کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10903909 | 1086539 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications](/preview/png/10903909.png)
چکیده انگلیسی
MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 334, Issue 1, 15 May 2015, Pages 173-182
Journal: Experimental Cell Research - Volume 334, Issue 1, 15 May 2015, Pages 173-182
نویسندگان
Ying-fei Lu, Li Zhang, Mary Miu Yee Waye, Wei-ming Fu, Jin-fang Zhang,