کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10153064 | 1666193 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An integrated portable system for single chip simultaneous measurement of multiple disease associated metabolites
ترجمه فارسی عنوان
یک سیستم قابل حمل یکپارچه برای اندازه گیری همزمان یک تراشه از متابولیت های مرتبط با چند بیماری
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Metabolites, the small molecules that underpin life, can act as indicators of the physiological state of the body when their abundance varies, offering routes to diagnosis of many diseases. The ability to assay for multiple metabolites simultaneously will underpin a new generation of precision diagnostic tools. Here, we report the development of a handheld device based on complementary metal oxide semiconductor (CMOS) technology with multiple isolated micro-well reaction zones and integrated optical sensing allowing simultaneous enzyme-based assays of multiple metabolites (choline, xanthine, sarcosine and cholesterol) associated with multiple diseases. These metabolites were measured in clinically relevant concentration range with minimum concentrations measured: 25â¯Î¼M for choline, 100â¯Î¼M for xanthine, 1.25â¯Î¼M for sarcosine and 50â¯Î¼M for cholesterol. Linking the device to an Android-based user interface allows for quantification of metabolites in serum and urine within 2â¯min of applying samples to the device. The quantitative performance of the device was validated by comparison to accredited tests for cholesterol and glucose.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 122, 30 December 2018, Pages 88-94
Journal: Biosensors and Bioelectronics - Volume 122, 30 December 2018, Pages 88-94
نویسندگان
Samadhan B. Patil, Dharmendra S. Dheeman, Mohammed A. Al-Rawhani, Srinivas Velugotla, Bence Nagy, Boon Chong Cheah, James P. Grant, Claudio Accarino, Michael P. Barrett, David R.S. Cumming,