ORIGINAL RESEARCH-BASIC SCIENCE: Superoxide Anion Production in the Rat Penis Impairs Erectile Function in Diabetes: Influence of In Vivo Extracellular Superoxide Dismutase Gene Therapy

These data demonstrate that in vivo adenoviral gene transfer of EC‐SOD can reduce corporal superoxide anion levels and raise cavernosal cGMP levels by increasing NO bioavailability thus restoring erectile function in the STZ‐diabetic rat.