Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism

▶ Thiamine deficiency (TD) models several aspects of neurodegenerative disease pathophysiology. ▶ Impaired oxidative metabolism plays a major role in the pathophysiology of TD and many neurodegenerative diseases. ▶ Consequences of TD include lactic acidosis, astrocyte dysfunction, oxidative stress, excitotoxicity, inflammation, blood-brain barrier dysfunction, amyloid deposition. ▶ Understanding the mechanisms underlying TD pathology can provide insight into how neurodegenerative disease states evolve, along with potential therapeutic strategies.