کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10030575 | 1594058 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos](/preview/png/10030575.png)
چکیده انگلیسی
We conducted a randomized open trial of oral chloramphenicol (50Â mg/kg/day in four divided doses for 14 days) versus ofloxacin (15Â mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (PÂ <Â 0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 99, Issue 6, June 2005, Pages 451-458
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 99, Issue 6, June 2005, Pages 451-458
نویسندگان
Simmaly Phongmany, Rattanaphone Phetsouvanh, Siho Sisouphone, Chirapha Darasavath, Pankham Vongphachane, Oudayvone Rattanavong, Mayfong Mayxay, Andrew C. Ramsay, Stuart D. Blacksell, Chanpheng Thammavong, Bounkong Syhavong, Nicholas J. White,