کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10159464 49 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model
ترجمه فارسی عنوان
بررسی آنتی بیوتیک نگهدارنده فضای متخلخل پلی اتیل متیل اکریلات متخلخل در یک مدل نقص بافت کامپوزیت آلوده
کلمات کلیدی
نگهدارنده فضا، بازسازی سر و صورت، تحویل آنتی بیوتیک، نقص آلوده، نقص بافت کامپوزیت،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
This study evaluated the in vitro and in vivo performance of antibiotic-releasing porous polymethylmethacrylate (PMMA)-based space maintainers comprising a gelatin hydrogel porogen and a poly(dl-lactic-co-glycolic acid) (PLGA) particulate carrier for antibiotic delivery. Colistin was released in vitro from either gelatin or PLGA microparticle loaded PMMA constructs, with gelatin-loaded constructs releasing colistin over approximately 7 days and PLGA microparticle-loaded constructs releasing colistin for up to 8 weeks. Three formulations with either burst release or extended release at different doses were tested in a rabbit mandibular defect inoculated with Acinetobacter baumannii (2 × 107 colony forming units ml−1). In addition, one material control that released antibiotic but was not inoculated with A. baumannii was tested. A. baumannii was not detectable in any animal after 12 weeks on culture of the defect, saliva, or blood. Defects with high dose extended release implants had greater soft tissue healing compared with defects with burst release implants, with 8 of 10 animals showing healed mucosae compared with 2 of 10 respectively. Extended release of locally delivered colistin via a PLGA microparticle carrier improved soft tissue healing compared with implants with burst release of colistin from a gelatin carrier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 9, Issue 11, November 2013, Pages 8832-8839
نویسندگان
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