کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10140356 | 1646012 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative assessment of grammar in amyloid-negative logopenic aphasia
ترجمه فارسی عنوان
ارزیابی کمی گرامر در آلفای لوپنیک منفی آمیلوئید
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Logopenic primary progressive aphasia (lvPPA) typically results from underlying Alzheimer's disease, but subjects have been reported that do not show beta-amyloid (Aβ) deposition. These subjects do not differ on neurological and speech-language testing from Aβ-positive lvPPA, but they impressionistically show increased grammatical deficits. We performed a quantitative linguistic analysis of grammatical characteristics in Aβ-negative lvPPA compared to Aβ-positive lvPPA and agrammatic PPA, which is characterized by increased grammatical difficulties. Aβ-negative lvPPA used fewer function words and correct verbs but more syntactic and semantic errors compared to Aβ-positive lvPPA. These measures did not differ between Aβ-negative lvPPA and agPPA. Both lvPPA cohorts showed a higher mean length of utterance, more complex sentences, and fewer nouns than agPPA. Aβ-negative lvPPA subjects appear unique and share linguistic features with both agPPA and Aβ-positive lvPPA. Quantitative language analysis in lvPPA may be able to distinguish those with and without Aβ deposition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Language - Volume 186, November 2018, Pages 26-31
Journal: Brain and Language - Volume 186, November 2018, Pages 26-31
نویسندگان
Katerina A. Tetzloff, Jennifer L. Whitwell, Rene L. Utianski, Joseph R. Duffy, Heather M. Clark, Mary M. Machulda, Edythe A. Strand, Keith A. Josephs,