کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10159158 | 37 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel silk-based artificial ligament and tricalcium phosphate/polyether ether ketone anchor for anterior cruciate ligament reconstruction - Safety and efficacy in a porcine model
ترجمه فارسی عنوان
یک رشته مصنوعی مبتنی بر ابریشم و لنگر سه کلاسیوم فسفات / پلی اتر کتون برای بازسازی رباط صلیبی قدامی - ایمنی و کارآیی در یک مدل گوشت خوک
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Loss of ligament graft tension in early postoperative stages following ACL reconstruction can come from a variety of factors, with slow graft integration to bone being widely viewed as a chief culprit. Toward an off-the-shelf ACL graft that can rapidly integrate to host tissue, we have developed a silk-based ACL graft combined with a TCP/PEEK anchor. In the present study we tested safety and efficacy of this concept in a porcine model, with postoperative assessments at 3 months (n = 10) and 6 months (n = 4). Biomechanical tests were performed after euthanization, with ultimate tensile strengths at 3 months of â¼370 N and â¼566 N at 6 months - comparable with autograft and allograft performance in this animal model. Comprehensive histological observations revealed that TCP substantially enhanced silk graft to bone attachment. Interdigitation of soft and hard tissues was observed, with regenerated fibrocartilage characterizing a transitional zone from silk graft to bone that was similar to native ligament bone attachments. We conclude that both initial stability and robust long-term biological attachment were consistently achieved using the tested construct, supporting a large potential for silk-TCP combinations in the repair of the torn ACL.72
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 10, Issue 8, August 2014, Pages 3696-3704
Journal: Acta Biomaterialia - Volume 10, Issue 8, August 2014, Pages 3696-3704
نویسندگان
Xiang Li, Jiankang He, Weiguo Bian, Zheng Li, Wenyou Zhang, Dichen Li, Jess G. Snedeker,