کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10157795 1666484 2018 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan
ترجمه فارسی عنوان
مرتب سازی آکسون سلول گانگلیونی در چیسم اپتیکی نیاز به دیستروگلیکان دارد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
In the developing visual system, retinal ganglion cell (RGC) axons project from the retina to several distal retinorecipient regions in the brain. Several molecules have been implicated in guiding RGC axons in vivo, but the role of extracellular matrix molecules in this process remains poorly understood. Dystroglycan is a laminin-binding transmembrane protein important for formation and maintenance of the extracellular matrix and basement membranes and has previously been implicated in axon guidance in the developing spinal cord. Using two genetic models of functional dystroglycan loss, we show that dystroglycan is necessary for correct sorting of contralateral and ipsilateral RGC axons at the optic chiasm. Mis-sorted axons still target retinorecipient brain regions and persist in adult mice, even after axon pruning is complete. Our results highlight the importance of the extracellular matrix for axon sorting at an intermediate choice point in the developing visual circuit.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 442, Issue 2, 15 October 2018, Pages 210-219
نویسندگان
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