دانلود مقالات ISI درباره Αsyn + ترجمه فارسی

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Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils

Keywords: AraC; cytosine arabinoside; αSyn; α-synuclein; BSA; bovine serum albumin; Con; control; CQ; chloroquine; DIV; days in vitro; DMSO; dimethyl sulfoxide; E. coli; Escherichia coli; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

مکانیسم های پریون و اهداف بالقوه درمانی در اختلالات نوروژنیک

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; DLB; dementia with Lewy bodies; MSA; multiple system atrophy; ALS; amyotrophic lateral sclerosis; αSyn; α-synuclein; TDP-43; TAR DNA binding protein of 43 kDa; FTLD; frontotemporal lobar degeneration; P

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

استرس بررسی کننده و بیماری پارکینسون: ورودی های آسیب شناختی که به مسیر ترشحی هم می آیند

ReviewER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway

Keywords: PD; Parkinson's disease; SNpc; substantia nigra pars compacta; LB; Lewy bodies; αSyn; αSynuclein; ER; endoplasmic reticulum; ERAD; ER-Associated Degradation; PINK1; PTEN-induced putative kinase 1; ATP13A2; lysosomal P-type transport ATPase; LRRK2; leuci

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

دژنراسیون وابسته به نورون های دوپامینرژیک منطقه قاعده شکمی در مدل لاکتاسیستین موش صحرایی موش صحرایی پارکینسونی و محافظت از عصبۀ آنها توسط والپروات

Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate

Keywords: PD; Parkinson's disease; SNpc; Substantia Nigra pars compacta; αSyn; α-synuclein; VTA; ventral tegmental area; UPS; ubiquitin proteasome systems; HAT; histone acetyltransferase; HDAC; histone deacetylase; HDACI; histone deacetylase inhibitor; TH; tyro

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

قطعات آنتی بادی تک سلولی شترید: استفاده و چشم انداز برای بررسی پروتئین غلط و تجمع پروتئین و درمان بیماری های مرتبط با این پدیده

Camelid single-domain antibody fragments: Uses and prospects to investigate protein misfolding and aggregation, and to treat diseases associated with these phenomena

Keywords: Variable domain of heavy-chain antibody; Inhibition of protein misfolding and aggregation; Protein misfolding diseases; Amyloidoses; VHH; Nanobody; Ab; antibody; Aβ; amyloid β-peptide; AD; Alzheimer's disease; ANS; anilino naphthalene-sulfonic acid; AP;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

Electrostatic and hydrophobic interactions of lipid-associated α-synuclein: The role of a water-limited interfaces in amyloid fibrillation

Keywords: αSyn; α‑synuclein; IDP; intrinsically disordered protein; LBs; Lewy bodies; LNs; Lewy neurites; ER; endoplasmic reticulum; NAC; non-amyloid-β component; PC; phosphatidylcholine; PS; phosphatidylserine; PUFA; polyunsaturated fatty acid; εr; relative

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

A new model to study cell-to-cell transfer of αSynuclein in vivo

Keywords: Parkinson's disease; αSynuclein; Cell-to-cell transfer; Sub-cellular compartments; Endoplasmic reticulum; Dopaminergic neuron; αSyn; αSynuclein; αSyn-CGFP; αSynuclein fused to carboxy-terminal; AAV; adeno-associated virus; BiFC; Bi-molecular Fluoresc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

Keywords: AD; Alzheimer's disease; AFM; atomic force microscopy; APP; amyloid precursor protein; Aβ; amyloid-β peptide; DHA; dihydro ascorbic acid; EPR; electron paramagnetic resonance; FAD; familial Alzheimer's disease; hAβ, hIAPP; human peptides; IAPP; isl

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration

Keywords: α-synuclein; Inflammation; Neurodegeneration; Prionoid transmission; RNAseq; αSyn; α-synuclein; Ast; Astrocyte; CD11b; cluster of differentiation molecule 11b; CNS; Central Nervous System; DEG; differentially expressed genes; DHS; DNase Hypersensitivit

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Protective effects of hydroxytyrosol against α-synuclein toxicity on PC12 cells and fibril formation

Keywords: AD; Alzheimer's Disease; Aβ; amyloid-β peptide; BBB; Blood Brain Barrier; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; EFSA; European Food Safety Authority; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; NQO1;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Ferroptosis and cell death mechanisms in Parkinson's disease

Keywords: Alpha-synuclein; Cell death; Ferroptosis; Parkinson's disease; 6-OHDA; 6-hydroxydopamine; ACSL4; acyl-CoA synthetase long-chain family member 4; AIF; apoptosis-inducing factor; APP; amyloid precursor protein; αsyn; alpha-synuclein; CSF; cerebrospinal flu

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewNeuroglobin: From structure to function in health and disease

Keywords: Neuroglobin; Structure; Function; Signaling; Neuroprotection; Neurodegeneration; Cancer; αSyn; α-synuclein; Aβ; amyloid β; AD; Alzheimer's disease; Adgb; androglobin; AIF; apoptotic inducing factor; AMPK; AMP-activated protein kinase; APAF; apoptotic

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease

Keywords: αSyn; alpha-synuclein; ALP; autophagy/lysosomal degradation pathway; CSF; cerebral spinal fluid; ERK5; extracellular-signal-regulated kinase 5; IL; interleukin; KI; knock-in; KO; knockout; LPS; lipopolysaccharide; LRRK2; leucine rich repeat kinase 2; MHC

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2015 سفارش ترجمه

Solution conditions define morphological homogeneity of α-synuclein fibrils

Keywords: αSyn; α-synuclein; AFM; Atomic Force Microscopy; A140C αSyn; substitution mutant of αSyn with residue 140 mutated from alanine to cysteine; EDTA; ethylenediaminetetraacetic acid; TCEP; tris(2-carboxyethyl)phosphine hydrochloride; DTT; dithiothreitol;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

Keywords: Ab; antibody; AD; Alzheimer's disease; αSYN; α-synuclein; CTSD; cathepsin D; CI-MPR; cation-independent mannose 6-phosphate receptor; DMEM; Dulbecco's modified Eagle's medium; elav; embryonic lethal abnormal vision; FBS; fetal bovine serum; GMR; glass m

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Exploring the accessible conformations of N-terminal acetylated α-synuclein

Keywords: αsyn; α-synuclein; Ac-αsyn; acetylated α-synuclein; BOG; beta-octyl glucopyranoside; GST; glutathione S-transferase; CD; circular dichroism; CN-PAGE; clear native PAGE; ESI-MS; electrospray ionization-mass spectrometry; ESI-IMS-MS; electrospray ioni

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Can Parkinson's disease pathology be propagated from one neuron to another?

Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; αsyn; α-synuclein; RBD; REM sleep behavior disorder; NAC; non-amyloid component; GWAS; genome wide association studies; TNTs; tunneling nanotubes; PrP; prion protein; Aβ; amyloid beta; MTBR; microtubule

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Interaction between α-synuclein and tau in Parkinson's disease

Keywords: AD; Alzheimer's disease; Aβ; β-amyloid; DAT; dopamine transporter; GSK-3β; glycogen-synthase-kinase-3β; IFG; inferior frontal gyrus; LB; Lewy body; NFT; neurofibrillary tangle; PD; Parkinson's disease; PDD; Parkinson's disease with dementia; pGSK-3β;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه