کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10147988 | 1646511 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Growth of high-quality metastable crystal of acetaminophen using solution-mediated phase transformation at low supersaturation
ترجمه فارسی عنوان
رشد کریستال متاستاز با کیفیت بالا استامینوفن با استفاده از تبدیل فاز حل شده میانجی در اشباع بالا
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
چکیده انگلیسی
We improved the crystal quality of the metastable phase of a pharmaceutical compound acetaminophen (form II) using solution-mediated phase transformation (SMPT) combined with the control of supersaturation and crystal size. Form II crystals grew at low supersaturation via SMPT of the trihydrate at low temperature (10â¯Â°C). While crystal growth rate was low compared to the 20â¯Â°C condition, crystals had many defects such as solution inclusions or cracks at 20â¯Â°C, but few at 10â¯Â°C. The ratio of form II crystals with any defects was small (12%), about 1/3 that of the 20â¯Â°C condition. Since the concentration gradient on the crystal surface was relatively small at low bulk supersaturation, high-quality crystals grew uniformly. However, large crystals (>â¼0.8â¯mm) were still defective even at low supersaturation, because concentration gradient is large on large surfaces. Using a new seed-dipping process, obtained crystals were small and uniform in size (â¼0.4â¯mm), and the ratio of defective crystals was reduced to 6%. Powder X-ray diffraction analysis revealed that form II crystals were â¼6 times more temporally stable than in the 20â¯Â°C condition. We found that high-quality crystals of metastable phase with high temporal stability could be realized by low supersaturation and reduction of the crystal size via SMPT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 502, 15 November 2018, Pages 76-82
Journal: Journal of Crystal Growth - Volume 502, 15 November 2018, Pages 76-82
نویسندگان
Riki Fujimoto, Mihoko Maruyama, Yoichiro Mori, Shino Okada, Hiroaki Adachi, Hiroshi Y. Yoshikawa, Kazufumi Takano, Satoshi Murakami, Hiroyoshi Matsumura, Tsuyoshi Inoue, Masayuki Imanishi, Katsuo Tsukamoto, Masashi Yoshimura, Yusuke Mori,