کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10153049 | 1666193 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A photoelectrochemical sensor for highly sensitive detection of amyloid beta based on sensitization of Mn:CdSe to Bi2WO6/CdS
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
A high sensitivity photoelectrochemical (PEC) immunosensor for amyloid beta (Aβ) detection, which has great neurotoxic effect on the progression of Alzheimer's disease (AD), was presented based on the sensitization of Mn2+ doped CdSe (Mn:CdSe) to Bi2WO6/CdS electrode. Bi2WO6 was synthesized successfully with a unique flower-like amorphous structure, providing a merit to load functional CdS for obtaining an expected PEC response. Mn:CdSe was used to label Aβ for acquiring Mn:CdSe-Aβ bioconjugate and enhancing the detection sensitivity via the competitive immunoreaction of Mn:CdSe-Aβ and Aβ with antibody immobilized on Bi2WO6/CdS electrode. The doped of Mn2+ in CdSe nanoparticles could induce energy defect that impeded the recombination of photo-generated charges, and greatly enhanced PEC response for ultrasensitive detection of Aβ. The proposed immunosensor for Aβ showed a linear range of 0.2â¯pgâ¯mLâ1-50â¯ngâ¯mLâ1 with a detection limit of 0.068â¯pgâ¯mLâ1, also with good stability, high selectivity, and acceptable reproducibility. The sensitization of Mn:CdSe provided a new way for preparation of highly sensitive protein biosensors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 122, 30 December 2018, Pages 37-42
Journal: Biosensors and Bioelectronics - Volume 122, 30 December 2018, Pages 37-42
نویسندگان
Rui Xu, Dong Wei, Bin Du, Wei Cao, Dawei Fan, Yong Zhang, Qin wei, Huangxian Ju,