The translocator protein (TSPO): A novel target for cancer chemotherapy
Keywords: Translocator protein; TSPO; Cancer; Apoptosis; Cell homoeostasis
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Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling
Keywords: Benzodiazepines; GABA-A receptor; TSPO; Mast cell; HMC-1 cells; Mast cell activation disease
Distribution physiologique cérébrale et corps entier du 18F-DPA-714 en TEP/TDM
Keywords: TEP/TDM; 18F-DPA-714; Neuroinflammation; TSPO; BiodistributionPET/CT; 18F-DPA-714; Neuroinflammation; TSPO; Biodistribution
Neurosteroids, stress and depression: Potential therapeutic opportunities
Keywords: 5α-DHP; 5α-dihydroprogesterone; 3α-HSD; 3α-hydroxysteroid dehydrogenase; 3α5β-PC; 3α,5β-20-oxo-pregnane-3-carboxylic acid; 17-PA; 3α5α-17-phenylandrost-16-en-3-ol; ANT; adenine nucleotide transporter; ACTH; adrenocorticotrophic hormone; alloP; a
[18F]GE-180: A novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO)
Keywords: TSPO; PBR; PET; Neuroinflammation; Radiosynthesis
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein-potential novel positron emitting tomography imaging agents
Keywords: TSPO; PBR; PET; Neuroinflammation; Synthesis;
Research ArticleTranslocator protein (18Â kDa), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease
Keywords: TSPO; translocator protein (18Â kDa); PET; positron emission tomography; CT; computerized tomography; AUC; areas under the time activity curves; MCD; methionine and choline-deficient; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohep
Structure-activity relationship (SAR) analysis of a family of steroids acutely controlling steroidogenesis
Keywords: 19-Atriol; 5-androsten-3b,17,19-triol; 22R-HC; 22R-hydroxycholesterol; cAMP; cyclic adenosine monophosphate; CRAC; cholesterol recognition/interaction amino acid consensus; CYP11A1; cytochrome P450 11A1; dbcAMP; dibutyryl cyclic adenosine monophosphate; M
Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation
Keywords: TSPO; PET; [18F]DPA-714; Biodistribution; Dosimetry; Neuroinflammation
Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
Keywords: TSPO; PET; Radioligand; Biomathematical modelling; Multiple binding affinities;
Mouse TSPO in a lipid environment interacting with a functionalized monolayer
Keywords: PK 11195; N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; TSPO; 18Â kDa translocator protein; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine; DOGS-NTA-Ni; 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentanyl)iminodiacetic acid)succ
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat
Keywords: FPI; fluid percussion injury; GAP43; growth-associated protein 43; Iba-1; ionized calcium binding adaptor molecule 1; MHC; major histocompatibility complex; qRT-PCR; quantitative real-time PCR; S1BF; somatosensory barrel field; TBI; traumatic brain injury
Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102
Keywords: PBR; TSPO; 18F; Radiation dose
Functional characterization of the human translocator protein (18Â kDa) gene promoter in human breast cancer cell lines
Keywords: HBC; human breast cancer; HMEC; human mammary epithelial cells; TSPO; translocator Protein (18Â kDa); ChIP; chromatin immunoprecipitation; TSA; Trichostatin A; AZA; 5-Azacytidine; Sp/KLF; Specificity Protein/Krüppel-like factor; TSPO; Breast cancer; Meta
The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide
Keywords: CsA; cyclosporin A; Cu(OP)2; copper-o-phenanthroline; Cys; cysteine; EGTA; [ethylenebis(oxoethylenenitrilo)] tetraacetic acid; FGIN1-27; N,N-dihexyl-2-(4-fluorophenyl)indole-3-acetamide; HP; hematoporphyrin IX; IMM; inner mitochondrial membrane; MOPS; 4-m
Localization and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney
Keywords: CYP11A1; cytochrome P450 side chain cleavage enzyme; CYP17; cytochrome P450 17α-hydroxylase/17,20 lyase/17,20 desmolase; GAPDH; glyceraldehyde phosphate dehydrogenase; 3β-HSD; 3β-hydroxysteroid dehydrogenase; 11β-HSD; 11β-hydroxysteroid dehydrogenase
Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AQP-4; aquaporin-4; ATP; adenosine triphosphate; Aβ; amyloid-β peptide; APP; amyloid precursor protein; BBB; blood-brain barrier; BCSFB; blood-cerebrospinal fluid barrier; CT; computed tom
The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo
Keywords: solasodine; neurogenesis; TSPO; neurosteroids; GAP43; subventricular zone; AD; Alzheimer's disease; ChAT; choline acetyltransferase; CNPase; 2â²,3â²-cyclic nucleotide 3â² phosphodiesterase; DCX; doublecortin; DMSO; dimethyl sulfoxide; GABA-A; gamma-ami
Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO)
Keywords: Peripheral-type benzodiazepine receptor; Translocator protein; TSPO; Steroidogenesis; Pyrazolo[1,5-a]pyrimidine; Neurodegeneration; Neuroprotection; Microglia
Evaluation of [11C]-DAA1106 for imaging and quantification of neuroinflammation in a rat model of herpes encephalitis
Keywords: Positron emission tomography; Neuroinflammation; Microglia; Herpes viruses; [11C]-DAA1106; [11C]-PK11195; TSPO
Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo
Keywords: TSPO; Ehrlich cell; Diazepam; Cancer; Benzodiazepine; Anxiety
In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC
Keywords: Small-animal PET; TSPO; Heart; Lung; Kidney; Pseudo-equilibrium method
Oral cancer, cigarette smoke and mitochondrial 18 kDa translocator protein (TSPO) — In vitro, in vivo, salivary analysis
Keywords: TSPO; Cigarette smoke; Oral cancer; Prognosis; Saliva
Effects of different doses and schedules of diazepam treatment on lymphocyte parameters in rats
Keywords: Diazepam; Lymphocytes; PBR; TSPO; Tolerance; Flow cytometry
Synthesis of [125I]iodoDPA-713: A new probe for imaging inflammation
Keywords: TSPO; translocator protein; [125I]iodoDPA-713; N,N-diethyl-2-[2-(3-[125I]iodo-4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]acetamide; PK11195; N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; SPECT; single photon emission
Olesoxime (cholest-4-en-3-one, oxime): Analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel
Keywords: Chemotherapy; Mitochondria; Neuropathic pain; Neuroprotection; TSPO; VDAC;
Neuroprotective effects of a ligand of translocator protein-18kDa (Ro5-4864) in experimental diabetic neuropathy
Keywords: streptozotocin; neuroactive steroids; TSPO; rat; myelin proteins; peripheral nerveDHP, dihydroprogesterone; DHT, dihydrotestosterone; IENF, intra-epidermal nerve fiber; LC–MS/MS, liquid chromatography–tandem mass spectrometry; NCV, nerve conduction veloci
Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis
Keywords: Translocator protein 18 kDa; TSPO; Peripheral benzodiazepine receptor; Pain; Inflammation; Inflammatory pain; Arthritis; Spinal cord
Non-invasive visualization of CNS inflammation with nuclear and optical imaging
Keywords: neuroinflammation; PET; SPECT; optical imaging; bioluminescence; fluorescence; AD; Alzheimer's disease; BBB; blood-brain barrier; BLI; bioluminescence imaging; CCD; charge-coupled device; CNS; central nervous system; EAE; experimental autoimmune encepha
Novel channels of the inner mitochondrial membrane
Keywords: ANT; Adenine Nucleotide Translocator; BHT; 3,5-di-t-Butyl-4-HydroxyToluene; BKCa; Big Ca-dependent K+ channel; CaM; Calmodulin; CLIC; Chloride-selective Intracellular Channel; CSA; Cyclosporin A; diCl-DHAA; 12,14-dichlorodehydroabietic acid; ÎÏm; mitoch
Is there a mitochondrial signaling complex facilitating cholesterol import?
Keywords: Steroid biosynthesis; TSPO; PBR; StAR; AKAP; Adrenal; Gonads
Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands
Keywords: TSPO; Translocator protein (18 kDa); PBR; Cholesterol; Mitochondria; Lipid droplets; MTT; Acidic vesicles; Immunocytochemistry