کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10106956 1615014 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical characteristics of PD patients with LRRK2 G2385R and R1628P variants
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Clinical characteristics of PD patients with LRRK2 G2385R and R1628P variants
چکیده انگلیسی
LRRK2 is the most common genetic cause of PD. G2385R and R1628 P variants are the most common variants of LRRK2 in Chinese populations. Consensus on the clinical features of G2385R and R1628 P related PD has not been reached yet, although it had been widely studied. In our study, genotype analyses were conducted on 721 PD patients of Chinese origin. A total of 62 G2385R carriers, 32 R1628 P carriers and 623 idiopathic PD patients underwent the following clinical feature analysis. Motor symptoms, non-motor symptoms and co-morbidities were the targeted features to be analyzed. As a result, Neither the G2385R nor the R1628 P carriers showed significant clinical feature differences when compared to the idiopathic PD patients, so did the comparison between the G2385R and the R1628 P carriers. In conclusion, the clinical features of PD patients with LRRK2 G2385R or R1628 P variants were similar to those of idiopathic PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 685, 15 October 2018, Pages 185-189
نویسندگان
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