Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices

► Alpha tubulin is associated with PADI6 at the oocyte cytoplasmic lattices. ► PADI6 and the oocyte lattices play a critical role in the redistribution of mitochondria and endoplasmic reticulum during oocyte maturation. ► Organelles are diffusely distributed in PADI6-null oocytes and appear to be dissociated from microtubules. ► PADI6-null oocytes appear to lack stable acetylated cytoplasmic microtubules.