Model of the TBP-TFIIB Complex from Plasmodium falciparum: Interface Analysis and Perspectives as a New Target for Antimalarial Design

Currently there are no antimalarial drugs targeted to stop the nuclear transcription process, a vital event for all replication stages of P. falciparum. Due to its absolute requirement in transcription initiation, we consider the pfTBP-pfTFIIB interface as a new potential target for novel antimalarial chemotypes.