Characterization and evaluation of smart releasing polysaccharide from yellow poinciana seed of Jharkhand

Polysaccharides with unique functional and drug release characteristics have received more and more attention in the field of drug delivery systems. In this study, characterization of polysaccharide (PPSP) from yellow poinciana seeds and its utility as pharmaceutical excipient was investigated. The molecular weight of isolated PPSP was found to be 1.33 × 102 kDa. The high swelling and water binding capacity, low moisture content and fat-binding capacity of isolated polysaccharide explore to use as an excipient for drug delivery. The micromeritic properties revealed its flow and compressibility properties rendering its use in tablet manufacturing. Zeta potential measurements revealed PPSP as non-ionic polysaccharide. TGA data reveals a thermally stable polysaccharide and SEM confirms the fibrous network-like structure. The monosaccharide analysis confirmed the presence of galactose (49.94%), glucose (22.69%), mannose (15.99%), rhamnose (2.36%), arabinose (5.74%) and fucose (3.30%). The XRD pattern and viscosity measurements confirm the semi-crystalline nature and shear thinning behavior of polysaccharide respectively. The drug release profile indicates that the polysaccharide can be used as a potential agent for the design of smart pH-sensitive drug delivery systems.