Erbin loss promotes cancer cell proliferation through feedback activation of Akt-Skp2-p27 signaling
Keywords: تومورزایی; Erbin; Akt; Skp2; p27; Cell proliferation; Tumorigenesis;
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PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma
Keywords: تومورزایی; Thyroid carcinoma; Tumorigenesis; Therapy resistance; PI3K; Akt; mTOR;
UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation
Keywords: تومورزایی; Tumorigenesis; UNC45A; Hsp90; Chaperone; ChK1; Centrosome;
Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride
Keywords: تومورزایی; 5αP; 5α-dihydroprogesterone; ELISA; enzyme-linked immunosorbent assay; ER; estrogen receptor; MAPK; mitogen-activated protein kinase; MPA; medroxyprogesterone acetate; P; progesterone; PR; progesterone receptor; RIA; radioimmunoassay; Breast cancer inhi
Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice
Keywords: تومورزایی; Capsaicin; DMBA/TPA; Skin inflammation; Tumorigenesis; COX-2; iNOS;
Pleiotropic roles in cancer biology for multifaceted proteins FKBPs
Keywords: تومورزایی; FK506 binding protein; Peptidyl-prolyl-isomerase; Tumorigenesis; Cancer;
CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells
Keywords: تومورزایی; Apoptosis; Ubiquitination; Signaling transduction; Tumorigenesis; Membrane protein;
Unpeaceful roles of mutant PAX proteins in cancer
Keywords: تومورزایی; PAX proteins; Chromosomal translocation; Tumorigenesis; Alveolar rhabdomyosarcoma; Precursor B-cell acute lymphoblastic leukemia;
Long noncoding RNAs: Novel players in colorectal cancer
Keywords: تومورزایی; Long noncoding RNAs; Colorectal cancer (CRC); Tumorigenesis; Therapeutic targets
ADAMTS proteases and cancer
Keywords: تومورزایی; Disintegrin; Metalloprotease; Thrombospondin; Tumorigenesis; Tumor microenvironment
The translation factor eIF5A and human cancer
Keywords: تومورزایی; Protein synthesis; Tumorigenesis; Eukaryotic initiation factor eIF5A; Hypusine modification; Translational control; Cancer therapeutics;
Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas
Keywords: تومورزایی; A; adenine; ASPS; alveolar soft part sarcoma; ASS1; argininosuccinate synthetase 1; BMP2; bone morphogenetic protein 2; C; cytosine; Da; Dalton; DFSP; dermatofibrosarcoma protuberan; DNA; deoxyribonucleic acid; EDTA; ethylenediaminetetraacetic acid; ES/pP
NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth
Keywords: تومورزایی; mTOR; Glut3; NFκB; Aerobic glycolysis; Tumorigenesis;
The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development
Keywords: تومورزایی; Sulfiredoxin; Peroxiredoxin; Redox signaling; Tumorigenesis; Oncogene;
MicroRNA-144 suppresses tumorigenesis and tumor progression of astrocytoma by targeting EZH2
Keywords: تومورزایی; Astrocytoma; MicroRNA-144; Enhancer of zeste homolog 2; Tumorigenesis; Clinicopathological feature; Prognosis
Long noncoding RNAs: Novel insights into gastric cancer
Keywords: تومورزایی; ABHD11-AS1; antisense RNA 1; ANRIL; CDKN2B antisense RNA 1; EMT; epithelial-mesenchymal transition; FER1L4; Fer-1-like protein 4; GACAT1; gastric cancer-associated transcript 1; GC; gastric cancer; HOTAIR; HOX transcript antisense RNA; LncRNA; long non-
MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications
Keywords: تومورزایی; miR-218; Target genes; Tumorigenesis; Metastasis;
Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice
Keywords: تومورزایی; CRC; colorectal cancer; APC; adenomatous polyposis coli; KBS; Kaiso binding site; CAC; colitis-associated cancer; IBD; inflammatory bowel disease; Kaiso; Apc; Wnt; Tumorigenesis; Inflammation;
Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment
Keywords: تومورزایی; mRNA translation; Translation initiation factor eIF2; Protein phosphorylation; Cell proliferation; Tumorigenesis; Chemotherapeutic drug;
OVA12, a novel tumor antigen, promotes cancer cell growth and inhibits 5-fluorouracil-induced apoptosis
Keywords: تومورزایی; OVA12; Tumor antigen; Tumorigenesis; 5-FU; Mcl-1; Survivin;
Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis
Keywords: تومورزایی; Nm23; NDPK; Ras; Neoplastic transformation; Tumorigenesis;
∆ DNMT3B4-del Contributes to Aberrant DNA Methylation Patterns in Lung Tumorigenesis
Keywords: تومورزایی; DNMT3B; ΔDNMT3B; ΔDNMT3B-del; DNA methylation; Lung cancer; Mouse model; Tumorigenesis
The role of PGE2 in intestinal inflammation and tumorigenesis
Keywords: تومورزایی; Prostaglandins; Colitis; Tumorigenesis; Microsomal prostaglandin E synthase-1; Cytosolic phosphlipase A2; Intestine
Functional and physiopathological implications of TRP channels
Keywords: تومورزایی; TRP channels; Cardiovascular disorders; Diabetes mellitus; Tumorigenesis; Cancer cells
BRCA1 regulates transforming growth factor-β (TGF-β1) signaling through Gadd45a by enhancing the protein stability of Smad4
Keywords: تومورزایی; BRCA1; Cell growth; Tumor suppressor gene; Gadd45a; TGF-β1; Ubiquitin; Tumorigenesis;
Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis
Keywords: تومورزایی; WWOX; WW domain-containing oxidoreductase; SUMO; small ubiquitin-like modifier; AP-1; activator protein-1; Pc2; polycomb2; SENP1; sentrin/SUMO-specific protease1; WW domain-containing oxidoreductase; Small ubiquitin-like modifier; Proliferation; Activator
Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance
Keywords: تومورزایی; Cancer; Insulin-like growth factor; Resistance; Therapy; Tumorigenesis
MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma
Keywords: تومورزایی; MicroRNA; Signaling pathway; Tumorigenesis; Pancreatic ductal adenocarcinoma
Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation
Keywords: تومورزایی; PKM2; DDB2; UV; Cell survival; Tumorigenesis;
FAK signaling in human cancer as a target for therapeutics
Keywords: تومورزایی; Tumorigenesis; Metastasis; Tyrosine kinase; Scaffold protein; Tyrosine kinase inhibitor; Cancer stem cellsATP, Adenosine triphosphate; CDK, cyclin-dependent kinase; JNK, c-jun N-terminal kinase; DRT, detergent-resistant membrane; EC, endothelial cell; EGF
MiR-21 promoted proliferation and migration in hepatocellular carcinoma through negative regulation of Navigator-3
Keywords: تومورزایی; Hepatocellular carcinoma; miR-21; Navigator-3; Migration; Tumorigenesis;
Original ResearchFull Report: Basic and Translational-Alimentary TractGenetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas
Keywords: تومورزایی; Colon Cancer; Hereditary Cancer; Genomic Instability; Tumorigenesis; BMP; bone morphogenetic protein; DSB; double-strand break; EVS; Exome Variant Server; ExAC; Exome Aggregation Consortium; FA; Fanconi's anemia; FCRC; familial colorectal cancer; HQV; h
Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice
Keywords: تومورزایی; NSAIDs; Cyclooxygenase; Colon Cancer; Tumorigenesis; CRC; colorectal cancer; CSC; cancer stem cells; Akt; protein kinase B; EP; prostaglandin E2 receptors; EpCAM; epithelial cellular adhesion molecule; ERK1; extracellular signal-regulated kinase 1; IHC;
Piwi-like 1 and 4 gene transcript levels are associated with clinicopathological parameters in renal cell carcinomas
Keywords: تومورزایی; Piwil; Piwi-like; ccRCC; Clear cell renal cell carcinoma; Piwi-like genes; Clear cell renal cell carcinoma; Quantitative RT-PCR; Age; Normal renal tissue; Tumorigenesis;
Mitochondrial NADP+-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells
Keywords: تومورزایی; Antioxidant enzyme; Melanoma; Tumorigenesis; Redox status; Angiogenesis;
β-Carotene inhibits neuroblastoma tumorigenesis by regulating cell differentiation and cancer cell stemness
Keywords: تومورزایی; β-Carotene; Neuroblastoma; Tumorigenesis; Differentiation; Cancer stem cells;
Distinct expression pattern of miRNAs in Marek's disease virus infected-chicken splenic tumors and non-tumorous spleen tissues
Keywords: تومورزایی; Marek's disease; MicroRNA; Tumorigenesis; Functional analysis
Human positive coactivator 4 (PC4) is involved in the progression and prognosis of astrocytoma
Keywords: تومورزایی; Human transcriptional coactivator 4; Astrocytoma; Clinicopathology; Tumorigenesis; Tumor progression; Survival;
Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy
Keywords: تومورزایی; Mps1; Overexpression; Spindle assembly checkpoint; Tumorigenesis; Aneuploidy;
High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene
Keywords: تومورزایی; Long non-coding RNA; H19; Bcr-Abl; Tumorigenesis; c-Myc;
TRAF6 is upregulated in colon cancer and promotes proliferation of colon cancer cells
Keywords: تومورزایی; TRAF6; Colon cancer; Cell proliferation; Tumorigenesis;
Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases
Keywords: تومورزایی; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Gαs; α-subunit of the stimulatory guanine nucleotide-binding protein; ARH; ADP-ribosyl-acceptor hydrolase; AIF; apoptosis-inducing factor; mito-PARP1cd; catalytic domain of PARP1 with a mitochondrial t
Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells
Keywords: تومورزایی; Promoter; Long non-coding RNA; Alfa-fetoprotein; Tumorigenesis; CREB;
RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress
Keywords: تومورزایی; RRM1; Centrosome integrity; Replication fork stalling; DNA damage; Tumor suppressor; Tumorigenesis;
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog
Keywords: تومورزایی; SERCA2; Colorectal cancer; Differentiation; Proliferation; Tumorigenesis
Silencing Met receptor tyrosine kinase signaling decreased oral tumor growth and increased survival of nude mice
Keywords: تومورزایی; MET; HGF receptor; Head and neck squamous cell carcinoma; Oral cancer; Tumorigenesis
A genetic program theory of aging using an RNA population model
Keywords: تومورزایی; Aging model; Repetitive sequences; Non-coding DNA and RNA; Aging; Differentiation; Tumorigenesis;
Suppression of tumorigenesis in mitochondrial NADP+-dependent isocitrate dehydrogenase knock-out mice
Keywords: تومورزایی; Antioxidant enzyme; Knockout mice; Tumorigenesis; Redox status; Host microenvironment;
Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells
Keywords: تومورزایی; Phosphatase 2A; PPP2R5E; miR-23a; Gastric cancer; Tumorigenesis; Apoptosis;
Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila
Keywords: تومورزایی; Tissue growth regulation; Cell–cell interaction; Tumorigenesis; Rab5; Drosophila