Self-assembled pH-responsive hyaluronic acid-g-poly(l-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin

Amphiphilic hyaluronic acid-poly(l-histidine) (HA-PHis) copolymer was designed for use as a tumor targeted and pH-sensitive nanocarrier for intracellular delivery of doxorubicin. After CD44 receptor-mediated cellular uptake, doxorubicin was released rapidly in an intracellular low pH environment.169