p53: The barrier to cancer stem cell formation
Keywords: تومورزایی; Stem cells; p53; Loss of heterozygosity; Cancer stem cells; Tumorigenesis;
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Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells
Keywords: تومورزایی; Phosphatase 2A; PPP2R5E; miR-23a; Gastric cancer; Tumorigenesis; Apoptosis;
The two faces of IL-6 in the tumor microenvironment
Keywords: تومورزایی; IL-6 trans-signaling; Tumorigenesis; T cell trafficking; Adaptive tumor immunity
Bioengineering 3D environments for cancer models
Keywords: تومورزایی; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; 2D; two-dimensional; 3D; three-dimensional; PEG; polyethylene glycol; PLG; poly(lactide-co-glycolide); PLA; polylactic acid; RGD; arginine-glycine-aspartate peptide sequence; MMPs; m
Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response
Keywords: تومورزایی; Prostate cancer stem cell; Cell proliferation; Cell signaling; DNA damage response; Tumorigenesis
cAMP signalling in the normal and tumorigenic pituitary gland
Keywords: تومورزایی; cAMP; Secondary signalling; Pituitary hormones; Tumorigenesis; Adenoma;
Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells
Keywords: تومورزایی; Nicotinamide N-methyltransferase; Colorectal cancer; Cell cycle; Apoptosis; 1-Methylnicotinamide; Tumorigenesis;
Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells
Keywords: تومورزایی; ChIP; chromatin immunoprecipitation; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GO; gene ontology; H3K27me3; histone 3 lysine 27 trimethyl; HNSCC; head and neck squamous cell carcinoma; HOX; homeobox; HPRT1; hypoxanthine phosphoribosyltransferase 1;
mTOR signaling in tumorigenesis
Keywords: تومورزایی; mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis
Keywords: تومورزایی; APC/C; Anaphase Promoting Complex/Cyclosome; AOM; azoxymethane; Bub3; budding uninhibited by benzimidazole protein 3; BubR1; bub1-related protein; Cdc20; cell division cycle 20; Cdh1; Cdc20 homologue protein 1; DMBA; 7,12-dimethylbenz-α-anthracene; Emi1;
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
Keywords: تومورزایی; STAT3; Inhibitors; Tumorigenesis; Inflammation; Proliferation; Metastasis;
Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice
Keywords: تومورزایی; Cancer Stem Cell; H4C4; Tumorigenesis; Progression; EMT; epithelial-mesenchymal transition; mRNA; messenger RNA; nIgG; normal mouse IgG; STAT3; signal transducer and activator of transcription 3; TIC; tumor-initiating cell;
MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression
Keywords: تومورزایی; Pancreatic Cancer; miRNAâmRNA Interaction; Tumorigenesis; Oncogene; anti-miR; antisense miRNA inhibitor; miRNA; microRNA; mRNA; messenger RNA; NC; negative control; OS; overall survival; PDAC; pancreatic ductal adenocarcinoma; pre-miR; precursor miRNA;
miR-128 and its target genes in tumorigenesis and metastasis
Keywords: تومورزایی; MicroRNA-128 (miR-128); Target genes; Tumorigenesis; Metastasis;
In vitro cytokine expression in in situ-like areas of malignant neoplasia
Keywords: تومورزایی; Neoplasia; Interleukins; Pleomorphic adenoma; Tumorigenesis;
Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation
Keywords: تومورزایی; Kinesin-8 Kif18a; Tumorigenesis; Colitis-associated cancer; Knock-out mice; AOM-DSS model; Akt;
CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo
Keywords: تومورزایی; CIZ1 (Cip1 interacting zinc finger protein 1); p21Cip1/Waf1; Cell proliferation; Tumorigenesis;
Hyper-methylated miR-203 dysregulates ABL1 and contributes to the nickel-induced tumorigenesis
Keywords: تومورزایی; NSTCs; Ni3S2-transformed 16HBE cells; Nickel; Tumorigenesis; miR-203; Hypermethylation; ABL1;
Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila
Keywords: تومورزایی; Integrin; Intestinal stem cell; Niche; Maintenance; Proliferation; Basement membrane; Drosophila; Tumorigenesis;
miRNAs regulate expression and function of extracellular matrix molecules
Keywords: تومورزایی; miRNA; microRNA; ECM; extracellular matrix; mRNA; messenger RNA; MMP; matrix metalloproteinase; TIMP; tissue inhibitor of metalloproteinases; ncRNA; non-coding RNAs; lncRNA; long non-coding RNA; 3â²UTR; 3â²-untranslated region; Col-1; collagen type I; H
Original ResearchFull Report: Basic and Translational-PancreasGenetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor
Keywords: تومورزایی; Pancreas; Tumorigenesis; LCM; Whole-Genome Amplification; AAF; alternate allele frequency; ATM; ataxia telangiectasia mutated; LCM; laser capture microdissection; P; pancreatic intraepithelial neoplasia alone; PanIN; pancreatic intraepithelial neoplasia;
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression
Keywords: تومورزایی; Adenomatous polyposis coli (APC); Wnt; Ras; Tumorigenesis; DE-cadherin; Drosophila;
Perivascular stem cell niche in head and neck cancer
Keywords: تومورزایی; Tumorigenesis; Angiogenesis; Stemness; Oral cancer; Tumor initiation; Tumor microenvironment
Natural products for cancer prevention associated with Nrf2–ARE pathway
Keywords: تومورزایی; Natural products; Cancer prevention; Nrf2–ARE pathway; Tumorigenesis; Dietary phytochemicals
Why is autophagy important for melanoma? Molecular mechanisms and therapeutic implications
Keywords: تومورزایی; Autophagy, Melanoma; Tumorigenesis; BRAF; Chemoresistance
Activation of the unfolded protein response bypasses trastuzumab-mediated inhibition of the PI-3K pathway
Keywords: تومورزایی; ER stress; Lipocalin 2; Tumorigenesis
Tumor suppressor BLU promotes paclitaxel antitumor activity by inducing apoptosis through the down-regulation of Bcl-2 expression in tumorigenesis
Keywords: تومورزایی; BLU tumor suppressor; Cell cycle progression; Chemotherapeutic drug; Bcl-2 regulator; Tumorigenesis
CD95 in cancer: tool or target?
Keywords: تومورزایی; CD95; FAS; apoptosis; tumorigenesis; clinical studies; cancer therapy
Targeting protein–protein interactions as an anticancer strategy
Keywords: تومورزایی; protein–protein interaction; cancer genomics; signaling network; high-throughput screening; small-molecule modulator; tumorigenesis
Small gastrointestinal stromal tumor in the stomach: identification of precursor for clinical gastrointestinal stromal tumor using c-kit and α-smooth muscle actin expression
Keywords: تومورزایی; Gastrointestinal stromal tumor; Small GIST; Stomach; KIT mutation; Tumorigenesis
Primary cutaneous carcinosarcoma: insights into its clonal origin and mutational pattern expression analysis through next-generation sequencing
Keywords: تومورزایی; Carcinosarcoma; Cutaneous; Biphenotypic tumors; Cancer stem cells; Tumorigenesis; Mutation; TP53; Next-generation sequencing
The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment
Keywords: تومورزایی; Nek6; Premature senescence; Cell cycle; ROS; Tumorigenesis
Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies
Keywords: تومورزایی; Brain tumor; Animal model; Tumorigenesis; Cancer therapy
Angiopoietins in angiogenesis
Keywords: تومورزایی; Angiogenesis; Angiopoietins; Pericytes; Tie receptors; Tumorigenesis; VEGFA
c-MYC overexpression overrides TAK1 dependency in efficient tumorigenicity of AKT-transformed cells
Keywords: تومورزایی; TAK1; AKT; Tumorigenesis; Transformation; c-Myc
Wnt signaling pathway is activated in right colon serrated polyps correlating to specific molecular form of β-catenin
Keywords: تومورزایی; β-Catenin; Hyperplastic polyp; Sessile serrated adenoma; Tumorigenesis; Wnt signaling
Missing the target: matrix metalloproteinase antitargets in inflammation and cancer
Keywords: تومورزایی; degradomics; proteomics; tumorigenesis; angiogenesis
BLU enhances the effects of anti-angiogenic activity in combination with gemcitabine-based chemotherapeutic agents
Keywords: تومورزایی; Tumor suppressor BLU gene; Gemcitabine traditional chemotherapeutic agent; Cell cycle arrest; VEGF receptor-2; Angiogenesis; Tumorigenesis;
Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer
Keywords: تومورزایی; hMOF; H4K16 acetylation; Skp2; Cell cycle; Tumorigenesis
Model animals for the study of oxidative stress from complex II
Keywords: تومورزایی; SDHC; Aging; Tumorigenesis; Apoptosis; Oxidative stress; Reactive oxygen species
Acute virulent infection with feline immunodeficiency virus (FIV) results in lymphomagenesis via an indirect mechanism
Keywords: تومورزایی; Feline immunodeficiency virus; FIV; Neoplasia; Lymphoma; Tumorigenesis; Lymphomagenesis
Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection
Keywords: تومورزایی; cyclooxygenase-2; tumorigenesis; innate immunity; epilepsy; neurotoxicity; neuroinflammation
THE ROLE OF MITOCHONDRIA IN THE DEVELOPMENT AND PROGRESSION OF LUNG CANCER
Keywords: تومورزایی; apoptosis; non-small cell lung cancer; mitochondrial dynamics; mitochondrial dysfunction; tumorigenesis
Autophagy regulation and its role in cancer
Keywords: تومورزایی; Macroautophagy; Tumorigenesis; Signaling pathways; Tumor suppression; Oncogenes
An Unusual Presentation of MEN-1
Keywords: تومورزایی; MEN-1; Menin; Carcinoid; Leiomyoma; Foregut; Gastrinoma; Tumorigenesis; Sestamibi scanning;
Ubiquitination and deubiquitination of REST and its roles in cancers
Keywords: تومورزایی; REST; Ubiquitination; Deubiquitination; Neural stem cell; Tumorigenesis;
Melanocytic tumor with GNA11 p.Q209L mutation mimicking a foramen magnum meningioma
Keywords: تومورزایی; Melanocytic tumor; Central nervous system; Intermediate grade; GNA11 p.Q209L mutation; Tumorigenesis;
miRNA-101: A potential target for tumor therapy
Keywords: تومورزایی; miRNA-101; Biogenesis; Target; Epigenetic regulation; Tumorigenesis; Gene therapy
Molecular basis of polycythemic disorders due to aberrant hypoxia sensing and its relevance to acute leukemia
Keywords: تومورزایی; acute leukemia forum; Beutler; cancer cell metabolism; glycolysis; hypoxia-inducible factor; HIF; HIF-1; HIF-2; HIF-3; IDH1; IDH2; isocitrate dehydrogenase; leukemia; polycythemia; tumorigenesis; von Hippel-Lindau; Warburg
How do tumor stem cells actively escape from host immunosurveillance?
Keywords: تومورزایی; Tumor stem cells; Immune escape; Microenvironment; Tumorigenesis