypanothione specificity in trypanosomatids: Mutagenesis of Leishmania infantum glyoxalase II

Keywords: Leishmania infantum; Glyoxalase II; Trypanothione; Enzyme specificity shift; Enzyme kinetics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Functional characterization of methionine sulfoxide reductase A from Trypanosoma spp.

Keywords: GSH, reduced glutathione; L-MetSO, l-methionine sulfoxide; MSR, methionine sulfoxide reductase; TR, trypanothione reductase; TXNI, tryparedoxin I; T(SH)2, reduced trypanothioneTrypanosoma; Methionine sulfoxide; Trypanothione; Oxidative stress; Tryparedoxi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage

Keywords: T. brucei; Trypanosoma brucei; L. major; Leishmania major; wt; wild-type; Px; non-selenium glutathione peroxidase-type tryparedoxin peroxidase; TXNPx; 2-Cys-peroxiredoxin-type tryparedoxin peroxidase; TR; trypanothione reductase; Tpx; tryparedoxin; T(SH)2

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Leishmania-macrophage interactions: Insights into the redox biology

Keywords: 6PGDH; 6-phosphogluconate dehydrogenase; AMB; amphotericin-B; ASC; ascorbate; BH4; 5,6,7,8-tetrahydrobiopterin; CaM; calmodulin; CL; cutaneous leishmaniasis; DETA; diethylenetriamine; eEF1B; eukaryotic elongation factor 1B; eNOS or NOS3; endothelial nitri

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

Keywords: AMP-PNP; adenylyl imidodiphosphate; GS; glutathione synthetase; GSH; glutathione; HEPES; 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-hydroxyethyl)piperazine-N-(2-ethanesulfonic acid); MOPS; 3-(N-morpholino)-propanesulfonic acid; NCS; non-crys

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Preparative enzymatic synthesis of trypanothione and trypanothione analogues

Keywords: Trypanothione; Trypanothione synthetase; Trypanothione reductase; Crithidia fasciculata; Glutathionylspermidine; Drug development;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Keywords: Trypanothione; Trypanosoma; Thiol metabolism; Thioredoxin; Glutaredoxin; Tryparedoxin; Peroxiredoxin; Glutathionylation; Glutathione peroxidase

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

The effects by neuroleptics, antimycotics and antibiotics on disulfide reducing enzymes from the human pathogens Acanthamoeba polyphaga and Naegleria fowleri

Keywords: Human pathogens; Acanthamoeba polyphaga; Naegleria fowleri; Neuroleptics; Antimycotics; Antibiotics; Cysteine; Glutathione; Trypanothione; Disulfide reducing enzymes; Potential drug targets; T(S)2, oxidized trypanothione; Gspd, glutathione-spermidine; DTT

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host

Keywords: Review; Trypanosoma cruzi; Nifurtimox; Benznidazole; Glutathione; Trypanothione; Immune system; Natural antichagasic compounds; Macrophages; Nitric oxide; Prostaglandins

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2007 سفارش ترجمه

Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major

Keywords: GspS; glutathionylspermidine synthetase; TryS; trypanothione synthetase; T[SH]2; trypanothione; Synthetase; Domain; GlobPlot; Trypanothione; Thiol; Trypanosome;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

Keywords: Polyamine; Trypanothione; Trypanothione reductase; Trypanosome; Trypanosomiasis; Inhibitor; Antiparasitic; Guanidine; Biguanide

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Naegleria fowleri: A free-living highly pathogenic amoeba contains trypanothione/trypanothione reductase and glutathione/glutathione reductase systems

Keywords: Drug target; Naegleria fowleri; Cysteine; Glutathione; Trypanothione; Glutathione reductase; Trypanothione reductase; T(S)2, trypanothione disulphide; Gspd, glutathionyl-spermidine; MALDI-TOF, matrix assisted laser-desorption ionization-time-of-flight; mB

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه