کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10141229 | 1646062 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation, characterization and in vitro evaluation of melatonin-loaded porous starch for enhanced bioavailability
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation, characterization and in vitro evaluation of melatonin-loaded porous starch for enhanced bioavailability Preparation, characterization and in vitro evaluation of melatonin-loaded porous starch for enhanced bioavailability](/preview/png/10141229.png)
چکیده انگلیسی
The present work aimed to apply porous starch (PS) as carrier to improve the oral bioavailability of poorly soluble drug melatonin (MLT). The drug loading and encapsulation efficiency of MLT-loaded porous starch (MPS) were optimized. The characteristics of MPS were analyzed using scanning electron microscopy, Brunauer-Emmett-Teller surface area, Fourier-transform infrared spectroscopy, x-ray diffraction, differential scanning calorimetry and thermo gravimetric analysis. Most MLT transformed into their amorphous form in the PS pores. MPS showed higher MLT solubility and cumulative release rate compared with raw MLT in SGF and SIF. MPS exhibited a higher inhibition to DCFH-DA-oxidized peroxyl radicals at a lower EC50 than that of the raw MLT. Furthermore, the plasma concentrations of MLT and MPS reached a Cmax of 134.26 and 291.77âng/mL at 15 and 20âmin, respectively. The AUC0-360min of the formulated MPS-treated group was approximately 2.34-fold higher than that of raw MLT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 202, 15 December 2018, Pages 125-133
Journal: Carbohydrate Polymers - Volume 202, 15 December 2018, Pages 125-133
نویسندگان
Yuanyuan Li, Xiuhua Zhao, Lingling Wang, Yanjie Liu, Weiwei Wu, Chen Zhong, Qian Zhang, Jianhang Yang,