کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
866153 1470944 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New biorecognition molecules in biosensors for the detection of toxins
ترجمه فارسی عنوان
مولکول های جدید بازشناسی زیستی در حسگرهای زیستی برای تشخیص سموم
کلمات کلیدی
گیرنده های زیستی؛ طرح های جدید ؛ حسگرهای زیستی؛ مولکول های سم؛ توسعه آینده
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی

Biological and synthetic recognition elements are at the heart of the majority of modern bioreceptor assays. Traditionally, enzymes and antibodies have been integrated in the biosensor designs as a popular choice for the detection of toxin molecules. But since 1970s, alternative biological and synthetic binders have been emerged as a promising alternative to conventional biorecognition elements in detection systems for laboratory and field-based applications. Recent research has witnessed immense interest in the use of recombinant enzymatic methodologies and nanozymes to circumvent the drawbacks associated with natural enzymes. In the area of antibody production, technologies based on the modification of in vivo synthesized materials and in vitro approaches with development of “display “systems have been introduced in the recent years. Subsequently, molecularly-imprinted polymers and Peptide nucleic acid (PNAs) were developed as an attractive receptor with applications in the area of sample preparation and detection systems. In this article, we discuss all alternatives to conventional biomolecules employed in the detection of various toxin molecules We review recent developments in modified enzymes, nanozymes, nanobodies, aptamers, peptides, protein scaffolds and DNazymes. With the advent of nanostructures and new interface materials, these recognition elements will be major players in future biosensor development.

Biological and synthetic recognition elements are at the heart of the majority of modern bioreceptor assays. Traditionally, enzymes and antibodies have been integrated in the biosensor. But since 1970s, alternative biological and synthetic receptors have been emerged as a promising alternative to conventional biorecognition elements in detection systems for laboratory and field-based applications. This includes nanozymes, nanobodies, aptamers, peptides, protein scaffolds and Dnazymes Conventional monoclonal antibodies (mAbs); antibodies from camelid (hcAb) and sharks (IgNAR).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 87, 15 January 2017, Pages 285–298
نویسندگان
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