Divalent cations influence colon cancer cell adhesion in a murine transplantable tumor model

Thus, the high Mg2+ in endogenous wound fluid may potentiate tumor cell adhesion. However, 10 μmol/L Ca2+ inhibits cancer cell adhesion to murine wounds and subsequent tumor development. Irrigating with dilute CaCl2 could decrease local tumor recurrence by inhibiting the adhesion of shed tumor cells.