Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues
Keywords: توبولین; Combretastatin; Phenstatin; Aroylindole; Tubulin; Cytotoxicity;
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Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization
Keywords: توبولین; Tubulin; Colchicine; Arylthioindole; Docking; Molecular dynamics
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole
Keywords: توبولین; Anti-cancer agent; Diketopiperazine; Phenylahistin; Tubulin; Vascular disrupting agent;
Effect of chitosan malate on viability and cytoskeletal structures morphology of Caco-2 cells
Keywords: توبولین; Chitosan malate; Caco-2 cells; Cytotoxicity; Cell cytoskeleton; Tubulin; Actin
First molecular evidence of diatom effects in the copepod Calanus helgolandicus
Keywords: توبولین; Copepod; Diatom; PUA; Reference genes; RT-qPCR; Tubulin
H89 sensitive kinase regulates the translocation of Sar1 onto the ER membrane through phosphorylation of ER-coupled β-tubulin
Keywords: توبولین; ER-to-Golgi transport; Tubulin; Protein phosphorylation; Sar1; Coat assembly;
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
Keywords: توبولین; Tubulin; Tubulin-active compound; Microtubule; Microtubule destabilization; Pironetin analogue; Cytotoxicity
Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin
Keywords: توبولین; Discodermolide; Tubulin; Synthesis; Fluorescence;
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization
Keywords: توبولین; Phenylimino-10H-anthracen-9-ones; 9-(Phenylhydrazone)-9,10-anthracenediones; Tubulin; Antiproliferative; Antimitotic; Colchicine; ADR; adriamycine; ITP; inhibition of tubulin polymerization; Kip; Kinase inhibitor protein; MDR; multi-drug resistant; MTP; m
The ins and outs of tubulin acetylation: More than just a post-translational modification?
Keywords: توبولین; Acetylation; Tubulin; Microtubule; HDAC6; Signalling; Post-translational modification;
Acetyl analogs of combretastatin A-4: Synthesis and biological studies
Keywords: توبولین; Combretastatin A-4; Trimethoxyphenylacetone; Tubulin; Microtubule; Cytotoxicity; Cancer
One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent
Keywords: توبولین; Microtubules; Structure-activity relationship; Thiazole; In vivo and in vitro activity; Tubulin
A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain
Keywords: توبولین; LA; (±)-α-lipoic acid; EMSA; electrophoretic mobility-shift assay; FBS; fetal bovine serum; GD; gestation day; hRNP; heterogeneous nuclear ribonucleoprotein; MZ; marginal zinc; NAC; N-acetylcysteine; TCEP; tris(2-carboxyethyl)phosphine; Zinc; Brain; Red
Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
Keywords: توبولین; Calycopterin; Calycopteris floribunda; Flavones; Antiproliferative activity; Antimitotic; Tubulin; Combretastatins;
What tubulin drugs tell us about microtubule structure and dynamics
Keywords: توبولین; Tubulin; FtsZ; Taxol; Vinblastine; Dynamic instability;
Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices
Keywords: توبولین; Cytoplasmic lattice; PADI6; Tubulin; Acetylated microtubule; Spindle; Organelle redistribution; Endoplasmic reticulum; Mitochondria; Oocyte maturation;
Synthesis and biological evaluation of phenstatin metabolites
Keywords: توبولین; Anticancer agent; Tubulin; Phenstatin; Metabolite; Murine leukemia; Friedel–Crafts acylation; Eaton’s reagent
Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation
Keywords: توبولین; UTFCQQAIHHBQRA-MISQFGSZSA-N; RMNBCQONWRRLRH-DBZGNIOYSA-N; DIFJYAJUVYFOAA-SWQNAEFKSA-N; FOCMUWGDUIERRP-YREBQOROSA-N; RXCWJGYKZBVKPD-GGHUVPMOSA-N; APQNUDLGDPTPLT-VASYMWTCSA-N; RHUFDRUJAUOZAP-UJKOFHHOSA-N; FXHOZWWSCCJRPU-GOPAMZTCSA-N; Simplified paclitaxel;
3-Aryl-2-[1H-benzotriazol-1-yl]acrylonitriles: A novel class of potent tubulin inhibitors
Keywords: توبولین; 3-Aryl-2-[1H-benzotriazol-1-yl]acrylonitriles; Antiproliferative activity; Tubulin; Homology studies; Molecular modeling study; Cell cycle distribution; Podophyllotoxin; Colchicine
The Fc receptor-cytoskeleton complex from human neutrophils
Keywords: توبولین; AEBSF; 4-(2-Aminoethyl) benzenesulfonyl fluoride; CID; Collision-induced dissociation; Da; Dalton; ESI; electro spray ionization; GAP; GTPase activating protein; GEF; guanine exchange factor; HPMI; HEPES Park Memorial Institute; LARC; live-cell affinity r
Discovery of a potent tubulin polymerization inhibitor: Synthesis and evaluation of water-soluble prodrugs of benzophenone analog
Keywords: توبولین; Tubulin; Inhibitor; Prodrug; Aqueous solubility; Antitumor activity
Synthesis and evaluation of oryzalin analogs against Toxoplasmagondii
Keywords: توبولین; Toxoplasma; Tubulin; Oryzalin; Trifluralin; Dinitroaniline
Recovery of tubulin functions after freeze-drying in the presence of trehalose
Keywords: توبولین; Cytoskeleton; Tubulin; Stability; Freeze-drying; Bionanodevices
Anti-microtubule ‘plinabulin’ chemical probe KPU-244-B3 labeled both α- and β-tubulin
Keywords: توبولین; Anti-cancer agent; Diketopiperazine; Phenylahistin; Tubulin; Vascular disrupting agent
Regulation of cellular actin architecture by S100A10
Keywords: توبولین; Cytoskeleton architecture; S100A10; Actin; Tubulin; Annexin A2; Migration;
TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase
Keywords: توبولین; TPCK; Tubulin; Cell division; Apoptosis
The role of βIII tubulin in predicting chemoresistance in non-small cell lung cancer
Keywords: توبولین; Non-small cell lung cancer; Biomarker; Tubulin; ERCC1; RRM1; Tubulin-binding agent; Taxane; Epothilone;
Heterogeneous and homogeneous nucleation of Taxol™ crystals in aqueous solutions and gels: Effect of tubulin proteins
Keywords: توبولین; Taxol; Paclitaxel; Crystals; Spherulites; Tubulin; Nucleation; Microtubule aster
A conditioning lesion induces changes in gene expression and axonal transport that enhance regeneration by increasing the intrinsic growth state of axons
Keywords: توبولین; Axon regeneration; Conditioning lesion; Axonal transport; Slow component a (SCa); Slow component b (SCb); Tubulin; Gene expression; Intrinsic growth state; Dorsal root ganglion neuron; Retinal ganglion cell neuron; Neurofilament protein; Peripheral nerve
SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology
Keywords: توبولین; Sirtuin; SIRT2; Deacetylation; Oligodendrocyte; Brain; Neuron; Neurite; Growth cone; Cytoskeleton; Tubulin
Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death
Keywords: توبولین; Polyglutamine; Ubiquitin-proteasome; Sinocerebellar ataxia type 3; Tubulin;
Taxol-induced polyploidy and cell death in CHO AA8 cells
Keywords: توبولین; Apoptosis; CHO AA8 cells; Mitotic catastrophe; Taxol; Tubulin
Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
Keywords: توبولین; Phenstatin; Indole; Tubulin; Combretastatin; Cytotoxicity; Antitumour; Oxime; Hydrazone; Hydrazide; Acetylderivatives; 2,3,4-Trimethoxyphenyl
Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives
Keywords: توبولین; Antitumor activity; Cytotoxicity; Dihydropyrazole; Tubulin
Total synthesis of (â)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin
Keywords: توبولین; Macrolide; Cytotoxic; Tubulin; Aldol reaction; Olefination;
Cognitive, Behavioral, and Systems NeuroscienceResearch PaperChanges in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice
Keywords: توبولین; cytoskeletal plasticity; stable isotope labeling; biomarker; spine density; tubulin; NMDA receptors; 2H; two atoms of hydrogen; 2H2O; heavy water; AMPA; α-amino-5-hydroxy-3-methyl-4-isoxazole propionic acid; AP5; D-(-)-2-amino-5-phosphonopentanoic acid
Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel
Keywords: توبولین; Paclitaxel-mimics; Anticancer; Cytotoxicity; Alkaloid; Molecular-modeling; REDORE-Taxol; Tubulin
Increased cellular apoptosis susceptibility (CSE1L/CAS) protein expression promotes protrusion extension and enhances migration of MCF-7 breast cancer cells
Keywords: توبولین; Cancer; Microtubules; Migration; Protrusion; Tubulin; Tyrosine phosphorylation;
Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies
Keywords: توبولین; Combretastatin CA-4 derivatives; Cytotoxicity; Tubulin; Molecular modeling;
Structure–activity relationships of indole compounds derived from combretastatin A4: Synthesis and biological screening of 5-phenylpyrrolo[3,4-a]carbazole-1,3-diones as potential antivascular agents
Keywords: توبولین; Antitumor agents; Endothelial cells; Multicomponent reactions; Tubulin; Vascular-disrupting agents
Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation
Keywords: توبولین; Zebrafish; Myelination; Tubulin; Oligodendrocyte; Schwann cell; Post-embryonic development; Craniofacial skeleton; Pigment pattern
Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish
Keywords: توبولین; Retina; Retinal ganglion cell; Tubulin; KLF; Optic nerve; p27; Promoter
Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects
Keywords: توبولین; Combretastatin A-4 analogues; β-Lactam; 2-Azetidinone; Cytotoxicity; Tubulin; Structure–activity
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays
Keywords: توبولین; anti-mitotic agent; 1,3,4-Oxadiazoles; Combretastatin; Tubulin; Microtubules; Sea urchin embryo; Cancer
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety
Keywords: توبولین; Benzylidene-10H-anthracen-9-ones; 10-(2-Oxo-2-phenylethylidene)-10H-anthracen-9-ones; Tubulin; Antiproliferative; Antimitotic; ColchicineADR, adriamycine; CSI, colchicine site inhibitor; DBU, 1,8-Diazabicyclo[5.4.0]undec-7-ene; ITP, inhibition of tubulin
Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome
Keywords: توبولین; Permeabilized cell; Respiration; Mitochondria; Creatine kinase; Tubulin; Systems biology; Energy metabolism;
Synthesis and SAR of C12–C13-oxazoline derivatives of epothilone A
Keywords: توبولین; Epothilone; Natural product; Tubulin; Anticancer; SAR
Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation
Keywords: توبولین; Taxol; Paclitaxel; Tubulin; Antiproliferative activity; T-Taxol; Conformation; Synthesis
Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents
Keywords: توبولین; Hexahydroquinoline; Trimethoxyphenyl; Anticancer; Tubulin;
Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity
Keywords: توبولین; HDAC6; p300; Acetylation; Tubulin; Sp1;