کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10159174 | 39 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of molecular weight of grafted hyaluronic acid on wear initiation
ترجمه فارسی عنوان
تأثیر وزن مولکولی اسید هیالورونیک پیوند شده بر شروع سایش
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Hyaluronic acid (HA) of different molecular weights (Mw) was grafted onto mica surfaces to study the effects of Mw on the conformation and wear protection properties of a grafted HA (gHA) layer in lubricin (LUB) and bovine synovial fluid (BSF) using a surface forces apparatus. The Mw of gHA had significant effects on the wear pressure (Pw), at which point the wear initiates. Increasing the gHA Mw from 51 to 2590 kDa increased Pw from 4 to 8 MPa in LUB and from 15 to 31 MPa in BSF. The 2590 kDa gHA in BSF had the best wear protection (Pw â¼Â 31 MPa), even though it exhibited the highest friction coefficient (μ â¼Â 0.35), indicating that a low μ does not necessarily result in good wear protection, as is often assumed. The normal force profile indicated that BSF confines the gHA structure, making it polymer brush-like, commonly considered as an excellent structure for boundary lubrication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 10, Issue 5, May 2014, Pages 1817-1823
Journal: Acta Biomaterialia - Volume 10, Issue 5, May 2014, Pages 1817-1823
نویسندگان
Dong Woog Lee, Xavier Banquy, Saurabh Das, Nicholas Cadirov, Gregory Jay, Jacob Israelachvili,