دانلود مقالات ISI درباره Tspo + ترجمه فارسی

Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects

Keywords: Dentate gyrus; 18 kDa translocator protein; Allopregnanolone; Anxiety and depression; TSPO; 18 kDa translocator protein; CSF; plasma and cerebrospinal fluid; AP; anteroposterior; ML; mediolateral; DV; dorsoventral; i.p; intraperitoneally;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

Keywords: Translocator protein; TSPO; Mitochondrial permeability transition pore; Alzheimer's disease; Mitochondrial dysfunction; Aβ;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

GQSAR modeling and combinatorial library generation of 4-phenylquinazoline-2-carboxamide derivatives as antiproliferative agents in human Glioblastoma tumors

Keywords: GBM; Glioblastoma multiforme; TSPO; translocator protein; MPTP; mitochondrial permeability transition pore; ANT; adenine nucleotide transporter; VDAC; voltage dependent anion channel; QSAR; quantitative structure activity relationship; GQSAR; Group QSAR;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model

Keywords: 6-OHDA; 6-hydroxydopamine; AD; Alzheimer disease; BBB; blood-brain barrier; CL; contra-lateral; cpm; counts per min; DAPI; 4′-6-diamidino-2-phenylindole; FBS; fetal bovine serum certified; IL; ipsi-lateral; MEM; minimum essential media; nAChR; nicotin

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis

Keywords: Multiple sclerosis; Experimental autoimmune encephalomyelitis; XBD173; TSPO; Neurodegeneration; Neuroinflammation;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of brain regions predicting epileptogenesis by serial [18F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy

Keywords: Positron emission tomography; Temporal lobe epilepsy; [18F]GE-180; TSPO; Neuroinflammation; Predictive cluster VOI;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Metal complexes targeting the Translocator Protein 18 kDa (TSPO)

Keywords: ACBP; acyl coenzyme-A binding protein; AIF; apoptosis inducing factor; ANT; Adenine Nucleotide Translocase; B; boron; BDZ; benzodiazepine; BFC approach; bifunctional chelate approach; BNCT; Boron Neutron Capture Therapy; CBR; Central-type Benzodiazepine R

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2017 سفارش ترجمه

The translocator protein (18 kDa) and its role in neuropsychiatric disorders

Keywords: 3α-HSD; 3α-hydroxysteroid dehydrogenase; 3β-HSD; 3β-hydroxysteroid dehydrogenase/Δ5−Δ4; AIF; apoptosis inducing factor; AD; Alzheimer's disease; ANT; adenine nucleotide translocator; AP-1; activator protein 1; APAF-1; apoptotic peptidase activat

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2017 سفارش ترجمه

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5α-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration

Keywords: SCI; Spinal cord injury; CNS; Central nervous system; PG; Progesterone; CTL; Control animals; HX; Injured animals; HX+PG; Injured animals that received daily injections of natural progesterone; PCR; Polymerase chain reaction; Cyc; Cyclophilin; TSPO; Trans

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation

Keywords: TSPO; Ro5-4864; NLRP3; Inflammasome; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo

Keywords: AD; Alzheimer's disease; GAMSA; GABAA receptor modulating steroid antagonists; EEG; electroencephalography; HE; hepatic encephalopathy; i.p.; intraperitoneal; i.v.; intravenous; LTP; long term potentiation; 17PA; (3α5α)-17-phenylandrost-16-en-3-ol; SE

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis

Keywords: TSPO; Translocator protein; PIGAs; N,N-dialkyl-2-phenylindol-3-ylglyoxylamides; BSO; l-buthionine-(S,R)-sulfoximine; AMG; aminoglutethimide; PBR; peripheral-type benzodiazepine receptor; StAR; steroidogenic acute regulatory protein; P450scc; P450 side cha

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [18F]FEDAC: Prerequisites for clinical application

Keywords: FEDAC; 18F; TSPO; PET; Extended single-dose toxicity study

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of Multiple Sclerosis

Keywords: neuroprotection; EAE; TSPO; agonist; neurosteroid; allopregnanolone; pharmacology; etifoxine; XBD-173; Darkagouti rat; MS; Multiple Sclerosis; EAE; experimental autoimmune encephalomyelitis; dpi; days post induction; div; days in vitro; po; per os; ip;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Investigation of the mechanisms of neuroprotection mediated by Ro5-4864 in brain injury

Keywords: CsA; cyclosporine A; GFAP; anti-glial fibrillary acidic protein; IL-1β; interleukin-1β; mPTP; mitochondrial permeability transition pore; ROI; regions of interests; TSPO; translocator protein; 18-kDa translocator protein; mitochondrial permeability tran

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

TSPO Finds NOX2 in Microglia for Redox Homeostasis

Keywords: TSPO; peripheral benzodiazepine receptor; NADPH oxidase (NOX2); redox homeostasis; microglia

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Translocator protein ligands based on N-methyl-(quinolin-4-yl)oxypropanamides with properties suitable for PET radioligand development

Keywords: Translocator protein; PET; Carbon-11; Ligand; Binding affinity; Lipophilic efficiency; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; DMSO; dimethylsulfoxide; HFIP; hexafluoroisopropyl alcohol; HRMS-ESI; high resolution mass spectrometry electr

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology

Keywords: Translocator protein 18 kDa; TSPO; Sandhoff disease; Biomarker; Microglia; Astrocytes; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

A bispecific antibody (ScBsAbAgn-2/TSPO) target for Ang-2 and TSPO resulted in therapeutic effects against glioblastomas

Keywords: Agn-2; TSPO; Targeted therapy; ScBsAbAgn-2/TSPO; Glioblastoma;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model

Keywords: Neurosteroid; Allopregnanolone; TSPO; 5α-reductase; Glaucoma; Neuroprotection

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction

Keywords: BPnd; non-displacable binding potential; CG; cingulate cortex; CP; caudate putamen; CT; computed tomography; Ctrl; control; Ctrl-PBO; placebo-treated control cohort; Ctrl-NAc; NAc-treated control cohort; FOV; field of view; GSH; glutathion; HC; hippocampu

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

Comparison of standardized uptake values with volume of distribution for quantitation of [11C]PBR28 brain uptake

Keywords: PET; PBR28; TSPO; SUV; Validity; Inflammation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Evolving understanding of translocator protein 18 kDa (TSPO)

Keywords: TSPO; translocator protein 18 kDa; PBR; peripheral-type benzodiazepine receptor; RsTSPO; TSPO from Rhodobacter sphaeroides; BcTSPO; TSPO from Bacillus cereus; mTSPO; TSPO from mouse; MPTP; mitochondrial permeability transition pore; VDAC; voltage depende

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila

Keywords: Parkin; TSPO; Innate immune response; VDAC (porin); Septic injury; Wound

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA

Keywords: Arteriosclerosis; Macrophages; Coronary artery disease; TSPO imaging; oxLDL; iodoDPA; iodo-DPA-713; SPECT; single-photon emission tomography; TSPO; translocator protein; HFHC; high fat high cholesterol;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line

Keywords: 18-kDa translocator protein; TSPO; Imidazo[1,2-a]pyridine; Steroidogenesis; Leydig tumor cell line;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Combined effect of G3139 and TSPO ligands on Ca2+-induced permeability transition in rat brain mitochondria

Keywords: VDAC; TSPO; Mitochondria; Permeability transition pore; PK11195; G3139ANT, adenine nucleotide translocase; PK11195, 1-(2-Chlorophenyl-N-methylpropyl)-3-isoquinolinecarboxamide; PPIX, protoporphyrin IX; mPTP, mitochondrial permeability transition pore; RBM

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo imaging and characterization of [18F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET

Keywords: TSPO; PET; [18F]DPA-714; Biodistribution; Neuroinflammation; Microglia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis

Keywords: TSPO; Steroidogenesis; Pharmacology; Adrenal; Gonads; Brain

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective

Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Tumor mitochondria-targeted photodynamic therapy with a translocator protein (TSPO)-specific photosensitizer

Keywords: Photodynamic therapy; Photosensitizer; Translocator protein; TSPO; Mitochondria; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and anxiolytic-like activity of 1-arylpyrrolo[1,2-a]pyrazine-3-carboxamides

Keywords: Anxiolytic activity; Elevated plus maze test; Open field test; PK11195; Pyrrolo[1,2-a]pyrazines; TSPO; Vinyl azides;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis

Keywords: 3-D; three-dimensional; CA; cornu ammonis; CT; computed tomography; DG; dentate gyrus; DH; dentate hilus; GFAP; glial fibrillary acid protein; KA; kainic acid; KASE; kainic acid-induced status epilepticus; MR; magnetic resonance; MRI; magnetic resonance i

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[18F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer

Keywords: TSPO; Glioma; PET; Fluorine-18; SSR180575

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Cytotoxic effect of hemin in colonic epithelial cell line: Involvement of 18 kDa translocator protein (TSPO)

Keywords: Hemin; TSPO; HO-1; Cell proliferation; PK 11195; Sn-PPIX; si-RNA

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis of [11C]PBR170, a novel imidazopyridine, for imaging the translocator protein with PET

Keywords: Carbon-11; [11C]PBR170; TSPO; [11C]methyl iodide; PET;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43

Keywords: Carbenoxolone; Protoporphyrin IX; TSPO; Connexins; Mitochondria; Permeability transition pore;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18 kDa (TSPO) radioligand, [18F]-FEPPA

Keywords: Neuroinflammation; PET imaging; Microglia activation; TSPO; Healthy aging; [18F]-FEPPA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model

Keywords: Positron emission tomography; Translocator protein 18 kDa; (R)-[11C]PK11195; Neuroinflammation; Pharmacoresistance; Drug refractoriness; TSPO; translocator protein 18 kDa; PET; positron emission tomography; TLE; temporal lobe epilepsy; AED; antiepilepti

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Methylmercury-induced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides)

Keywords: 11-KT; 11-ketotestosterone; ABCB7; ATP-binding cassette sub-family B (MDR/TAP), member 7; AMACR; alpha-methylacyl-CoA racemase; AR; androgen receptor; BEST; Biomonitoring of Environmental Status and Trends; BRD4; bromodomain containing 4; CASP3; caspase 3

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Isolation and characterization of MdATG18a, a WD40-repeat AuTophaGy-related gene responsive to leaf senescence and abiotic stress in Malus

Keywords: ATG18; AuTophaGy-related gene 18; CRL4; cullin4-RING ubiquitin ligase complex; Cvt; cytoplasm-to-vacuole targeting; DWD; DNA-binding WD40 proteins; EF-1α; elongation factor 1 alpha gene; ER; endoplasmic reticulum; MV; methyl viologen; ORF; open reading f

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Early repeated administration of progesterone improves the recovery of neuropathic pain and modulates spinal 18 kDa-translocator protein (TSPO) expression

Keywords: Progesterone; TSPO; Neuropathic pain;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-Potential novel positron emitting tomography imaging agents

Keywords: TSPO; PBR; PET; Neuroinflammation; Synthesis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Imaging of carrageenan-induced local inflammation and adjuvant-induced systemic arthritis with [11C]PBR28 PET

Keywords: [11C]PBR28; TSPO; Systemic adjuvant arthritis; Carrageenan-induced inflammation macrophages, RAW 264.7 cells;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction

Keywords: p53; Mitochondria; Rotenone; Embryo; PK11195; TspO;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Control of hypercholesterolemia and atherosclerosis using the cholesterol recognition/interaction amino acid sequence of the translocator protein TSPO

Keywords: TSPO; Cholesterol; CRAC domain; LDL; Atheroma; Drug development;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Extramitochondrial OPA1 and adrenocortical function

Keywords: [Ca2+]m; mitochondrial Ca2+ concentration; AKAP; A-kinase anchoring protein; CaMKII; Ca2+/calmodulin-dependent kinase II; COX IV; cytochrome c oxidase IV; db-cAMP; dibutiryl-cAMP; emOPA1; extramitochondrial OPA1; HSL; hormone-sensitive lipase; IMM; inner

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis

Keywords: cAMP; cyclic AMP; ACAT; acyl-CoA cholesterol acyltransferase; ACSL4; acyl-CoA synthetase 4; ANT; adenine nucleotide transporter; BN-PAGE; blue native polyacrylamide gel electrophoresis; CPT; carnitine palmitoyltransferase; ER; endoplasmic reticulum; ETC;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Expression and roles of steroidogenic acute regulatory (StAR) protein in 'non-classical', extra-adrenal and extra-gonadal cells and tissues

Keywords: OMM; outer mitochondrial membrane; IMM; inner mitochondrial membranes; TSPO; translocator protein; VDAC; voltage dependent anion channel; CNS; central nervous system; SR-BI; class-B type-I scavenger receptor; PTII; type II pneumonocytes; CCHCR1; Coiled-Co

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

In vitro targeting and imaging the translocator protein TSPO 18-kDa through G(4)-PAMAM-FITC labeled dendrimer

Keywords: TSPO; PAMAM dendrimer; Subcellular targeting; Imaging; Subcellular fractionation; Confocal microscopy;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2013 سفارش ترجمه