Keywords: توبولین; Molecular hybridization; Fusion; Cancer; Cytotoxic; Tubulin; Colchicine
مقالات ISI توبولین (ترجمه نشده)
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Keywords: توبولین; APM; amiprophos methyl; Phenoxyoxazaphospholidines; Phenoxyoxazaphosphinanes; Benzodioxaphosphininamines; Anti-malarial; Tubulin;
Keywords: توبولین; Inhibitor; Tubulin; Post-translational modification; Ligase; Phosphinic acid;
Keywords: توبولین; Depression; Cytoskeleton; Post-translational modification; Tubulin; Microtubule; Actin;
Keywords: توبولین; Phenstatin; Tubulin; Antimitotic agent; Fluorobenzophenone; Eaton's reagent;
Keywords: توبولین; Millepachine; Chalcone; Tubulin; Anticancer;
Keywords: توبولین; APM; amiprophosmethyl; BSA; bovine serum albumin; GFP; green fluorescent protein; MBP; Escherichia coli maltose-binding protein; MCAC; metal-chelate affinity chromatography; MT; microtubule; PIPES; 1,4-piperazinediethanesulphonic acid; SDS-PAGE; sodium do
Synthesis and evaluation of C2 functionalized analogs of the α-tubulin-binding natural product pironetin
Keywords: توبولین; Pironetin; Synthesis; Tubulin; Cytotoxicity; Structure-activity;
Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics
Keywords: توبولین; Triphala; Tubulin; Microtubules; Cancer; Natural products;
Activation of β- and α2-adrenergic receptors stimulate tubulin polymerization and promote the association of Gβγ with microtubules in cultured NIH3T3 cells
Keywords: توبولین; Microtubules; Gβγ; GPCR; Tubulin; Signal transduction;
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization
Keywords: توبولین; Microtubule; Cancer; Tubulin;
Starvation-, thermal- and heavy metal- associated expression of four small heat shock protein genes in Musca domestica
Keywords: توبولین; Cd; cadmium; Cr; chromium; EF1; elongation factor 1; H; high dose; L; low dose; MdomHSP; heat shock protein genes in Musca domestica; MEGA; molecular evolutionary genetics analysis; Pb; Lead; PCR; polymerase chain reaction; Rpl8; ribosomal large subunit 8
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents
Keywords: توبولین; Tubulin; Aminocombretastatin; Microtubules; Carbamates; Vascular disrupting agents; Apoptosis;
Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine
Keywords: توبولین; Anti-cancer; Colchicine; Combination index; Indirubin; Tubulin; Vinblastine;
Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance
Keywords: توبولین; Pt(IV) complex; Antitumor activity; Tubulin; Apoptosis;
Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors
Keywords: توبولین; Cancer; Shikonin; Twin drug; Pyruvate dehydrogenase kinase; Tubulin; CADD; computer assistant drug design; NOS; nitric oxide synthase; PKM2; pyruvate kinase isozymes M2; GLUT1; Glucose transporter 1; LA; alpha-lipoic acid; PDH; pyruvate dehydrogenase; PDC
Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design
Keywords: توبولین; Crystal structure; Tubulin; Colchicine binding site; Anthracenone; Drug design; CBSIs; colchicine binding site inhibitors; TPI1; tubulin polymerization inhibitor I; T2R; αβ-tubulin and the stathmin-like protein RB3; TTL; tubulin tyrosine ligase;
Photoresponsive azo-combretastatin A-4 analogues
Keywords: توبولین; Azobenzene; Photopharmacology; Tubulin; Combretastatin; Colchicine;
Tubulin posttranslational modifications in in vitro matured prepubertal and adult ovine oocytes
Keywords: توبولین; Tubulin; Ovine oocytes; Prepubertal; Posttranslational modifications; IVM;
Effects on tubulin polymerization and down-regulation of c-Myc, hTERT and VEGF genes by colchicine haloacetyl and haloaroyl derivatives
Keywords: توبولین; Tubulin; Colchicine; Microtubules; Polymerization; Cell cycle; c-Myc; hTERT; VEGF; Oncogene;
Design, synthesis and biological evaluation of a novel library of antimitotic C2-aroyl/arylimino tryptamine derivatives that are also potent inhibitors of indoleamine-2, 3-dioxygenase (IDO)
Keywords: توبولین; Tubulin; C2-aroyl/arylimino tryptamine; Antimitotic; Indoleamine-2; 3 dioxygenase;
Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity
Keywords: توبولین; Tubulin; Chalcones; Antiproliferative activity; Molecular modeling; CA1; combretastatin A1; CA2; combretastatin A2; CA4; combretastatin A4; CA4P; combretastatin A4 phosphate; R-PT; (R)-(+)-ethyl 5-amino 2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors
Keywords: توبولین; Microtubule; Tubulin; Cancer cell; Inhibitor; Indole; KQQGICRFCFANOA-UHFFFAOYSA-N; KWNHUNPLKHFGAK-UHFFFAOYSA-N;
Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs
Keywords: توبولین; Microtubules; Phenylpyrroloquinolinone; Tubulin; Apoptosis; Molecular docking; Structure-activity relationships;
1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity
Keywords: توبولین; Indole-3-glyoxamide derivatives; 1,2,3-triazoles; COX-1; COX-2; 5-LOX; Tubulin; Anti-proliferation;
Synthesis, cytotoxic evaluation and target identification of thieno[2,3-d]pyrimidine derivatives with a dithiocarbamate side chain at C2 position
Keywords: توبولین; Thieno[2,3-d]pyrimidine; Dithiocarbamate; Cytotoxicity; Probe; Target identification; Tubulin; Boc; tert-butyloxycarbonyl; CPT; camptothecin; DMF; N,N-dimethylformamide; DMSO; dimethyl sulphoxide; DSB; DNA double-strand break; EDCI; 1-ethyl-3-(3-dimethyla
Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20â² ethyl substituent
Keywords: توبولین; Vinblastine; Tubulin; Antitumor drug;
Data on the effect of hypomyelinating leukodystrophy 6 (HLD6)-associated mutations on the TUBB4A properties
Keywords: توبولین; HLD6; TUBB4A; Tubulin; Disease-associated mutation; Biochemical property;
Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation
Keywords: توبولین; MRP1; ABCC1; Protein interactions; Tubulin; Linker 1 domain; Phosphorylation;
Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin
Keywords: توبولین; Photoaffinity probe; Protein-protein interaction; Antitumor natural products; Actin; Tubulin;
Tubulins and brain development - The origins of functional specification
Keywords: توبولین; Microtubules; tubulin; neurogenesis; neuronal migration; neuronal differentiation;
Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren
Keywords: توبولین; Soil-transmitted helminth; Benzimidazole; Albendazole; Resistance; Ascaris; Deworming; Tubulin;
Enhanced anticancer effect of Combretastatin A-4 phosphate when combined with vincristine in the treatment of hepatocellular carcinoma
Keywords: توبولین; Combretastatin; Hepatic cancer; Tubulin; Vincristine; Vascular disrupting agents;
Original contributionβIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer
Keywords: توبولین; TUBB3; Tubulin; Bladder cancer; Immunochemistry; Prognosis;
Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors
Keywords: توبولین; Cancer; Quinoline; isoCA-4; Cytotoxicity; Tubulin; Binding;
Synthesis, biological evaluation and molecular modeling of imidazo[1,2-a]pyridine derivatives as potent antitubulin agents
Keywords: توبولین; Imidazo[1,2-a]pyridines; Tubulin; Synthesis; Cytotoxicity; Molecular modeling;
Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon
Keywords: توبولین; Brain; Schizophrenia; Endocytosis; Lysosome; Clathrin; Adaptor protein; AP-1; AP-2; AP-3; Tubulin;
Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein
Keywords: توبولین; Virtual screening; Docking; Tubulin; P-gp;
Identification of potent virtual leads and ADME prediction of isoxazolidine podophyllotoxin derivatives as topoisomerase II and tubulin inhibitors
Keywords: توبولین; Podophyllotoxin; Molecular docking; Topoisomerase; Tubulin; ADMET;
Genome-wide mRNA analysis reveals a TUBD1 isoform profile as a potential biomarker for diabetic retinopathy development
Keywords: توبولین; Diabetic retinopathy; RNA expression; Alternative splicing; Whole transcriptome analysis; Tubulin; Delta-1;
Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents
Keywords: توبولین; Antiproliferative; Anticancer; Combretastatin A-4; Microtubule-destabilising; Piperlongumine; Tubulin;
Growth arrest and morphological changes triggered by emodin on Trypanosoma cruzi epimastigotes cultivated in axenic medium
Keywords: توبولین; Trypanosoma cruzi epimastigotes; Emodin; Cytoskeleton; Protein kinase CK2; Tubulin; Cytokinesis; Chagas disease; 2,3-BPG; 2,3-bisphosphoglycerate; DRB; 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole; KN-62; 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-ty
Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues
Keywords: توبولین; Combretastatin A4; Antiproliferation; 1,2,4-Triazole; Tubulin; Molecular docking;
Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents
Keywords: توبولین; Microtubules; Phenylpyrroloquinolinone; Tubulin; Apoptosis; Molecular docking; Structure-activity relationships; OHSPNEMFDWDQMK-UHFFFAOYSA-N;
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates
Keywords: توبولین; Metathesis; Histone deacetylases; Cancer; Tubulin
Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance
Keywords: توبولین; Surface plasmon resonance; Protein-protein interaction; Antitumor natural products; Actin; Tubulin;
In vitro screening of BTP-Iso on Schistosoma mansoni and its intermediate host Biomphalaria alexandrina
Keywords: توبولین; Schistosoma mansoni; Benzimidazoles; Tubulin; Tegument; In vitro; Snail;
Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents
Keywords: توبولین; EDG, electron donating group; EWG, electron withdrawing groups; MT, microtubule; SAR, structure activity relationshipHexahydropyrazole; Anti-mitotic; Tubulin; Docking; Tubulin binding assay; Colchicine-binding assay
Enhanced dynamic instability of microtubules in a ROS free inert environment
Keywords: توبولین; Microtubule; Tubulin; Dynamic instability; Total internal reflection fluorescence microscopy; Reactive oxygen species; Oxidative stress;
Indomethacin derivatives as tubulin stabilizers to inhibit cancer cell proliferation
Keywords: توبولین; COX, cyclooxygenase; NSAIDs, non-steroidal anti-inflammatory drugs; SAR, structure activity relationship; DCC, N,N′-dicyclohexylcarbodiimide; PyBOP, benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphateCOX inhibitor; Indomethacin; Tubulin; Ca