کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10156844 1666435 2018 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solution plasma mediated formation of low molecular weight chitosan and its application as a biomaterial
ترجمه فارسی عنوان
شکل گیری پلاکت پلاسمایی از کیتوزان کم مولکولی و کاربرد آن به عنوان یک ماده بیولوژیکی است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Low molecular weight (LMW) chitosan has been a great attention in bio-molecular chemistry, medicine, and drug delivery system in particular. Depolymerization of high molecular weight (HMW) chitosan to LMW chitosan was achieved by solution plasma process (SPP) without affecting its chemical structures. Chitosan in solution was depolymerized by discharging plasma at 800 V with 35 kHz for various times (15-120 min). Gel permeation chromatography analysis revealed that molecular weight of chitosan decreased from 3.0 × 105 Da to 7.8 × 103 Da in 30 min plasma treatment, and further to 4.6 × 103 Da in 90 min. Dynamic light scattering and zeta potential studies confirmed formation of chitosan nano-aggregates. Interestingly, the LMW chitosan samples showed antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans with minimal inhibitory concentration of 80-1200 μg·mL−1. They also exhibited an excellent antioxidant activity (58-75%) and swelling ratio of 0.2-2.0 mg·mg−1. LMW chitosan was likely to have potential for sustainable usage as carrier molecules, biomaterials, and biomedical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 118, Part B, 15 October 2018, Pages 1511-1517
نویسندگان
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